HLA typing in patients with recurrent aphthous stomatitis

Recurrent aphthous stomatitis (RAS) is a common oral disorder that despite extensive"nresearches, the etiology of this phenomenon is still unknown. Because this phenomenon has been observed"nmore often in families than in individual cases, genetic influence has been investigated in most researches."nPurpose: The aim of the present study was to evaluate the association between Human Leukocyte Antigen"n(HLA) and aphthous stomatitis more precisely."nMaterials and Methods: in this study, 60 patients with RAS were examined for HLA-A and HLA- B types"nand 37 of them were examined for HLA- DR and HLA-DQ types. The results were compared through Fisher"ntest with those of 25 healthy control subjects, aged more than 30 years."nResults: A significant decrease in the frequency of some antigens such as HLA-DQW 3 and HLA-A 26 in"nsubjects with RAS was observed. Therefore, according to the results of this study, these antigens were"nconsidered as resistant antigens to recurrent aphthous stomatitis. In contrast, there was no significant increase"nin the frequency of any HLA antigens in the test group, compared to the control group. This finding is in"ncontrast with the multiple reports about Behcet's disease. (Because a high frequency of HLA-B 51 has been"nfound in Behcet's syndrome.)"nConclusion: According to the findings of this study, it is suggested that the pathogenicity of aphthous"nulcerations in Behcet's disease and recurrent aphthous stomatitis is not the same. However, further studies are"nnecessary to prove this theory

COMPARISON OF ANTIMICROBIAL SENSITIVITY TO OLDER AND NEWER QUINOLONES VERSUS PIPERACILLIN-TAZOBACTAM, CEFEPIME AND MEROPENEM IN FEBRILE PATIENTS WITH CANCER IN TWO REFERRAL PEDIATRIC CENTERS IN TEHRAN, IRAN

Infection in pediatric cancer patients has become a concerning problem due to increasing antimicrobial resistance. The goal of this study was to determine the antimicrobial resistance patterns of blood isolates from pediatric oncology patients in Iran to determine if quinolones are appropriate for empiric therapy. Methods Children with cancer who were admitted with or developed fever during admission to Aliasghar Children’s Hospital or Mahak Hospitals July 2009 through June 2011 were eligible for enrollment. Two blood cultures were obtained.  Antimicrobial sensitivity test was performed for ciprofloxacin, moxifloxacin, gatifloxacin, meropenem, cefepime, and piperacillin-tazobactam on isolates from children who were bacteremic. Results Blood cultures were positive for 39 episodes in 169 enrolled children but 9 episodes were excluded as blood cultures were thought to be contaminated,  yielding a bacteremia rate of 29/160 (18%). The mean age of children and the stage of malignancy did not differ between those with and without bacteremia. Meropenem was the most likely antibiotic to cover isolates (97%) with cefepime having the lowest coverage rate (21%). Quinolone coverage ranged from 63%  to 76%. Conclusion Quinolones are not suitable for use as empiric therapy in febrile pediatric oncology patients in Iran