Acquisition, Maintenance and Generalization of Script Training: A Comparison of Errorful and Error-Reducing Conditions

Relatively few studies have investigated errorless versus errorful learning in aphasia, and most have focused on the single word level. In a review of a series of anomia studies, Fillingham et al. (2003) found that rate of success was equivalent for errorless and errorful conditions; the number of therapies using errorful techniques outweighed those based on errorless learning; errorless approaches were likely to achieve positive immediate effects, but many of the errorless studies did not report long term effects and generalization; and there was a lack of studies reporting a direct comparison of errorful and errorless learning. More recent work has continued to support the findings that there is no essential difference between error-free and errorless learning approaches (Middleton & Schwartz, 2012). However, none have investigated and contrasted the errorless/errorful learning paradigm in the production of phrases and sentences. This pilot study directly measures and compare the acquisition, maintenance and generalization of script-training under both error-reducing and errorful conditions. We hypothesized that error-reducing training would improve acquisition of a trained script while errorful learning would improve maintenance of the trained script and generalization to untrained scripts

A Chiral Spin Theory in the Framework of an Invariant Evolution Parameter Formalism

We present a formulation for the construction of first order equations which describe particles with spin, in the context of a manifestly covariant relativistic theory governed by an invariant evolution parameter; one obtains a consistent quantized formalism dealing with off-shell particles with spin. Our basic requirement is that the second order equation in the theory is of the Schr\"{o}dinger-Stueckelberg type, which exhibits features of both the Klein-Gordon and Schr\"{o}dinger equations. This requirement restricts the structure of the first order equation, in particular, to a chiral form. One thus obtains, in a natural way, a theory of chiral form for massive particles, which may contain both left and right chiralities, or just one of them. We observe that by iterating the first order system, we are able to obtain second order forms containing the transverse and longitudinal momentum relative to a time-like vector $t_{\mu}t^{\mu}=-1$ used to maintain covariance of the theory. This time-like vector coincides with the one used by Horwitz, Piron, and Reuse to obtain an invariant positive definite space-time scalar product, which permits the construction of an induced representation for states of a particle with spin. We discuss the currents and continuity equations, and show that these equations of motion and their currents are closely related to the spin and convection parts of the Gordon decomposition of the Dirac current. The transverse and longitudinal aspects of the particle are complementary, and can be treated in a unified manner using a tensor product Hilbert space. Introducing the electromagnetic field we find an equation which gives rise to the correct gyromagnetic ratio, and is fully Hermitian under the proposed scalar product. Finally, we show that the original structure of Dirac'sComment: Latex, 61 pages. Minor revisions. To be published in J. Math. Phy

Insecticide resistance and the future of malaria control in Zambia.

BACKGROUND: In line with the Global trend to improve malaria control efforts a major campaign of insecticide treated net distribution was initiated in 1999 and indoor residual spraying with DDT or pyrethroids was reintroduced in 2000 in Zambia. In 2006, these efforts were strengthened by the President's Malaria Initiative. This manuscript reports on the monitoring and evaluation of these activities and the potential impact of emerging insecticide resistance on disease transmission. METHODS: Mosquitoes were captured daily through a series of 108 window exit traps located at 18 sentinel sites. Specimens were identified to species and analyzed for sporozoites. Adult Anopheles mosquitoes were collected resting indoors and larva collected in breeding sites were reared to F1 and F0 generations in the lab and tested for insecticide resistance following the standard WHO susceptibility assay protocol. Annual cross sectional household parasite surveys were carried out to monitor the impact of the control programme on prevalence of Plasmodium falciparum in children aged 1 to 14 years. RESULTS: A total of 619 Anopheles gambiae s.l. and 228 Anopheles funestus s.l. were captured from window exit traps throughout the period, of which 203 were An. gambiae malaria vectors and 14 An. funestus s.s.. In 2010 resistance to DDT and the pyrethroids deltamethrin, lambda-cyhalothrin and permethrin was detected in both An. gambiae s.s. and An. funestus s.s.. No sporozoites were detected in either species. Prevalence of P. falciparum in the sentinel sites remained below 10% throughout the study period. CONCLUSION: Both An. gambiae s.s. and An. funestus s.s. were controlled effectively with the ITN and IRS programme in Zambia, maintaining a reduced disease transmission and burden. However, the discovery of DDT and pyrethroid resistance in the country threatens the sustainability of the vector control programme

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

Macromolecular modeling and design are increasingly useful in basic research, biotechnology, and teaching. However, the absence of a user-friendly modeling framework that provides access to a wide range of modeling capabilities is hampering the wider adoption of computational methods by non-experts. RosettaScripts is an XML-like language for specifying modeling tasks in the Rosetta framework. RosettaScripts provides access to protocol-level functionalities, such as rigid-body docking and sequence redesign, and allows fast testing and deployment of complex protocols without need for modifying or recompiling the underlying C++ code. We illustrate these capabilities with RosettaScripts protocols for the stabilization of proteins, the generation of computationally constrained libraries for experimental selection of higher-affinity binding proteins, loop remodeling, small-molecule ligand docking, design of ligand-binding proteins, and specificity redesign in DNA-binding proteins

Effects of price advertisements on perceived quality and purchase intentions

Within a communication framework, Adaptation Level Theory could help explain the cognitive process that consumers use to develop perceived-quality. The theory provided the framework for an advertising experiment that examined the effects of established brand prices in a rival advertisement, new brand prices and source credibility on perceived-quality of the new brand. The participants in the experiment were 120 college juniors and seniors. Results suggest that when the credibility of the source communicating the new brand price was high, established brand prices have an effect on perceived quality of the new brand. Conversely, when the source communicating the new brand price is low, established brand prices have little impact on perceived-quality of the new brand. These results occured even when the price of the new brand had no effect on perceived-quality. Results also suggest an interaction from the new brand price, the established brand price, and source credibility on purchase intentions toward the new brand

Comparative Advertising Effectiveness: The Role of Involvement and Source Credibility

Previous research on the persuasive impact of comparative advertising has produced inconsistent results. Consequently, researchers have suggested lack of credibility and the need for higher involvement as two problems which might impede the persuasive impact of comparative advertising. However, virtually no empirical evidence comparing the effects of comparative advertising to non-comparative advertising when different levels of involvement are activated exists. In addition, little research has examined whether source credibility enhances the persuasive impact of comparative advertising. Attribution theory provided the framework for the experiment reported in this paper. Experimental results suggest that when higher involvement is activated and a source of higher credibility is included in the advertisements, comparative advertising for a new brand has a more positive effect on purchase intentions than non-comparative advertising