51 research outputs found
Universality of Performance Indicators based on Citation and Reference Counts
We find evidence for the universality of two relative bibliometric indicators
of the quality of individual scientific publications taken from different data
sets. One of these is a new index that considers both citation and reference
counts. We demonstrate this universality for relatively well cited publications
from a single institute, grouped by year of publication and by faculty or by
department. We show similar behaviour in publications submitted to the arXiv
e-print archive, grouped by year of submission and by sub-archive. We also find
that for reasonably well cited papers this distribution is well fitted by a
lognormal with a variance of around 1.3 which is consistent with the results of
Radicchi, Fortunato, and Castellano (2008). Our work demonstrates that
comparisons can be made between publications from different disciplines and
publication dates, regardless of their citation count and without expensive
access to the whole world-wide citation graph. Further, it shows that averages
of the logarithm of such relative bibliometric indices deal with the issue of
long tails and avoid the need for statistics based on lengthy ranking
procedures.Comment: 15 pages, 14 figures, 11 pages of supplementary material. Submitted
to Scientometric
Current and prospective pharmacological targets in relation to antimigraine action
Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon
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