Results of unicompartmental osteoarthritis knee treated with high tibial osteotomy: a case series

High tibial osteotomy (HTO) being a re-emerged common procedure in orthopaedic practice now, which is safe and relatively simple and cost-effective technique requiring careful selection of subjects and precision of technique. Background: In isolated medial unicompartmental osteoarthritis (OA) of knee, in a physiologically young and high demanding individual, where preservation of knee is required, unicompartmental knee arthroplasty and total knee arthroplasty are not considered as treatment options. HTO is an excellent treatment option where the requirement of technical skills and infrastructure are less and high-volume low-cost surgeries can be performed with minimum instrumentation. 20 selected patients with unicompartmental OA of knee who attended the OPD of orthopaedics, Jorhat Medical College and Hospital were the subjects of this study, during the period of study from June 2020 to May 2021. In our study, average age was 55.9 years; higher incidence among females; higher incidence of OA in left knee; 80% of cases presented at Kellgren and Lawrence grade 2 and 3; most of the cases were having BMI within normal range and varus deformity of knee; plate and screw fixation after HTO provides more rigid fixation than staples alone. In this study, we got 60% good and 30% fair results after 6 months to 1 year of follow-up. Successful HTO is a very effective alternative low-cost surgery that makes it possible to delay or avoid knee arthroplasty in well selected patients

Safety Surveillance of Covid 19 vaccine in tertiary care hospital among target population - an observational study

Vaccines are a critical new tool in the battle against COVID-19. Development of safe and effective vaccines are necessary to combat the pandemic. The aim of the study is to provide public awareness to improve vaccination rate and prevent vaccination hesitancy by studying the knowledge, attitude and perception about COVID-19 vaccines, the occurrence of side effects after the administration of COVID-19 vaccine and its management. The participants who fulfilled the inclusion criteria were provided the previously structured and approved data collection form. The knowledge, attitude and perception towards COVID-19 vaccination was then determined by allocating a score for each response. The collected data was statistically interpreted using SPSS software and R software. The incidence of side effects following administration of 2 doses of COVID-19 vaccine and its management was analyzed. The knowledge regarding COVID-19 vaccinations was low among more than half of the total study population. Female gender showed a higher knowledge score compared to males. Nearly half of the study population (42.5%) was found to have a high attitude score. Age as a variable was found to be of significant association with attitude. It was concluded from our study that the majority of the participants were aware about the COVID-19 vaccines available in India. This study also points out that a majority of the participants experienced fear and hesitancy prior to getting vaccinated. Only a minority of the respondents were of the belief that vaccination would prevent the spread of COVID -19 infection

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Not AvailableA sensitive and accurate LC with tandem MS (MS/MS)-based method was developed and validated for the analysis of the herbicide glyphosate, its metabolite aminomethylphosphonic acid (AMPA), and glufosinate after derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) in various plant matrixes. The method also covers direct analysis of the glufosinate metabolites 3-methylphosphinicopropionic acid (3-MPPA) and N-acetyl-glufosinate (NAG). The homogenized samples were extracted with 0.1% formic acid in water–dichloromethane (50 + 50). The aqueous layer was derivatized with FMOC-Cl, cleaned through an HLB SPE cartridge, and determined by LC-MS/MS. The sample size, extraction solvent, sample-to-solvent ratio, derivatization conditions,and cleanup procedure were thoroughly optimized, the LOQs of glyphosate, glufosinate, and AMPA were 0.5 ng/g in grape, corn (leaf and seed), and cotton (leaf, seed, and oil) and 2 ng/g in soybean and tea. The LOQs of NAGand 3-MPPA were 50 ng/g in all the test matrixes, except tea and soybean, for which the LOQ was 100 ng/g. Inall cases, average recoveries were >80%. The method successfully performed the estimation of glyphosate in incurred corn and cotton leaf samples collected from supervised field trials.Not Availabl