Evidence for long-range glycosyl transfer reactions in the gas phase

AbstractA long-range glycosyl transfer reaction was observed in the collision-induced dissociation Fourier transform (CID FT) mass spectra of benzylamine-labeled and 9-aminofluorene-labeled lacto-N-fucopentaose I (LNFP I) and lacto-N-difucohexaose I (LNDFH I). The transfer reaction was observed for the protonated molecules but not for the sodiated molecules. The long-range glycosyl transfer reaction involved preferentially one of the two L-fucose units in labeled LNDFH I. CID experiments with labeled LNFP I and labeled LNFP II determined the fucose with the greatest propensity for migration. Further experiments were performed to determine the final destination of the migrating fucose. Molecular modeling supported the experiments and reaction mechanisms are proposed

IDRC president's address, June 19, 1992

Some text in FrenchIDRC president Keith A. Bezanson shares excitement over Prime Minister Brian Mulroney's endorsement of IDRC at the Rio Summit (the Prime Minister's speech appears at the end of the video); IDRC governors Flora MacDonald and Janet Wardlaw both speak briefl