Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction

AbstractOBJECTIVESThe purpose of this study was to evaluate the prevalence and diagnostic utility of cardiac troponin I to identify patients with right ventricular (RV) dysfunction in pulmonary embolism.BACKGROUNDRight ventricular overload resulting from elevated pulmonary resistance is a common finding in major pulmonary embolism. However, biochemical markers to assess the degree of RV dysfunction have not been evaluated so far.METHODSIn this prospective, double-blind study we included 36 study patients diagnosed as having acute pulmonary embolism.RESULTSAmong the whole study population, 14 patients (39%) had positive troponin I tests. Ten of 16 patients (62.5%) with RV dilatation had increased serum troponin I levels, while only 4 of 14 patients (28.6%) with elevated troponin I values had a normal RV diameter as assessed by echocardiography, indicating that positive troponin I tests were significantly associated with RV dilatation (p = 0.009). Patients with positive troponin I tests had significantly more segmental defects in ventilation/perfusion lung scans than patients with normal serum troponin I (p = 0.0002).CONCLUSIONSOur data demonstrate that more than one-third of patients clinically diagnosed as having pulmonary embolism presented with elevated serum troponin I concentrations. Troponin I tests helped to identify patients with RV dilatation who had significantly more segmental defects in lung scans. Thus, troponin I assays are useful to detect minor myocardial damage in pulmonary embolism

Complications and clinical outcome of hepatic artery embolisation in patients with hereditary haemorrhagic telangiectasia

BACKGROUND: Hepatic artery embolisation (HAE) in patients with hereditary haemorrhagic telangiectasia (HHT) is controversial because of the associated complications and unproven long-term benefit. We present our results in 20 such patients over a time span of 17 years. METHODS: Staged HAE was performed using polyvinyl alcohol (PVA) particles and coils. Complications, clinical symptoms and cardiac output were assessed before and after therapy as well as at the end of follow-up (median 92 months, range 26–208 months). RESULTS: Two patients died within 30 days following HAE (10 %). Four further deaths resulted from causes unrelated to HAE. Ischaemic cholangitis, cholecystitis and focal hepatic necrosis with biliary sepsis necessitated re-intervention in four patients. In all but one patient, clinical symptoms resolved with mean cardiac output falling from 11.84 ± 3.22 l/min pre-treatment to 8.13 ± 2.67 l/min at the end of follow-up (P < 0.001). One patient required liver transplantation for de novo symptoms of portal hypertension 4 years after primary symptoms had been cured by HAE. CONCLUSION: The 30-day mortality of HAE in patients with HHT is 10 %. The rate of complications requiring re-intervention is 20 %. Clinical response at long-term follow-up is satisfactory. KEY POINTS: • Hepatic artery embolisation (HAE) in hereditary haemorrhagic telangiectasia (HHT) provides long-term benefit. • Mortalities of HAE and liver transplantation in HHT patients are comparable. • In HHT, complications of HAE are lower than those of liver transplantation. • Complications of HAE can be further reduced by refinement of technique. • Complications include ischaemic cholangitis, hepatic necrosis, biliary sepsis and death

Effect of glyphosate on lipoxygenase of cowpea seed

Foi obtida, com solução de CaCl2 a 0,68 mM e pH 7,5, a atividade máxima de lipoxigenase em sementes de caupi (Vigna unguiculata (L.) Walp). Foram analisadas sementes durante a germinação, e observou-se que a atividade específica de lipoxigenase diminuiu durante o processo. Sementes de plantas tratadas com o herbicida glifosato (N - (fosfonometil) glicina) como dessecante mostraram significante aumento da atividade específica de lipoxigenase. Isto pode ser resultado do efeito do herbicida nas plantas. Tal conclusão é baseada no fato de que a. a lipoxigenase, que teve sua atividade específica aumentada pelo glifosato, pode promover a formação do ácido 12-oxo-fitodienóico; b. este, por sua vez, é um possível precursor do ácido jasmônico, um regulador de crescimento que promove senescência em plantas, explicando-se, desta maneira, a ação do herbicida nelas. Pelo método utilizado, não foi encontrada a enzima em folhas ou outras partes verdes das plantas. The predominant cowpea seed lipoxygenase was optimally activated by calcium at 0.68 mM and at pH 7.5. Seeds were analyzed during germinaton and showed a decrease in lipoxygenase specific activity with time. Seeds from plants treated with the herbicide glyphosate (N - (phosphonomethyl) glycine) showed a significant increase in lipoxygenase content. This could have been a result of senescence, or the effects of the herbicide on those plants. Such a conclusion is basead on findings that a. lipoxygenase, the activity of which was enhanced by glyphosate, has been reported to promote formation of 12-oxo-phytodienoic acid, and b. 12-oxo-phytodienoic acid has been proposed to be a precursor of jasmonic acid, a growth regulator which promotes senescence of plants. With the assay technique utilized, no lipoxygenase was found in mature leaves.

Efeito de glifosato em lipoxigenase de semente de caupi (Vigna unguiculata (L.) Walp.).

A atividade máxima de lipoxigenase em sementes de caupi (Vigna unguiculata (L.) Walp.) foi obtida com cálcio a 0,68 mM e pH 7.5. Sementes foram analisadas durante a germinação e a atividade especifica de lipoxigenase diminuiu durante o processo. Sementes de plantas tratadas com o herbicida glifosato [N - (fosofonometil) glicina] como dessecante, mostraram significante aumento da atividade especifica de lipooxigenase. Isto pode ser resultado do efeito do herbicida nas plantas. Tal conclusao e baseada no fato de que lipoxigenase, que teve sua atividade especifica aumentada pelo glifosato, pode promover a formação do ácido 12-oxo-fitodienoico que por sua vez É um possível precursor do acido jasmônico, um regulador de crescimento que promove senescência em plantas, explicando desta maneira a ação do herbicida nas mesmas. Pelo método utilizado, não foi encontrada a enzima em folhas ou outras partes verdes das plantas

Five-loop renormalisation of QCD in covariant gauges

We present the complete set of vertex, wave function and charge renormalisation constants in QCD in a general simple gauge group and with the complete dependence on the covariant gauge parameter $\xi$ in the minimal subtraction scheme of conventional dimensional regularisation. Our results confirm all already known results, which were obtained in the Feynman gauge, and allow the extraction of other useful gauges such as the Landau gauge. We use these results to extract the Landau gauge five-loop anomalous dimensions of the composite operator $A^2$ as well as the Landau gauge scheme independent gluon, ghost and fermion propagators at five loops.Comment: 17 pages; FORM and Mathematica result files available with the source; corrected minor typos, added references, journal ref, 1 remark, 1 note and 1 additional result fil

AgBase: a functional genomics resource for agriculture

BACKGROUND: Many agricultural species and their pathogens have sequenced genomes and more are in progress. Agricultural species provide food, fiber, xenotransplant tissues, biopharmaceuticals and biomedical models. Moreover, many agricultural microorganisms are human zoonoses. However, systems biology from functional genomics data is hindered in agricultural species because agricultural genome sequences have relatively poor structural and functional annotation and agricultural research communities are smaller with limited funding compared to many model organism communities. DESCRIPTION: To facilitate systems biology in these traditionally agricultural species we have established "AgBase", a curated, web-accessible, public resource for structural and functional annotation of agricultural genomes. The AgBase database includes a suite of computational tools to use GO annotations. We use standardized nomenclature following the Human Genome Organization Gene Nomenclature guidelines and are currently functionally annotating chicken, cow and sheep gene products using the Gene Ontology (GO). The computational tools we have developed accept and batch process data derived from different public databases (with different accession codes), return all existing GO annotations, provide a list of products without GO annotation, identify potential orthologs, model functional genomics data using GO and assist proteomics analysis of ESTs and EST assemblies. Our journal database helps prevent redundant manual GO curation. We encourage and publicly acknowledge GO annotations from researchers and provide a service for researchers interested in GO and analysis of functional genomics data. CONCLUSION: The AgBase database is the first database dedicated to functional genomics and systems biology analysis for agriculturally important species and their pathogens. We use experimental data to improve structural annotation of genomes and to functionally characterize gene products. AgBase is also directly relevant for researchers in fields as diverse as agricultural production, cancer biology, biopharmaceuticals, human health and evolutionary biology. Moreover, the experimental methods and bioinformatics tools we provide are widely applicable to many other species including model organisms

Looking through the QCD conformal window with perturbation theory

We study the conformal window of QCD using perturbation theory, starting from the perturbative upper edge and going down as much as we can towards the strongly coupled regime. We do so by exploiting the available five-loop computation of the $overline{{m MS}}$ $eta$-function and employing Borel resummation techniques both for the ordinary perturbative series and for the Banks-Zaks conformal expansion. Large-$n_f$ results are also used. We argue that the perturbative series for the $overline{{m MS}}$ $eta$-function is most likely asymptotic and non-Borel resummable, yet Borel resummation techniques allow to improve on ordinary perturbation theory. We find substantial evidence that QCD with $n_f=12$ flavours flows in the IR to a conformal field theory. Though the evidence is weaker, we find indications that also $n_f=11$ might sit within the conformal window. We also compute the value of the mass anomalous dimension $gamma$ at the fixed point and compare it with the available lattice results. The conformal window might extend for lower values of $n_f$, but our methods break down for n_f<11, where we expect that non-perturbative effects become important. A similar analysis is performed in the Veneziano limit

Free will and mental disorder: Exploring the relationship

A link between mental disorder and freedom is clearly present in the introduction of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). It mentions “an important loss of freedom” as one of the possible defining features of mental disorder. Meanwhile, it remains unclear how “an important loss of freedom” should be understood. In order to get a clearer view on the relationship between mental disorder and (a loss of) freedom, in this article, I will explore the link between mental disorder and free will. I examine two domains in which a connection between mental disorder and free will is present: the philosophy of free will and forensic psychiatry. As it turns out, philosophers of free will frequently refer to mental disorders as conditions that compromise free will and reduce moral responsibility. In addition, in forensic psychiatry, the rationale for the assessment of criminal responsibility is often explained by referring to the fact that mental disorders can compromise free will. Yet, in both domains, it remains unclear in what way free will is compromised by mental disorders. Based on the philosophical debate, I discuss three senses of free will and explore their relevance to mental disorders. I conclude that in order to further clarify the relationship between free will and mental disorder, the accounts of people who have actually experienced the impact of a mental disorder should be included in future research