Quantum Noise and Fluctuations in Gravitation and Cosmology

We give a short update of our research program on nonequilibrium statistical field theory applied to quantum processes in the early universe and black holes, as well as the development of stochastic gravity theory as an extension of semiclassical gravity and an intermediary in the 'bottom-up' approach to quantum gravity.Comment: 16 pages Latex; small changes in a couple of footnote

A new non-perturbative approach to Quantum Brownian Motion

Starting from the Caldeira-Leggett (CL) model, we derive the equation describing the Quantum Brownian motion, which has been originally proposed by Dekker purely from phenomenological basis containing extra anomalous diffusion terms. Explicit analytical expressions for the temperature dependence of the diffusion constants are derived. At high temperatures, additional momentum diffusion terms are suppressed and classical Langivin equation can be recovered and at the same time positivity of the density matrix(DM) is satisfied. At low temperatures, the diffusion constants have a finite positive value, however, below a certain critical temperature, the Master Equation(ME) does not satisfy the positivity condition as proposed by Dekker.Comment: 5 page

Free Energy of Twisted Semiflexible Polymers

We investigate the role of fluctuations in single molecule measurements of torque-link ($t-lk$) curves. For semiflexible polymers of finite persistence length (i.e. polymers with contour length $L$ comparable to the persistence length $L_P$), the torque versus link curve in the constant torque (isotorque) ensemble is distinct from the one in the constant link (isolink) ensemble. Thus, one encounters the conceptually interesting issue of a ``free energy of transition'' in switching ensembles while making torque-link measurements. We predict the dependence on the semiflexibility parameter $\beta = L/L_P$ of this extra contribution to the free energy which shows up as an area in the torque-link plane. This can be tested against future torque-link experiments with single biopolymers. We bring out the inequivalence of torque-link curves for a stiff polymer and present explicit analytical expressions for the {\it distinct} torque-link relations in the two ensembles and the free energy difference in switching ensembles in this context. The predictions of our work can be tested against single molecule experiments on torsionally constrained biopolymers.Comment: To appear in Physical Review

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Aging is associated with the accumulation of cellular damage over the course of a lifetime. This process is promoted in large part by reactive oxygen species (ROS) generated via cellular metabolic and respiratory pathways. Pharmacological, nonpharmacological, and genetic interventions have been used to target cellular and mitochondrial networks in an effort to decipher aging and age-related disorders. While ROS historically have been viewed as a detrimental byproduct of normal metabolism and associated with several pathologies, recent research has revealed a more complex and beneficial role of ROS in regulating metabolism, development, and lifespan. In this review, we summarize the recent advances in ROS research, focusing on both the beneficial and harmful roles of ROS, many of which are conserved across species from bacteria to humans, in various aspects of cellular physiology. These studies provide a new context for our understanding of the parts ROS play in health and disease. Moreover, we highlight the utility of bacterial models to elucidate the molecular pathways by which ROS mediate aging and aging-related diseases