41 research outputs found
Rapid and sensitive differentiation of anomers, linkage, and position isomers of disaccharides using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)
Full text linkSequencing of tri- and tetraantennary N-glycans containing sialic acid by negative mode ESI QTOF tandem MS
Full text linkFragmentation of negative ions from carbohydrates: Part 3. Fragmentation of hybrid and complex N-linked glycans
Full text linkCompeting fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans
Full text linkTandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides
Full text linkA mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria
No full textAlanine scanning mutagenesis of the charged amino acids of melanoma growth stimulating activity (MGSA) was used to identify specific residues that are involved in binding to the human erythrocyte Duffy antigen/chemokine receptor (DARC) and to the type B interleukin-8 receptor (IL-8RB) on neutrophils. Receptor binding and biological studies with the alanine scan mutants of MGSA demonstrate that MGSA binds to DARC and the IL-8RB through distinct binding regions. One of the MGSA mutants, E6A, binds to human erythrocytes and is able to inhibit malaria invasion as efficiently as wild type MGSA but has a severely reduced ability to bind to or signal through the IL-8RB. Mutant chemokines like E6A could prove to be useful therapeutically for the design of receptor blocking drugs that inhibit erythrocyte invasion by Plasmodium vivax malaria
Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum
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