Lipid biomarkers in Symbiodinium dinoflagellates : new indicators of thermal stress

Author Posting. © The Author(s), 2013. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Coral Reefs 32 (2013): 923-934, doi:10.1007/s00338-013-1076-3.Lipid content and fatty acid profiles of corals and their dinoflagellate endosymbionts are known to vary in response to high temperature stress. To better understand the heat stress response in these symbionts, we investigated cultures of Symbiodinium goreauii type C1 and Symbiodinium clade subtype D1 grown under a range of temperatures and durations. The predominant lipids produced by Symbiodinium are palmitic (C16) and stearic (C18) saturated fatty acids and their unsaturated analogs, docosahexaenoic (C22:6, n-3) polyunsaturated fatty acid (PUFA), and a variety of sterols. The relative amount of unsaturated acids within the C18 fatty acids in Symbiodinium tissue decreases in response to thermal stress. Prolonged exposure to high temperature also causes a decrease in abundance of fatty acids relative to sterols. These shifts in fatty acids and sterols are common to both types C1 and D1, but the apparent thermal threshold of lipid changes is lower for type C1. This work indicates that ratios among free fatty acids and sterols in Symbiodinium can be used as sensitive indicators of thermal stress. If the Symbdionium lipid stress response is unchanged in hospite, the algal heat stress biomarkers we have identified could be measured to detect thermal stress within the coral holobiont.. These results provide new insights into the potential role of lipids in the overall Symbiodinium thermal stress response.This research was supported by Award No. USA 00002 to K. Hughen made by King Abdullah University of Science and Technology (KAUST).2014-12-0

The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA

New quantitative data show that the Bicoid morphogen gradient is generated from a dynamic localized source and that protein gradient formation requires protein movement along the anterior-posterior axis

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis.

Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through alterations in the brain's excitation-inhibition balance that result in impaired behaviour and cognition. Although the factors that trigger these deficits are diverse, there is increasing evidence that they converge on a common pathological hub that involves NMDA receptor hypofunction and oxidative stress. These factors have been separately linked to schizophrenia pathogenesis, but evidence now suggests that they are mechanistically interdependent and contribute to a common schizophrenia-associated pathology

Os acromiale: evaluation of markers for identification on sagittal and coronal oblique MR images

 An os acromiale is a developmental abnormality of ossification involving the anterior acromion which may contribute to impingement and rotator cuff disease. When axial MR sections do not include the acromioclavicular joint, the diagnosis of this often subtle abnormality will rest on its recognition on oblique coronal and sagittal images where it mimics the acromioclavicular joint. The identification of this anomaly is important as it frequently alters the type of surgical procedure utilized in symptomatic patients. We evaluate several imaging features which may be used to diagnose an os acromiale in these cases.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42069/1/256-26-1-31_70260031.pd

Other fools and their doings, or, Life among the freedmen /

Menendez. Civil War novels,Mode of access: Internet