In-vivo magnetic resonance imaging of hyperpolarized silicon particles

Silicon-based micro and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in-vivo, as well as a flexible surface chemistry, which allows drug loading, functionalization and targeting. Here we report direct in-vivo imaging of hyperpolarized 29Si nuclei in silicon microparticles by MRI. Natural physical properties of silicon provide surface electronic states for dynamic nuclear polarization (DNP), extremely long depolarization times, insensitivity to the in-vivo environment or particle tumbling, and surfaces favorable for functionalization. Potential applications to gastrointestinal, intravascular, and tumor perfusion imaging at sub-picomolar concentrations are presented. These results demonstrate a new background-free imaging modality applicable to a range of inexpensive, readily available, and biocompatible Si particles.Comment: Supplemental Material include

Statistical variability in implant-free quantum-well MOSFETs with InGaAs and Ge: a comparative 3D simulation study

Introduction of high mobility channel materials including III-Vs and Ge into future CMOS generations offer the potential for enhanced transport properties compared to Si. The Implant Free Quantum Well (IFQW) architecture offers an attractive design to introduce these materials, providing excellent electrostatic integrity. Statistical variability introduced by the discreteness of charge and granularity of matter has become a key factor for current and future generations of MOSFETs and in this work numerical simulations are used to critically assess the statistical variability in IFQW transistors and compare results with equivalent conventional Si ‘bulk’ MOSFETs

Gravitation and Cosmology in Generalized (1+1)-dimensional dilaton gravity

The actions of the ``$R=T$'' and string-inspired theories of gravity in (1+1) dimensions are generalized into one single action which is characterized by two functions. We discuss differing interpretations of the matter stress-energy tensor, and show how two such different interpretations can yield two different sets of field equations from this action. The weak-field approximation, post-Newtonian expansion, hydrostatic equilibrium state of star and two-dimensional cosmology are studied separately by using the two sets of field equations. Some properties in the ``$R=T$'' and string-inspired theories are shown to be generic in the theory induced by the generalized action.Comment: 34 page

Exact Black Hole and Cosmological Solutions in a Two-Dimensional Dilaton-Spectator Theory of Gravity

Exact black hole and cosmological solutions are obtained for a special two-dimensional dilaton-spectator ($\phi-\psi$) theory of gravity. We show how in this context any desired spacetime behaviour can be determined by an appropriate choice of a dilaton potential function $V(\phi)$ and a ``coupling function'' $l(\phi)$ in the action. We illustrate several black hole solutions as examples. In particular, asymptotically flat double- and multiple- horizon black hole solutions are obtained. One solution bears an interesting resemblance to the $2D$ string-theoretic black hole and contains the same thermodynamic properties; another resembles the $4D$ Reissner-Nordstrom solution. We find two characteristic features of all the black hole solutions. First the coupling constants in $l(\phi)$ must be set equal to constants of integration (typically the mass). Second, the spectator field $\psi$ and its derivative $\psi^{'}$ both diverge at any event horizon. A test particle with ``spectator charge" ({\it i.e.} one coupled either to $\psi$ or $\psi^{'}$), will therefore encounter an infinite tidal force at the horizon or an ``infinite potential barrier'' located outside the horizon respectively. We also compute the Hawking temperature and entropy for our solutions. In $2D$ $FRW$ cosmology, two non-singular solutions which resemble two exact solutions in $4D$ string-motivated cosmology are obtained. In addition, we construct a singular model which describes the $4D$ standard non-inflationary big bang cosmology ($big-bang\rightarrow radiation\rightarrow dust$). Motivated by the similaritiesbetween $2D$ and $4D$ gravitational field equations in $FRW$ cosmology, we briefly discuss a special $4D$ dilaton-spectator action constructed from the bosonic part of the low energy heterotic string action andComment: 34 pgs. Plain Tex, revised version contains some clarifying comments concerning the relationship between the constants of integration and the coupling constants

Topological dilaton black holes

In four-dimensional spacetime, when the two-sphere of black hole event horizons is replaced by a two-dimensional hypersurface with zero or negative constant curvature, the black hole is referred to as a topological black hole. In this paper we present some exact topological black hole solutions in the Einstein-Maxwell-dilaton theory with a Liouville-type dilaton potential.Comment: 8 pages, Revtex, no figure

Rotating Dilaton Solutions in 2+1 Dimensions

We report a three parameter family of solutions for dilaton gravity in 2+1 dimensions with finite mass and finite angular momentum. These solutions are obtained by a compactification of vacuum solutions in 3+1 dimensions with cylindrical symmetry. One class of solutions corresponds to conical singularities and the other leads to curvature singularities.Comment: Accepted to be published in Gen. Rel. Grav., added reference

The Aphids (Homoptera: Aphididae) of British Columbia: 21. Further Additions

Seven species are added to the aphid fauna of British Columbia. Sixty-five of the 113 new aphid-host associations of plant species are newly recorded

The dynamics of liquid slugs forced by a syringe pump

Microfluidic processes for chemical synthesis have become popular in recent years. The small scale of the chemical reactions promise greater control over reaction conditions and more timely creation of products. The small scale of microfluidics poses its own set of problems, however. At the microscale, the dominant fluid forces are viscous resistance and surface tension. The effects of viscosity and scale reduce the Reynolds number and make mixing difficult. Much work has been done to control mixing at the microscale. This problem is concerned with a different microfluidic problem: delivering reactants to the site of reaction. A common setup is to attach syringes full of reactant to a reaction chamber by narrow hydrophobic tubing. Using a stepper motor, a controlled dose of liquid may be injected into the tube. The hydrophobosity causes the dose to curve outward on the sides, becoming a "slug" of reactant with air in front and behind. The syringe at the rear is then switched for one full of air, and air pressure is used to drive the slug to the reaction site. If too much pressure is applied, the slug will arrive with a significant back pressure that will be relieved through bubbling in the reaction site. This causes the formation of a foam and is highly undesirable. We present a simple model based on Boyle’s law for the motion of a slug through a tube. We then extend this model for trains of slugs separated by air bubbles. Last, we consider the case of a flooded reaction site, where the forward air bubble must be pushed through the flooding liquid. In conclusion, we have determined the dynamics of a single slug moving towards an empty reaction chamber giving the final equilibrium position of the slug. A phase-plane analysis then determined a condition on the size of the slug needed to ensure that it comes to rest without oscillating about the equilibrium position. The effect of a flooded reaction chamber was then considered. In this case it is impossible to avoid bubbling due to the design of the device. We found that it is possible, however, to reduce the bubbling by minimising the back pressure behind the slug. Finally, the dynamics of multiple slugs with or without a flooded reaction chamber has been investigated

Charged Black Cosmic String

Global U(1) strings with cylindrical symmetry are studied in anti-de Sitter spacetime. According as the magnitude of negative cosmological constant, they form regular global cosmic strings, extremal black cosmic strings and charged black cosmic strings, but no curvature singularity is involved. The relationship between the topological charge of a neutral global string and the black hole charge is clarified by duality transformation. Physical relevance as straight string is briefly discussed.Comment: ll pages, LaTe