2,012 research outputs found
Non-linear rheology of active particle suspensions: Insights from an analytical approach
We consider active suspensions in the isotropic phase subjected to a shear
flow. Using a set of extended hydrodynamic equations we derive a variety of
{\em analytical} expressions for rheological quantities such as shear viscosity
and normal stress differences. In agreement to full-blown numerical
calculations and experiments we find a shear thickening or -thinning behaviour
depending on whether the particles are contractile or extensile. Moreover, our
analytical approach predicts that the normal stress differences can change
their sign in contrast to passive suspensions.Comment: 11 pages, 10 figures, appear in PR
Targeting the innate immune system in pediatric and adult AML
While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult and pediatric AML has been relatively slow and limited. In addition to the need to identify suitable target antigens, a better understanding of the immunosuppressive tumor microenvironment is necessary for the design of novel immunotherapy approaches. To date, most immune characterization studies in AML have focused on T cells, while innate immune lineages such as monocytes, granulocytes and natural killer (NK) cells, received less attention. In solid cancers, studies have shown that innate immune cells, such as macrophages, myeloid-derived suppressor cells and neutrophils are highly plastic and may differentiate into immunosuppressive cells depending on signals received in their microenvironment, while NK cells appear to be functionally impaired. Hence, an in-depth characterization of the innate immune compartment in the TME is urgently needed to guide the development of immunotherapeutic interventions for AML. In this review, we summarize the current knowledge on the innate immune compartment in AML, and we discuss how targeting its components may enhance T cell-based- and other immunotherapeutic approaches.</p
Targeting the innate immune system in pediatric and adult AML
While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult and pediatric AML has been relatively slow and limited. In addition to the need to identify suitable target antigens, a better understanding of the immunosuppressive tumor microenvironment is necessary for the design of novel immunotherapy approaches. To date, most immune characterization studies in AML have focused on T cells, while innate immune lineages such as monocytes, granulocytes and natural killer (NK) cells, received less attention. In solid cancers, studies have shown that innate immune cells, such as macrophages, myeloid-derived suppressor cells and neutrophils are highly plastic and may differentiate into immunosuppressive cells depending on signals received in their microenvironment, while NK cells appear to be functionally impaired. Hence, an in-depth characterization of the innate immune compartment in the TME is urgently needed to guide the development of immunotherapeutic interventions for AML. In this review, we summarize the current knowledge on the innate immune compartment in AML, and we discuss how targeting its components may enhance T cell-based- and other immunotherapeutic approaches.</p
Structure and Strength of Dislocation Junctions: An Atomic Level Analysis
The quasicontinuum method is used to simulate three-dimensional
Lomer-Cottrell junctions both in the absence and in the presence of an applied
stress. The simulations show that this type of junction is destroyed by an
unzipping mechanism in which the dislocations that form the junction are
gradually pulled apart along the junction segment. The calculated critical
stress needed for breaking the junction is comparable to that predicted by line
tension models. The simulations also demonstrate a strong influence of the
initial dislocation line directions on the breaking mechanism, an effect that
is neglected in the macroscopic treatment of the hardening effect of junctions.Comment: 4 pages, 3 figure
Anti-de Sitter Supersymmetry
We give a pedagogical introduction to certain aspects of supersymmetric field
theories in anti-de Sitter space. Among them are the presence of masslike terms
in massless wave equations, irreducible unitary representations and the
phenomenon of multiplet shortening.Comment: Lectures presented by B. de Wit at the Winter School of Theoretical
Physics, Polanica, Poland, February 1999. 23 pp., LateX file, requires
packages latexsym, amsfonts, cl2emult.cl
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