Ultrahigh-pressure metamorphism and exhumation of garnet-bearing ultramafic rocks from the Lanterman Range (northern Victoria Land, Antarctica)

Northern Victoria Land is a key area for the Ross Orogen - a Palaeozoic foldbelt formed at the palaeo-Pacific margin of Gondwana. A narrow and discontinuous high- to ultrahigh-pressure (UHP) belt, consisting of mafic and ultramafic rocks (including garnet-bearing types) within a metasedimentary sequence of gneisses and quartzites, is exposed at the Lanterman Range (northern Victoria Land). Garnet-bearing ultramafic rocks evolved through at least six metamorphic stages. Stage 1 is defined by medium-grained garnet+olivine+low-Al orthopyroxene+clinopyroxene, whereas finer-grained garnet+olivine+orthopyroxene+clinopyroxene+amphibole constitutes the stage 2 assemblage. Stage 3 is defined by kelyphites of orthopyroxene+clinopyroxene+spinel±amphibole around garnet. Porphyroblasts of amphibole replacing garnet and clinopyroxene characterize stage 4. Retrograde stages 5 and 6 consist of tremolite+Mg-chlorite±serpentine±talc. A high-temperature (∼950°C), spinel-bearing protolith (stage 0), is identified on the basis of orthopyroxene+clinopyroxene+olivine+spinel+amphibole inclusions within stage 1 garnet. The P-T estimates for stage 1 are indicative of UHP conditions (3.2-3.3 GPa and 764-820°C), whereas stage 2 is constrained between 726-788°C and 2.6-2.9 GPa. S

Mortality on the Waiting List for Lung Transplantation in Patients with Idiopathic Pulmonary Fibrosis: A Single-Centre Experience

Purpose: Lung transplantation (LTX) is nowadays accepted as a treatment option for selected patients with end-stage pulmonary disease. Idiopathic pulmonary fibrosis (IPF) is characterized by the radiological and histologic appearance of usual interstitial pneumonia. It is associated with a poor prognosis, and LTX is considered an effective treatment to significantly modify the natural history of this disease. The aim of the present study was to analyse mortality during the waiting list in IPF patients at a single institution. Methods: A retrospective analysis on IPF patients (n = 90) referred to our Lung Transplant Program in the period 2001–2014 was performed focusing on patients’ characteristics and associated risk factors. Results: Diagnosis of IPF was associated with high mortality on the waiting list with respect to other diagnosis (p < 0.05). No differences in demographic, clinical, radiological data and time spent on the waiting list were observed between IPF patients who underwent to LTX or lost on the waiting list. Patients who died showed significant higher levels of pCO2 and needed higher flows of O2-therapy on effort (p < 0.05). Pulmonary function tests failed to predict mortality and no other medical conditions were associated with survival. Conclusions: Patients newly diagnosed with IPF, especially in small to medium lung transplant volume centres and in Countries where a long waiting list is expected, should be immediately referred to transplantation, delay results in increased mortality. Early identification of IPF patients with a rapid progressive phenotype is strongly needed