914 research outputs found
Reliable scientific service compositions
Abstract. Distributed service oriented architectures (SOAs) are increas-ingly used by users, who are insufficiently skilled in the art of distributed system programming. A good example are computational scientists who build large-scale distributed systems using service-oriented Grid comput-ing infrastructures. Computational scientists use these infrastructure to build scientific applications, which are composed from basic Web ser-vices into larger orchestrations using workflow languages, such as the Business Process Execution Language. For these users reliability of the infrastructure is of significant importance and that has to be provided in the presence of hardware or operational failures. The primitives avail-able to achieve such reliability currently leave much to be desired by users who do not necessarily have a strong education in distributed sys-tem construction. We characterise scientific service compositions and the environment they operate in by introducing the notion of global scien-tific BPEL workflows. We outline the threats to the reliability of such workflows and discuss the limited support that available specifications and mechanisms provide to achieve reliability. Furthermore, we propose a line of research to address the identified issues by investigating auto-nomic mechanisms that assist computational scientists in building, exe-cuting and maintaining reliable workflows.
OGSA first impressions: a case study re-engineering a scientific applicationwith the open grid services architecture
We present a case study of our experience re-engineeringa scientific application using the Open Grid Services Architecture(OGSA), a new specification for developing Gridapplications using web service technologies such as WSDLand SOAP. During the last decade, UCL?s Chemistry departmenthas developed a computational approach for predictingthe crystal structures of small molecules. However,each search involves running large iterations of computationallyexpensive calculations and currently takes a fewmonths to perform. Making use of early implementationsof the OGSA specification we have wrapped the Fortranbinaries into OGSI-compliant service interfaces to exposethe existing scientific application as a set of loosely coupledweb services. We show how the OGSA implementationfacilitates the distribution of such applications across alarge network, radically improving performance of the systemthrough parallel CPU capacity, coordinated resourcemanagement and automation of the computational process.We discuss the difficulties that we encountered turning Fortranexecutables into OGSA services and delivering a robust,scalable system. One unusual aspect of our approachis the way we transfer input and output data for the Fortrancodes. Instead of employing a file transfer service wetransform the XML encoded data in the SOAP message tonative file format, where possible using XSLT stylesheets.We also discuss a computational workflow service that enablesusers to distribute and manage parts of the computationalprocess across different clusters and administrativedomains. We examine how our experience re-engineeringthe polymorph prediction application led to this approachand to what extent our efforts have succeeded
Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment
Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal antibodies are making major contributions to this progress. As a consequence, the options for treatment of CLL are considerably more diverse now than a few years ago, and now include procedures that take into account age and risk. At the same time, it should be emphasized that many important questions regarding the treatment of CLL remain unresolved. It is anticipated that these questions will be answered over the coming few years by including patients in multicentre studies like those being carried out by the German CLL study group
Grid service orchestration using the Business Process Execution Language (BPEL)
Modern scientific applications often need to be distributed across grids. Increasingly
applications rely on services, such as job submission, data transfer or data
portal services. We refer to such services as grid services. While the invocation
of grid services could be hard coded in theory, scientific users want to orchestrate
service invocations more flexibly. In enterprise applications, the orchestration of
web services is achieved using emerging orchestration standards, most notably
the Business Process Execution Language (BPEL). We describe our experience
in orchestrating scientific workflows using BPEL. We have gained this experience
during an extensive case study that orchestrates grid services for the automation of
a polymorph prediction application
Prevalence of CD20 positive B-cells in peripheral blood of patients with lymphocytic lymphoma and correlation with the course of disease
Chronopharmacology of mitoxantrone (MX): Evodence for a circadian rhythm of its myelotoxicity from an animal model and a clinical pilot trial
High-dose chemotherapy with hematopoietic stem cell transplantation for patients with advanced multiple myeloma
Chronotherapy with 5-Fluorouracil (5-FU) and folinic acid (FA) in advanced colorectal carcinoma: Results of a chronopharmacologic phase I/II trial
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