Clinical profiles and trends in CD4+ counts to first-line antiretroviral therapy among HIV/AIDS patients in western part of Odisha state of India

Background: HIV infection is globally pandemic and about 36.7 million people living with HIV/ AIDS (PLHA) in 2016. At present CD4+ count is the gold standard of immunological marker of disease severity. Highly active antiretroviral therapy (HAART) is the first line of treatment to improve CD4 count. AIMS AND OBJECTIVES of study was to observe the clinical profiles and response in CD4+ counts to first-line HAART in PLHA and their adverse reactions.Methods: Total 153 PLHA with CD4+ counts <250/µl was consecutively taken in the study and detail clinical examinations, baseline CD4+ counts and body weights were noted. HAART was started in 26 (16.99%), 37 (24.18%), 78 (50.98%) and 12 (7.84%) cases in WHO clinical stages of I, II, III, and V respectively and CD4+ counts, body weight and any adverse drug reactions were noted at 15 days, 3, 6, 18 and 24 months intervals and data were collected and analyzed.Results: Out of 153 cases 89 were male and 64 were female. Mean age was 35.4±9.08 years for male and 30.2±5.75 years for female. Mean baseline CD4+ count was 202±75/µl and mean body weight was 47.44kg. Mean CD4+ count was increased to 314.22±166.53, 343±194.02, 378±221.30 and 299.6±146.55/µl at 6, 12, 18 and 24 months respectively. Commonest adverse drug reaction was headache and GIT side effects.Conclusions: HAART improves clinical and immunological parameter CD4+ count in PLHA, irrespective of their clinical stages. Headache and GIT manifestations are commonest adverse drug reactions

New Approach to Parton Shower MC's for Precision QCD Theory: HERWIRI1.0(31)

By implementing the new IR-improved Dokshitzer-Gribov-Lipatov-Altarelli-Parisi-Callan-Symanzik (DGLAP-CS) kernels recently developed by one of us in the HERWIG6.5 environment we generate a new MC, HERWIRI1.0(31), for hadron-hadron scattering at high energies. We use MC data to illustrate the comparison between the parton shower generated by the standard DGLAP-CS kernels and that generated by the new IR-improved DGLAP-CS kernels. The interface to MC@NLO, MC@NLO/HERWIRI, is illustrated. Comparisons with FNAL data and some discussion of possible implications for LHC phenomenology are also presented.Comment: 24 pages, 10 figures; published versio

Interplay of IR-Improved DGLAP-CS Theory and NLO Parton Shower MC Precision

We present the interplay between the new IR-improved DGLAP-CS theory and the precision of NLO parton shower/ME matched MC`s as it is realized by the new MC Herwiri1.031 in interface to MC@NLO. We discuss phenomenological implications using comparisons with recent LHC data on single heavy gauge boson production.Comment: 8 pages, 4 figures; presented by BFLW at ICHEP 201

A Deterministic Approach of Merging of Blocks in Transversal Design based Key Predistribution

Transversal Design is a well known combinatorial design that has been used in deterministic key predistribution scheme. Merging of blocks in a design sometimes helps to obtain a key predistribution scheme with better performance. A deterministic merging strategy to merge the blocks has been discussed. Also, a simple key establishment method for transversal design based key predistribution scheme has been discussed