SYNTHESIS, CHARACTERIZATION AND IN VITRO MICROBIAL EVALUATION OF REGIOISOMERS OF ALLYL PHENYL ETHERS DERIVED 1, 2, 4-TRIAZOLES

Objective: Synthesis and antimicrobial evaluation of regioisomers of allyl phenyl ethers derived 1, 2, 4-triazoles. Methods: A series of new 1,2,4-triazole derivatives of allyl phenyl ethers were synthesized by reacting a mixture of regio isomers 1-(3-bromo-2-methoxypropoxy)-arene and 1-(2-bromo-3-methoxypropoxy)-arene with 1,2,4-triazole in presence of K2CO3 and DMF at 80oC in good yields. Allyl phenyl ethers 1(a-f) were synthesized by refluxing the substituted phenols with allyl bromide in the presence of K2CO3 and acetone in excellent yields. The newly synthesized compounds were characterized by IR, 1HNMR, Mass spectral studies and elemental analysis. These compounds were also screened for their In-vitro antibacterial and antifungal activities. Results: Allyl phenyl ethers derived 1,2,4-triazol derivatives were synthesized in good yields. Conclusion: Preliminary results revealed that some of the synthesized compounds were showed promising antibacterial and antifungal activity