Prediction of protein submitochondria locations by hybridizing pseudo-amino acid composition with various physicochemical features of segmented sequence

BACKGROUND: Knowing the submitochondria localization of a mitochondria protein is an important step to understand its function. We develop a method which is based on an extended version of pseudo-amino acid composition to predict the protein localization within mitochondria. This work goes one step further than predicting protein subcellular location. We also try to predict the membrane protein type for mitochondrial inner membrane proteins. RESULTS: By using leave-one-out cross validation, the prediction accuracy is 85.5% for inner membrane, 94.5% for matrix and 51.2% for outer membrane. The overall prediction accuracy for submitochondria location prediction is 85.2%. For proteins predicted to localize at inner membrane, the accuracy is 94.6% for membrane protein type prediction. CONCLUSION: Our method is an effective method for predicting protein submitochondria location. But even with our method or the methods at subcellular level, the prediction of protein submitochondria location is still a challenging problem. The online service SubMito is now available at

Maximally Symmetric Minimal Unification Model SO(32) with Three Families in Ten Dimensional Space-time

Based on a maximally symmetric minimal unification hypothesis and a quantum charge-dimension correspondence principle, it is demonstrated that each family of quarks and leptons belongs to the Majorana-Weyl spinor representation of 14-dimensions that relate to quantum spin-isospin-color charges. Families of quarks and leptons attribute to a spinor structure of extra 6-dimensions that relate to quantum family charges. Of particular, it is shown that 10-dimensions relating to quantum spin-family charges form a motional 10-dimensional quantum space-time with a generalized Lorentz symmetry SO(1,9), and 10-dimensions relating to quantum isospin-color charges become a motionless 10-dimensional quantum intrinsic space. Its corresponding 32-component fermions in the spinor representation possess a maximal gauge symmetry SO(32). As a consequence, a maximally symmetric minimal unification model SO(32) containing three families in ten dimensional quantum space-time is naturally obtained by choosing a suitable Majorana-Weyl spinor structure into which quarks and leptons are directly embedded. Both resulting symmetry and dimensions coincide with the ones of type I string and heterotic string SO(32) in string theory.Comment: 17 pages, RevTex, published version with minor typos correcte

Commensurate Fluctuations in the Pseudogap and Incommensurate spin-Peierls Phases of TiOCl

X-ray scattering measurements on single crystals of TiOCl reveal the presence of commensurate dimerization peaks within both the incommensurate spin-Peierls phase and the so-called pseudogap phase above T_c2. This scattering is relatively narrow in Q-space indicating long correlation lengths exceeding ~ 100 A below T* ~ 130 K. It is also slightly shifted in Q relative to that of the commensurate long range ordered state at the lowest temperatures, and it coexists with the incommensurate Bragg peaks below T_c2. The integrated scattering over both commensurate and incommensurate positions evolves continuously with decreasing temperature for all temperatures below T* ~ 130 K.Comment: To appear in Physical Review B: Rapid Communications. 5 page

Anomalous Magnetic and Thermal Behavior in Some RMn2O5 Oxides

The RMn2O5 (R=Pr, Nd, Sm, and Eu) oxides showing magnetoelectric (ME) behavior have been prepared in polycrystalline form by a standard citrate route. The lattice parameters, obtained from the powder XRD analysis, follow the rare-earth contraction indicating the trivalent character of the R ions. Cusp-like anomalies in the magnetic susceptibility curve and sharp peaks in the specific heat were reported at the corresponding temperatures in RMn2O5 (R=Pr, Nd, Sm, and Eu) indicating the magnetic or electric ordering transitions.Comment: 2 pages, 1 table, 3 figures, will be published in the Proceedings of the 24th International Conference on Low Temperature Physic

Suppression of the commensurate spin-Peierls state in Sc-doped TiOCl

We have performed x-ray scattering measurements on single crystals of the doped spin-Peierls compound Ti(1-x)Sc(x)OCl (x = 0, 0.01, 0.03). These measurements reveal that the presence of non-magnetic dopants has a profound effect on the unconventional spin-Peierls behavior of this system, even at concentrations as low as 1%. Sc-doping suppresses commensurate fluctuations in the pseudogap and incommensurate spin-Peierls phases of TiOCl, and prevents the formation of a long-range ordered spin-Peierls state. Broad incommensurate scattering develops in the doped compounds near Tc2 ~ 93 K, and persists down to base temperature (~ 7 K) with no evidence of a lock-in transition. The width of the incommensurate dimerization peaks indicates short correlation lengths on the order of ~ 12 angstroms below Tc2. The intensity of the incommensurate scattering is significantly reduced at higher Sc concentrations, indicating that the size of the associated lattice displacement decreases rapidly as a function of doping.Comment: 7 pages, 5 figure

Anomalous electronic Raman scattering in Na_xCoO_2 H_2O

Raman scattering experiments on Na_{x}CoO_2 yH_2O single crystals show a broad electronic continuum with a pronounced peak around 100 cm-1 and a cutoff at approximately 560 cm-1over a wide range of doping levels. The electronic Raman spectra in superconducting and non-superconducting samples are similar at room temperature, but evolve in markedly different ways with decreasing temperature. For superconducting samples, the low-energy spectral weight is depleted upon cooling below T* sim 150K, indicating a opening of a pseudogap that is not present in non-superconducting materials. Weak additional phonon modes observed below T* suggest that the pseudogap is associated with charge ordering.Comment: 5 pages, 4 figures, for further information see www.peter-lemmens.d

Adipose stem cell coating of biomimetic β-TCP macrospheres by use of laboratory centrifuge

Biomimetic materials such as coral exoskeletons possess unique architectural structures with a uniform and interconnected porous network that can be beneficial as a scaffold material. In addition, these marine structures can be hydrothermally converted to calcium phosphates, while retaining the original structural properties. The ability of biomaterials to stimulate the local microenvironment is one of the main focuses in tissue engineering, and directly coating the scaffold with stem cells facilitates future potential applications in therapeutics and regenerative medicine. In this article we describe a new and simple method that uses a laboratory centrifuge to coat hydrothermally derived beta-tricalcium phosphate macrospheres from coral exoskeleton with stem cells. In this research the optimal seeding duration and speed were determined to be 1 min and 700 g. Scanning electron micrographs showed complete surface coverage by stem cells within 7 days of seeding. This study constitutes an important step toward achieving functional tissue-engineered implants by increasing our understanding of the influence of dynamic parameters on the efficiency and distribution of stem cell attachment to biomimetic materials and how stem cells interact with biomimetic materials. © Copyright 2013, Mary Ann Liebert, Inc. 2013

Towards experimental entanglement connection with atomic ensembles in the single excitation regime

We present a protocol for performing entanglement connection between pairs of atomic ensembles in the single excitation regime. Two pairs are prepared in an asynchronous fashion and then connected via a Bell measurement. The resulting state of the two remaining ensembles is mapped to photonic modes and a reduced density matrix is then reconstructed. Our observations confirm for the first time the creation of coherence between atomic systems that never interacted, a first step towards entanglement connection, a critical requirement for quantum networking and long distance quantum communications

The Need to Feed Homeostatic and Hedonic Control of Eating

AbstractFeeding provides substrate for energy metabolism, which is vital to the survival of every living animal and therefore is subject to intense regulation by brain homeostatic and hedonic systems. Over the last decade, our understanding of the circuits and molecules involved in this process has changed dramatically, in large part due to the availability of animal models with genetic lesions. In this review, we examine the role played in homeostatic regulation of feeding by systemic mediators such as leptin and ghrelin, which act on brain systems utilizing neuropeptide Y, agouti-related peptide, melanocortins, orexins, and melanin concentrating hormone, among other mediators. We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition