9 research outputs found
Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins
No full textNew Agents in Treatment of Hyperkalemia: an Opportunity to Optimize Use of RAAS Inhibitors for Blood Pressure Control and Organ Protection in Patients with Chronic Kidney Disease
No full textOsmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway
No full textMaladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis
No full textRXRs: collegial partners.
No full textRetinoid X Receptors (RXR) were initially identified as nuclear receptors binding with stereo-selectivity the vitamin A derivative 9-cis retinoic acid, although the relevance of this molecule as endogenous activator of RXRs is still elusive. Importantly, within the nuclear receptor superfamily, RXRs occupy a peculiar place, as they are obligatory partners for a number of other nuclear receptors, thus integrating the corresponding signaling pathways. In this chapter, we describe the structural features allowing RXR to form homo- and heterodimers, and the functional consequences of this unique ability. Furthermore, we discuss the importance of studying RXR activity at a genome-wide level in order to comprehensively address the biological implications of their action that is fundamental to understand to what extent RXRs could be exploited as new therapeutic targets
