Free dense subgroups of holomorphic automorphisms

We show the existence of free dense subgroups, generated by 2 elements, in the holomorphic shear and overshear group of complex-Euklidean space and extend this result to the group of holomorphic automorphisms of Stein manifolds with Density Property, provided there exists a generalized translation. The conjugation operator associated to this generalized translation is hypercyclic on the topological space of holomorphic automorphisms.Comment: 9 page

Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts

The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20 copies of the cloned globin gene. Rabbit globin transcripts were detected in two of these transformants at steady-state concentrations of 5 and 2 copies per cell. The globin transcripts from one cell line are polyadenylylated and migrate as 9S RNA on methylmercury gels. These transcripts reflect correct processing of the two intervening sequences but lack 48 ± 5 nucleotides present at the 5' terminus of rabbit erythrocyte globin mRNA

QSO environments at intermediate redshifts

We have made a survey of quasar environments at 0.5 < z < 0.8, using a sample of both radio-loud and radio-quiet quasars matched in B-band luminosity. Our observations include images of background control fields to provide a good determination of the field galaxy counts. About 10 per cent of the quasars appear to live in rich clusters, whereas approximately 45 per cent live in environments similar to that of field galaxies. The richness of galaxies within a 0.5 Mpc radius around the radio-quiet quasars is found to be indistinguishable from the richness around the radio-loud quasars, corresponding on average to groups or poorer clusters of galaxies. Comparing the galaxy richness in the radio-loud quasar fields with quasar fields in the literature, we find no evidence of an evolution in the environment with epoch. Instead, a weak, but significant correlation between quasar radio luminosity and environmental richness is present. It is thus possible that the environments of quasars, at least the powerful ones, do not evolve much between the present epoch and z \approx 0.8.Comment: 6 pages, 4 figures, to appear in the proc. of the workshop `QSO hosts and their environments', IAA, Granada 10-12 Jan, 200

Changes from 1986 to 2006 in reasons for liking leisure-time physical activity among adolescents

Reasons for participating in physical activity (PA) may have changed in accordance with the general modernization of society. The aim is to examine changes in self-reported reasons for liking leisure-time physical activity (LTPA) and their association with self-reported LTPA over a 20-year period. Data were collected among nationally representative samples of 13-year-olds in Finland, Norway, and Wales in 1986 and 2006 (N = 9252) as part of the WHO cross-national Health Behaviour in School-aged Children (HBSC) study. Univariate ANOVAs to establish differences according to gender, year, and country were conducted. In all countries, 13-year-olds in 2006 tended to report higher importance in terms of achievement and social reasons than their counterparts in 1986, while changes in health reasons were minor. These reasons were associated with LTPA in a similar way at both time points. Health reasons for liking LTPA were considered most important, and were the strongest predictor of LTPA. The findings seem robust as they were consistent across countries and genders. Health education constitutes the most viable strategy for promoting adolescents' motivation for PA, and interventions and educational efforts could be improved by an increased focus on LTPA and sport as a social activity

Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart

Forced expression of the myogenic regulatory gene MyoD in many types of cultured cells initiates their conversion into skeletal muscle. It is not known, however, if MyoD expression serves to activate all or part of the skeletal muscle program in vivo during animal development, nor is it known how limiting the influences of cellular environment may be on the regulatory effects of MyoD. To begin to address these issues, we have produced transgenic mice which express MyoD in developing heart, where neither MyoD nor its three close relatives—myogenin, Myf-5, and MRF4/herculin/Myf-6—are normally expressed. The resulting gross phenotype in offspring from multiple, independent transgenic founders includes abnormal heart morphology and ultimately leads to death. At the molecular level, affected hearts exhibit activation of skeletal muscle-specific regulatory as well as structural genes. We conclude that MyoD is able to initiate the program that leads to skeletal muscle differentiation during mouse development, even in the presence of the ongoing cardiac differentiation program. Thus, targeted misexpression of this tissue-specific regulator during mammalian embryogenesis can activate, either directly or indirectly, a diverse set of genes normally restricted to a different cell lineage and a different cellular environment