128 research outputs found
Information Content in Decays and the Angular Moments Method
The time-dependent angular distributions of decays of neutral mesons into
two vector mesons contain information about the lifetimes, mass differences,
strong and weak phases, form factors, and CP violating quantities. A
statistical analysis of the information content is performed by giving the
``information'' a quantitative meaning. It is shown that for some parameters of
interest, the information content in time and angular measurements combined may
be orders of magnitude more than the information from time measurements alone
and hence the angular measurements are highly recommended. The method of
angular moments is compared with the (maximum) likelihood method to find that
it works almost as well in the region of interest for the one-angle
distribution. For the complete three-angle distribution, an estimate of
possible statistical errors expected on the observables of interest is
obtained. It indicates that the three-angle distribution, unraveled by the
method of angular moments, would be able to nail down many quantities of
interest and will help in pointing unambiguously to new physics.Comment: LaTeX, 34 pages with 9 figure
Dihydroazulene Photoswitch Operating in Sequential Tunneling Regime: Synthesis and Single-Molecule Junction Studies
Molecular switches play a central role for the development of molecular electronics. In this work it is demonstrated that the reproducibility and robustness of a single-molecule dihydroazulene (DHA)/vinylheptafulvene (VHF) switch can be remarkably enhanced if the switching kernel is weakly coupled to electrodes so that the electron transport goes by sequential tunneling. To assure weak coupling, the DHA switching kernel is modified by incorporating p-MeSC6H4 end-groups. Molecules are prepared by Suzuki cross-couplings on suitable halogenated derivatives of DHA. The synthesis presents an expansion of our previously reported brominationeliminationcross-coupling protocol for functionalization of the DHA core. For all new derivatives the kinetics of DHA/VHF transition has been thoroughly studied in solution. The kinetics reveals the effect of sulfur end-groups on the thermal ring-closure of VHF. One derivative, incorporating a p-MeSC6H4 anchoring group in one end, has been placed in a silver nanogap. Conductance measurements justify that transport through both DHA (high resistivity) and VHF (low resistivity) forms goes by sequential tunneling. The switching is fairly reversible and reenterable; after more than 20 ON-OFF switchings, both DHA and VHF forms are still recognizable, albeit noticeably different from the original states
SARS-CoV-2 placentitis and severe pregnancy outcome after maternal infection:A Danish case series
Real-world applicability and impact of early rhythm control for European patients with atrial fibrillation:a report from the ESC-EHRA EORP-AF Long-Term General Registry
Association of Self-reported Systemic Reactions Following SARS-CoV-2 Vaccination With Immunological Response in the Danish National Cohort Study of Effectiveness and Safety of SARS-CoV-2 Vaccines (ENFORCE)
Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity:A nationwide cohort study with validation of the SARS-CoV-2 diagnosis
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Abstract: Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. We hypothesized that experimental diabetes in rats combined with a cardiac or renal stressor, would mimic diabetic cardiomyopathy and nephropathy, respectively. Diabetes was surgically induced in male Sprague Dawley rats by 90% pancreatectomy (Px). Isoprenaline (Iso, 1 mg/kg, sc., 10 days) was administered 5 weeks after Px with the aim of inducing cardiomyopathy, and cardiac function and remodeling was assessed by echocardiography 10 weeks after surgery. Left ventricular (LV) fibrosis was quantified by Picro Sirius Red and gene expression analysis. Nephropathy was induced by Px combined with uninephrectomy (Px-UNx). Kidney function was assessed by measurement of glomerular filtration rate (GFR) and urine albumin excretion, and kidney injury was evaluated by histopathology and gene expression analysis. Px resulted in stable hyperglycemia, hypoinsulinemia, decreased C-peptide, and increased glycated hemoglobin (HbA1c) compared with sham-operated controls. Moreover, Px increased heart and LV weights and dimensions and caused a shift from α-myosin heavy chain (MHC) to β-MHC gene expression. Isoprenaline treatment, but not Px, decreased ejection fraction and induced LV fibrosis. There was no apparent interaction between Px and Iso treatment. The superimposition of Px and UNx increased GFR, indicating hyperfiltration. Compared with sham-operated controls, Px-UNx induced albuminuria and increased urine markers of kidney injury, including neutrophil gelatinase-associated lipocalin (NGAL) and podocalyxin, concomitant with upregulated renal gene expression of NGAL and kidney injury molecule 1 (KIM-1). Whereas Px and isoprenaline separately produced clinical endpoints related to diabetic cardiomyopathy, the combination of the two did not accentuate disease development. Conversely, Px in combination with UNx resulted in several clinical hallmarks of diabetic nephropathy indicative of early disease development
SARS-CoV-2 infection in pregnancy in Denmark—characteristics and outcomes after confirmed infection in pregnancy:A nationwide, prospective, population-based cohort study
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