Climate change, loss of (bio)diversity, natural ressource depletion, social marginalization etc: Our adaptation and mitigation contribution

The environmental and social challenges of the planet are a sad reality. Organic Agriculture advocates often espouse its contributions to mitigating the negative effects of farming. But mitigation alone is not enough. Farmers also need to adapt to a changed climate, reduced biodiversity and depleted resources as well as to an ever-changing socio-cultural environment

Caustic formation in a non-Gaussian model for turbulent aerosols

Caustics in the dynamics of heavy particles in turbulence accelerate particle collisions. The rate $\mathscr{J}$ at which these singularities form depends sensitively on the Stokes number St, the non-dimensional inertia parameter. Exact results for this sensitive dependence have been obtained using Gaussian statistical models for turbulent aerosols. However, direct numerical simulations of heavy particles in turbulence yield much larger caustic-formation rates than predicted by the Gaussian theory. In order to understand possible mechanisms explaining this difference, we analyse a non-Gaussian statistical model for caustic formation in the limit of small St. We show that at small St, $\mathscr{J}$ depends sensitively on the tails of the distribution of Lagrangian fluid-velocity gradients. This explains why different authors obtained different St-dependencies of $\mathscr{J}$ in numerical-simulation studies. The most-likely gradient fluctuation that induces caustics at small St, by contrast, is the same in the non-Gaussian and Gaussian models. Direct-numerical simulation results for particles in turbulence show that the optimal fluctuation is similar, but not identical, to that obtained by the model calculations.Comment: 12 pages, 3 figures, 1 tabl

Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB)

Many advances in the field of cancer biology have been made using mouse models of human cancer. The Mouse Tumor Biology (MTB, "http://tumor.informatics.jax.org":http://tumor.informatics.jax.org) database provides web-based access to data on spontaneous and induced tumors from genetically defined mice (inbred, hybrid, mutant, and genetically engineered strains of mice). These data include standardized tumor names and classifications, pathology reports and images, mouse genetics, genomic and cytogenetic changes occurring in the tumor, strain names, tumor frequency and latency, and literature citations.

Although primary source for the data represented in MTB is peer-reviewed scientific literature an increasing amount of data is derived from disparate sources. MTB includes annotated histopathology images and cytogenetic assay images for mouse tumors where these data are available from The Jackson Laboratory’s mouse colonies and from outside contributors. MTB encourages direct submission of mouse tumor data and images from the cancer research community and provides investigators with a web-accessible tool for image submission and annotation. 

Integrated searches of the data in MTB are facilitated by the use of several controlled vocabularies and by adherence to standard nomenclature. MTB also provides links to other related online resources such as the Mouse Genome Database, Mouse Phenome Database, the Biology of the Mammary Gland Web Site, Festing's Listing of Inbred Strains of Mice, the JAX® Mice Web Site, and the Mouse Models of Human Cancers Consortium's Mouse Repository. 

MTB provides access to data on mouse models of cancer via the internet and has been designed to facilitate the selection of experimental models for cancer research, the evaluation of mouse genetic models of human cancer, the review of patterns of mutations in specific cancers, and the identification of genes that are commonly mutated across a spectrum of cancers.

MTB is supported by NCI grant CA089713

Small-molecule control of cytokine function: new opportunities for treating immune disorders

Manipulating cytokine function with protein-based drugs has proven effective for treating a wide variety of autoimmune and autoinflammatory disorders. However, the limited ability of protein-based drugs to modulate intracellular targets, including many implicated by studies of the genetics and physiology of these diseases, and to coordinately neutralize redundant inflammatory cytokines, suggests an important and complementary role for small molecules in immunomodulatory drug development. The recent clinical approval of Janus kinase and phosphodiesterase inhibitors, along with emerging evidence from other compound classes, firmly establish small molecules as effective tools for modulating therapeutically relevant proteins that give rise to aberrant cytokine signaling or mediate its downstream consequences

Biomechanical determination of distal level for fusions across the cervicothoracic junction

Study Design In vitro testing. Objective To determine whether long cervical and cervicothoracic fusions increase the intradiscal pressure at the adjacent caudal disk and to determine which thoracic end vertebra causes the least increase in the adjacent-level intradiscal pressure. Methods A bending moment was applied to six cadaveric cervicothoracic spine specimens with intact rib cages. Intradiscal pressures were recorded from C7–T1 to T9–10 before and after simulated fusion by anterior cervical plating and posterior thoracic pedicle screw constructs. The changes in the intradiscal pressure from baseline were calculated and compared. Results No significant differences where found when the changes of the juxtafusion intradiscal pressure at each level were compared for the flexion, extension, and left and right bending simulations. However, combining the pressures for all directions of bending at each level demonstrated a decrease in the pressures at the T2–T3 level. Exploratory analysis comparing changes in the pressure at T2–T3 to other levels showed a significant decrease in the pressures at this level (p = 0.005). Conclusions Based on the combined intradiscal pressures alone it may be advantageous to end long constructs spanning the cervicothoracic junction at the T2 level if there are no other mitigating factors

Trust \u3ci\u3eThe Key to Leading When Lives Are on the Line\u3c/i\u3e

The Hostage Rescue Team (HRT) of the Federal Bureau of Investigation was called in to assist the bureau\u27s Special Weapons and Tactics (SWAT) team in Memphis to apprehend a married couple wanted on drug trafficking charges. The fugitive couple and an adult son, all with criminal records, were believed to be living in trailers in a mountain valley where outsiders would be easily noticed. The fugitives were known to stockpile weapons and had vowed never to be taken alive by law enforcement. Thus the FBI considered them to be armed and extremely dangerous. Two HRT snipers along with two SWAT snipers were given the mission of positively identifying the fugitives and providing security and containment for the assault force. The snipers would have to travel several kilometers through wooded, mountainous terrain using night vision goggles (NVGs). The SWAT snipers did not have nighttime, overland movement capability, which is why HRT was brought in

Fueling of a marine-terrestrial ecosystem by a major seabird colony

Seabirds redistribute nutrients between different ecosystem compartments and over vast geographical areas. This nutrient transfer may impact both local ecosystems on seabird breeding islands and regional biogeochemical cycling, but these processes are seldom considered in local conservation plans or biogeochemical models. The island of Stora Karlso in the Baltic Sea hosts the largest concentration of piscivorous seabirds in the region, and also hosts a large colony of insectivorous House martins Delichon urbicum adjacent to the breeding seabirds. We show that a previously reported unusually high insectivore abundance was explained by large amounts of chironomids-highly enriched in delta N-15-that feed on seabird residues as larvae along rocky shores to eventually emerge as flying adults. Benthic ammonium and phosphate fluxes were up to 163% and 153% higher close to the colony (1,300 m distance) than further away (2,700 m) and the estimated nutrient release from the seabirds at were in the same order of magnitude as the loads from the largest waste-water treatment plants in the region. The trophic cascade impacting insectivorous passerines and the substantial redistribution of nutrients suggest that seabird nutrient transfer should be increasingly considered in local conservation plans and regional nutrient cycling models.Peer reviewe