125 research outputs found
On Spatial Consensus Formation: Is the Sznajd Model Different from a Voter Model?
In this paper, we investigate the so-called ``Sznajd Model'' (SM) in one
dimension, which is a simple cellular automata approach to consensus formation
among two opposite opinions (described by spin up or down). To elucidate the SM
dynamics, we first provide results of computer simulations for the
spatio-temporal evolution of the opinion distribution , the evolution of
magnetization , the distribution of decision times and
relaxation times . In the main part of the paper, it is shown that the
SM can be completely reformulated in terms of a linear VM, where the transition
rates towards a given opinion are directly proportional to frequency of the
respective opinion of the second-nearest neighbors (no matter what the nearest
neighbors are). So, the SM dynamics can be reduced to one rule, ``Just follow
your second-nearest neighbor''. The equivalence is demonstrated by extensive
computer simulations that show the same behavior between SM and VM in terms of
, , , , and the final attractor statistics. The
reformulation of the SM in terms of a VM involves a new parameter , to
bias between anti- and ferromagnetic decisions in the case of frustration. We
show that plays a crucial role in explaining the phase transition
observed in SM. We further explore the role of synchronous versus asynchronous
update rules on the intermediate dynamics and the final attractors. Compared to
the original SM, we find three additional attractors, two of them related to an
asymmetric coexistence between the opposite opinions.Comment: 22 pages, 20 figures. For related publications see
http://www.ais.fraunhofer.de/~fran
Are ipsilateral breast tumour invasive recurrences in young (⩽40 years) women more aggressive than their primary tumours?
The characteristics of ipsilateral breast tumour recurrences (IBTRs) relative to those of their primary tumours (PTs) remain scarcely studied. Of 70 young (⩽40 years) premenopausal women with IBTRs, we studied a series of 63 with paired histological data. Median follow-up since IBTR was 10 years. Rates of histological types, grades or hormonal receptors were not significantly different in PTs and in IBTRs. The concordance between IBTRs and their PTs was good for histological types. IBTRs with conserved histological types tended to occur more locally, but not significantly sooner than others. These IBTRs had good concordance for hormone receptors. In discordant cases there were as many losses as appearances of the receptors. The concordance was weak for grades, with equivalent numbers of IBTRs graded lower as higher than their PTs. The 10-year overall survival rate was 70%. Neither the conservation of histological type, location, nor of the two combined were associated with deaths. Early (<2 years) IBTRs, tended to be associated with poorer survival (HR=2.24 (0.92–5.41); P=0.08). IBTRs did not display features of higher aggressiveness than PTs. Neither clinical nor histological definition of a true recurrence could be established other than the conservation of the histological type
Beyond the Evidence of the New Hypertension Guidelines. Blood pressure measurement – is it good enough for accurate diagnosis of hypertension? Time might be in, for a paradigm shift (I)
Despite widespread availability of a large body of evidence in the area of hypertension, the translation of that evidence into viable recommendations aimed at improving the quality of health care is very difficult, sometimes to the point of questionable acceptability and overall credibility of the guidelines advocating those recommendations. The scientific community world-wide and especially professionals interested in the topic of hypertension are witnessing currently an unprecedented debate over the issue of appropriateness of using different drugs/drug classes for the treatment of hypertension. An endless supply of recent and less recent "drug-news", some in support of, others against the current guidelines, justifying the use of selected types of drug treatment or criticising other, are coming out in the scientific literature on an almost weekly basis. The latest of such debate (at the time of writing this paper) pertains the safety profile of ARBs vs ACE inhibitors. To great extent, the factual situation has been fuelled by the new hypertension guidelines (different for USA, Europe, New Zeeland and UK) through, apparently small inconsistencies and conflicting messages, that might have generated substantial and perpetuating confusion among both prescribing physicians and their patients, regardless of their country of origin. The overwhelming message conveyed by most guidelines and opinion leaders is the widespread use of diuretics as first-line agents in all patients with blood pressure above a certain cut-off level and the increasingly aggressive approach towards diagnosis and treatment of hypertension. This, apparently well-justified, logical and easily comprehensible message is unfortunately miss-obeyed by most physicians, on both parts of the Atlantic. Amazingly, the message assumes a universal simplicity of both diagnosis and treatment of hypertension, while ignoring several hypertension-specific variables, commonly known to have high level of complexity, such as: - accuracy of recorded blood pressure and the great inter-observer variability, - diversity in the competency and training of diagnosing physician, - individual patient/disease profile with highly subjective preferences, - difficulty in reaching consensus among opinion leaders, - pharmaceutical industry's influence, and, nonetheless, - the large variability in the efficacy and safety of the antihypertensive drugs. The present 2-series article attempts to identify and review possible causes that might have, at least in part, generated the current healthcare anachronism (I); to highlight the current trend to account for the uncertainties related to the fixed blood pressure cut-off point and the possible solutions to improve accuracy of diagnosis and treatment of hypertension (II)
Phylogeny and classification of the East Asian Amitostigma alliance (Orchidaceae: Orchideae) based on six DNA markers
Are breast conservation and mastectomy equally effective in the treatment of young women with early breast cancer? Long-term results of a population-based cohort of 1,451 patients aged ≤40 years
Review of UHF-Based Signal Processing Approaches for Partial Discharge Detection
Partial Discharge (PD) events are due to local defects in dielectrics and can cause damages to the electrical insulation and eventually to the whole power station. This paper reviews approaches describing procedures and numerical techniques for detecting, denoising, clustering, and classifying PDs in the ultra-high frequency range. For each method the mathematical background is recalled and one or few representative examples from selected papers are shortly described
Kunitz-Type Proteinase Inhibitors Derived by Limited Proteolysis of the Inter-α-Trypsin Inhibitor, II. Characterization of a Second Inhibitory Inactive Domain by Amino Acid Sequence Determination
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