22 research outputs found

    One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG

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    Abstract: α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity

    One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG

    No full text
    α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity
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