In-Vitro Anthelmintic Potential Of Aqueous And Ethanolic Leaves And Roots Extracts Of Annona Muricata Against Earthworm

Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases considered as Neglected Tropical Diseases that infect around two billion people worldwide. Many of synthetic drugs available, for the treatment of various worm infection like alendazole, mebendazole and Ivermectn with more of adverse effects so the need of herbal formulations are essential for teating worm infections.Plants have been used as anthelmintic from ancient times. In our study we selected Annona muricata is well known traditional plant which is used for the treatement of many worm infection without adverse effect.Phytochemical screening was conducted using standard qualitative methods, it reveals that they were rich in secondary metabolite compounds such as alkaloids, saponins, tannins, flavonoids. The in-vitro anthelmintic activity was determined using earthworm. In this ethanolic exctract of 200 mg/ml concentration shows high anthelmintic activity when compared to other concentration of Annona Muricata leaves extrac

Non-phosgene route for the synthesis of methyl phenyl carbamate using ordered AISBA-15 catalyst

Methyl phenyl carbamate (MPC) has been synthesized under liquid phase conditions from dimethyl carbonate and aniline by using mesoporous AlSBA-15 catalyst. The catalyst with different Si/Al ratio was synthesized by isomorphous substitution of aluminium into the framework of siliceous SBA-15. The structural integrity of the catalyst system was diagnosed with the help of various characterization techniques such as X-ray diffraction, surface analysis, and the acidity measurement has been done by TPD using ammonia as probe molecule. AlSBA-15 (Si/Al = 10) exhibited highest catalytic activity in the synthesis of MPC under the reaction conditions studied. The effect of parameters such as molar ratio of reactants, catalyst concentration, reaction temperature and time on the conversion of aniline was investigated. The results demonstrated that an aniline conversion of 99% and MPC selectivity of 71% were achieved when the reaction was carried out at 100 °C, DMC to aniline mole ratio of 10 with 5% of catalyst (wt% of total reaction mixture) for 3 h

The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry : towards a new function for the peptide in the brain

The tachykinin neuropeptide family, which includes substance P and neurokinin B, is involved in a wide array of biological functions. Among these is the ability to protect against the neurotoxic processes in Alzheimer’s Disease, but the mechanisms driving neuroprotection remain unclear. Dysregulation of metal ions, particularly copper, iron and zinc is a common feature of Alzheimer’s Disease, and other amyloidogenic disorders. Copper is known to be released from neurons and recent work has shown that some tachykinins can bind Cu(II) ions, and that neurokinin B can inhibit copper uptake into astrocytes. We have now examined whether neurokinin B is capable of binding Cu(I), which is predicted to be available in the synapse. Using a combination of spectroscopic techniques including cyclic voltammetry and magnetic resonance we show that neurokinin B can bind Cu(I) either directly from added CuCl or by reduction of Cu(II)-bound neurokinin B. The results showed that the Cu(I) binding site differs greatly to that of Cu(II) and involves thioether coordination via Met2 and Met10 and an imidazole nitrogen ligand from His3. The Cu(I) coordination is also different to the site adopted by Ag(I). During changes in oxidation state, copper remains bound to neurokinin B despite large changes to the inner coordination sphere. We predict that neurokinin B may be involved in synaptic copper homeostasis