Perinatal maternal and neonatal behaviour in\ud the captive reticulated giraffe

A captive reticulated giraffe was observed constantly for three weeks prior to, and periodically for 90 days subsequent to, the birth of her calf. Extensive observations were made of the birth sequence, feeding, drinking, sleeping and one instance of an infant distress call, as well as observations of the initiation of maternal behaviour (including licking, nursing, placentophagia, and what appeared to be helping the calf to stand, guiding the calf's movements, and attempts to respond to the calf's distress call)

Effects of Medial Preoptic Lesions on\ud Placentophagia and on the Onset of Maternal\ud Behavior in the Rat

Lesions of the medial preoptic area (MPO) were produced through permanently indwelling electrodes 24 hr prior to parturition in pregnant rats, or 24 hr prior to donor-placenta presentation in virgin rats determined in a pretest to be placentophages. The lesions had no disruptive effect on placentophagia in the virgin females. However, MPO lesions did delay the onset of placentophagia, pup-retrieval, and nestbuilding in some parturient rats. In others, lesions produced an impairment (in latency and quality) only of nest-building. None showed any impairment of pup-licking, or in the clear tendency to leave excreted waste away from the gathered pups. These results suggest the possibility of at least semi-independent mechanisms for the various components of maternal behavior

The Relationship between Implicit and Explicit Processing in Statistical Language Learning

Statistical language learning is an implicit process wherein language learners track sequential statistics in fluent speech, and may it facilitate the learning of word boundaries. This process is well studied, however, the cognitive mechanisms supporting it remain poorly understood. The present thesis investigated whether domain-specific or cross-domain explicit working memory engagement would impair implicit statistical learning of word boundaries in fluent speech. Participants (n = 110) were exposed to an implicit statistical word segmentation paradigm while concurrently engaged in no other task (control), or an explicit domain- specific (verbal) or cross-domain (visuospatial) working memory task of either low- or high- demand. Participants in the control task and either visuospatial task (low- and high-demand) reliably segmented words from the artificial language, however those in either verbal working memory condition (low- and high-demand) did not. These findings suggest an interference effect on implicit verbal learning by explicit processing of material from the same domain

Exploring the Process of Statistical Language Learning

In this thesis, I investigated the process of statistical word segmentation using a combination of behavioural, clinical, and neuroimaging approaches. Prior research has largely focused on the outcome of statistical learning approaches, with little research attention paid to the process of learning. In this body of research, I sought to address this issue. In Chapter 2, I examined how domain-specific and domain-general working memory interference effects on a statistical word segmentation task. I found that when completing a concurrent visuospatial or verbal working memory task, statistical language learning was impaired. Thus, this study provided some evidence that domain-general working memory may support statistical language learning. In Chapter 3, I further investigated how cognitive processes, including language and working memory, are involved in statistical learning across domains. In this study, school-aged children with and without a developmental language disorder (DLD) completed a statistical language learning task and a visual statistical learning task. I found that those with DLD did not differ from typically developing children on either statistical learning task, and that performance across groups was meager for the statistical language learning task, and not above chance levels for the visual statistical learning task. Further, performance on the statistical learning tasks was not associated with other cognitive processes. This raised the possibility that an alternative measurement approach may be better suited to examine statistical learning. I addressed this issue in Chapter 4, where I measured event related potentials (ERPs) using electroencephalography (EEG) during exposure to a structured, unsegmented language. I found that statistical learning performance was related to neural responses to the structured linguistic input, and that ERPs were modulated as a function of language exposure, revealing the dynamic nature of statistical learning. Chapter 5 discusses the relevant findings of this thesis in relation to the current state of affairs in statistical learning research, and presents recommendations for future research in examining the process of statistical learning

On the relationship between the “default mode network” and the “social brain”

The default mode network (DMN) of the brain consists of areas that are typically more active during rest than during active task performance. Recently however, this network has been shown to be activated by certain types of tasks. Social cognition, particularly higher-order tasks such as attributing mental states to others, has been suggested to activate a network of areas at least partly overlapping with the DMN. Here, we explore this claim, drawing on evidence from meta-analyses of functional MRI data and recent studies investigating the structural and functional connectivity of the social brain. In addition, we discuss recent evidence for the existence of a DMN in non-human primates. We conclude by discussing some of the implications of these observations

Nested Case–Control Study of Autoimmune Disease in an Asbestos-Exposed Population

OBJECTIVE: To explore the potential association between asbestos exposure and risk of autoimmune disease, we conducted a case–control study among a cohort of 7,307 current and former residents of Libby, Montana, a community with historical occupational and environmental exposure to asbestos-contaminated vermiculite. METHODS: Cases were defined as those who reported having one of three systemic autoimmune diseases (SAIDs): systemic lupus erythematosus, scleroderma, or rheumatoid arthritis (RA). Controls were randomly selected at a 3:1 ratio from among the remaining 6,813 screening participants using frequency-matched age and sex groupings. RESULTS: The odds ratios (ORs) and 95% confidence intervals (CIs) for SAIDs among those ≥ 65 years of age who had worked for the vermiculite mining company were 2.14 (95% CI, 0.90–5.10) for all SAIDs and 3.23 (95% CI, 1.31–7.96) for RA. In this age group, exposure to asbestos while in the military was also an independent risk factor, resulting in a tripling in risk. Other measures of occupational exposure to vermiculite indicated 54% and 65% increased risk for SAIDs and RA, respectively. Those who had reported frequent contact with vermiculite through various exposure pathways also demonstrated elevated risk for SAIDs and RA. We found increasing risk estimates for SAIDs with increasing numbers of reported vermiculite exposure pathways (p < 0.001). CONCLUSION: These preliminary findings support the hypothesis that asbestos exposure is associated with autoimmune disease. Refined measurements of asbestos exposure and SAID status among this cohort will help to further clarify the relationship between these variables

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.

We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European American MS patients and 419 ethnically matched controls, using next-generation sequencing. The DRB1*15:01~DQB1*06:02 haplotype was highly predisposing (odds ratio (OR) = 3.98; 95% confidence interval (CI) = 3-5.31; p-value (p) = 2.22E-16), as was DRB1*03:01~DQB1*02:01 (OR = 1.63; CI = 1.19-2.24; p = 1.41E-03). Hardy-Weinberg (HW) analysis in MS patients revealed a significant DRB1*03:01~DQB1*02:01 homozyote excess (15 observed; 8.6 expected; p = 0.016). The OR for this genotype (5.27; CI = 1.47-28.52; p = 0.0036) suggests a recessive MS risk model. Controls displayed no HW deviations. The C*03:04~B*40:01 haplotype (OR = 0.27; CI = 0.14-0.51; p = 6.76E-06) was highly protective for MS, especially in haplotypes with A*02:01 (OR = 0.15; CI = 0.04-0.45; p = 6.51E-05). By itself, A*02:01 is moderately protective, (OR = 0.69; CI = 0.54-0.87; p = 1.46E-03), and haplotypes of A*02:01 with the HLA-B Thr80 Bw4 variant (Bw4T) more so (OR = 0.53; CI = 0.35-0.78; p = 7.55E-04). Protective associations with the Bw4 KIR ligand resulted from linkage disequilibrium (LD) with DRB1*15:01, but the Bw4T variant was protective (OR = 0.64; CI = 0.49-0.82; p = 3.37-04) independent of LD with DRB1*15:01. The Bw4I variant was not associated with MS. Overall, we find specific class I HLA polymorphisms to be protective for MS, independent of the strong predisposition conferred by DRB1*15:01

Behaviours preceding suicides at railway and underground locations: a multimethodological qualitative approach

Background: Suicides by train have devastating consequences for families, the rail industry, staff dealing with the aftermath of such incidents, and potential witnesses. To reduce suicides and suicide attempts by rail it is important to learn how safe interventions can be made. However, very little is known about how to identify someone who may be about to make a suicide attempt at a railway location (including underground/subways). The current research employed a novel way of understanding what behaviours might immediately precede a suicide or suicide attempt at these locations. Design and Methods: A qualitative thematic approach was used for three parallel studies. Data were gathered from several sources including: interviews with individuals who survived a suicide attempt at a railway or underground location (N=9); CCTV footage of individuals who died by suicide at a rail or underground location (N=16); and qualitative survey data providing views from rail staff (N=79). Results: Our research suggests there are several behaviours that people may carry out before a suicide or suicide attempt at a rail location including: station hopping and platform switching; limiting contact with others; positioning themselves at the end of the track where the train/tube approaches; allowing trains to pass by; and carrying out repetitive behaviours. Interpretation: There are several behaviours that may be identifiable in the moments leading up to a suicide or suicide attempt on the railways, which may present opportunities for intervention. These findings have implications for several stakeholders including rail providers, transport police and other organisations focused on suicide prevention

The Existing Legal Infrastructure of BRICs: Where Have We Been and Where Are We Going

The focus of this panel is incrementally shifting from the previous panel. Whereas the previous was looking at public/private issues and issues relating to incentivizing innovation in the subject countries, we\u27re going to take a focus more on, I think it\u27s safe to say, from an external perspective looking at these countries and issues that are confronted by businesses who our either planning to deal with the four subject countries or are concerned about their technologies being used in their four subject countries. We have four panelists, and each of them is going to speak to one of the four countries. We\u27re going to start with Julie Lee from Foley & Lardner, and she\u27s going to be looking at special issues relating to China. And following that we\u27re going to be hearing from Robert Ahdieh, who is at Emory Law School. His focus is going to be in particular on Russia. We\u27re then going to turn to Srividhya Ragavan, and she\u27s with the University of Oklahoma College of Law. She\u27s going to be addressing in particular India. And we\u27re going to end by having Kevin talk to us, and his focus is going to be nominally on Brazil, though his experience has been fairly far-reaching so he will no doubt address some of the issues that apply to all four of the subject countries