Platelet Alloantibody Specificities in Multiply Transfused Patients.

Transfusion plays an important role in the management of patients with hematological malignancies and disorders. Patients during the induction chemotherapy may need multiple transfusion of platelets and red cells and may develop refractoriness; platelet count increment deteriorate even after adequate dose of platelets are transfused. Although several studies reported non-immunological factors like fever, Splenomegaly, septicemia and severe bleeding are responsible for refractoriness in some patients, no specific reasons can be found. This raises the suspicion of platelet antibodies for the cause of refractoriness. Till now in many studies, the presence of HLA and platelet specific antibodies were found to be between 10%-60%in the patients who were treated with multiple transfusions. Our results concluded that multiple random donor blood and platelet transfusion are able to induce antibodies against HLA class 1 antigens and epitopes on GP iib/iiia. There was no relationship between the number of units transfused and the antibodies formation. Women with single pregnancy history were identified as high responder group for alloimmunization. Our results show AML are frequently immunized than ALL patients. Keeping in view the alloimmunization, leukoreduced irradiated single donor platelets and blood components should be transfused for the treatment of hematological and oncological patients. Till now, non-leukoreduced components are used in most of the centers in India due to cost of leukoreduction. Testing for the presence of platelet antibodies and transfusion of compatible platelets shall be important mode of management and prevention of platelet refractoriness in India

Implementation of Driver Software of Trailer Module Chip

The aim of the project is to develop a driver software for UJA1076A SBC in embedded C using IAR Embedded Workbench and integrate the driver software with application software of Trailer module. Currently MC33903 system basis chip from Freescale is used in Trailer Module. As an initiative to reduce the material cost for the Trailer module product, a lower price SBC NXP UJA1076A has been used. Also due to the fact that the newly proposed SBC has less number of operating modes and registers to configure, it helps in making the driver software much more simpler, thus reducing the risk of hidden issues in the otherwise complex design and code of the current SBC driver software

Correlation between Hand Tripod Pinch Grip and Handwriting Quality impact on Academic Performance- A Narrative Review

Background: Hand is an important structure used for reaching, holding object predominantly for that grasp and grip strength particularly tripod pinch grip strength is very essential and handwriting is one of the skilled fine motor movements in that deft handwriting which include particular speed with legible writing product is needed for students especially for their higher grades to achieve their best academic performance. Objective: Deft Handwriting is an essential functional skill that impacts on Academic performance and progress from primary school level to higher grades, mostly assumed that grasp and tripod pinch grip affects legibility, speed, yet research studies examining this relationship as correlation are limited. Method: We used Narrative review methodology to map existing research on tripod pinch grip and handwriting quality from the school-age children to higher grades and to identify gaps in the literature. Results: Ten articles met search criteria and were categorized by grasp patterns which mainly include tripod –dynamic tripod grip strength and handwriting performance in speed and readability and grasp kinetics and handwriting performance. Findings suggest an inefficient grasp can lead to decreased handwriting quality i.e legibility and speed. The current literature is inconclusive and several gaps were identified. Conclusion: Tripod pinch grip strength consider as an important since the thump ,index and middle finger its fine motor action , pressure and force exerted on the pencil since static and dynamic tripod pinch commonly used with students if the student lack of this factor finally end in the low academic performance which affect their higher grades, hence Early Analysis at the primary level and early intervention with maintain the higher grades consider as an essential factor reveals from the article. &nbsp

Bioinformatics in crosslinking chemistry of collagen with selective cross linkers

<p>Abstract</p> <p>Background</p> <p>Identifying the molecular interactions using bioinformatics tools before venturing into wet lab studies saves the energy and time considerably. The present study summarizes, molecular interactions and binding energy calculations made for major structural protein, collagen of Type I and Type III with the chosen cross-linkers, namely, coenzyme Q₁₀, dopaquinone, embelin, embelin complex-1 & 2, idebenone, 5-O-methyl embelin, potassium embelate and vilangin.</p> <p>Results</p> <p>Molecular descriptive analyses suggest, dopaquinone, embelin, idebenone, 5-O-methyl embelin, and potassium embelate display nil violations. And results of docking analyses revealed, best affinity for Type I (- 4.74 kcal/mol) and type III (-4.94 kcal/mol) collagen was with dopaquinone.</p> <p>Conclusions</p> <p>Among the selected cross-linkers, dopaquinone, embelin, potassium embelate and 5-O-methyl embelin were the suitable cross-linkers for both Type I and Type III collagen and stabilizes the collagen at the expected level.</p

Human protein reference database—2006 update

Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data

Understanding our seas: National Institute of Oceanography, Goa

The present article summarizes the research done at the CSIR–National Institute of Oceanography in 2014 in ocean science, resources and technology. Significant research has been conducted on air–sea interactions and coastal circulation, biogeochemistry, biology, marine geophysics, palaeoceanography, marine fishery, gas hydrates and wave energy. Technological advances covered topics like oceanographic tools. Major strides have been made in marine resources research and evaluation

Early diagnosis is associated with improved clinical outcomes in benign esophageal perforation: an individual patient data meta‑analysis

Background Time of diagnosis (TOD) of benign esophageal perforation is regarded as an important risk factor for clinical outcome, although convincing evidence is lacking. The aim of this study is to assess whether time between onset of perforation and diagnosis is associated with clinical outcome in patients with iatrogenic esophageal perforation (IEP) and Boerhaave’s syndrome (BS). Methods We searched MEDLINE, Embase and Cochrane library through June 2018 to identify studies. Authors were invited to share individual patient data and a meta-analysis was performed (PROSPERO: CRD42018093473). Patients were subdivided in early (≤ 24 h) and late (> 24 h) TOD and compared with mixed effects multivariable analysis while adjusting age, gender, location of perforation, initial treatment and center. Primary outcome was overall mortality. Secondary outcomes were length of hospital stay, re-interventions and ICU admission. Results Our meta-analysis included IPD of 25 studies including 576 patients with IEP and 384 with BS. In IEP, early TOD was not associated with overall mortality (8% vs. 13%, OR 2.1, 95% CI 0.8–5.1), but was associated with a 23% decrease in ICU admissions (46% vs. 69%, OR 3.0, 95% CI 1.2–7.2), a 22% decrease in re-interventions (23% vs. 45%, OR 2.8, 95% CI 1.2–6.7) and a 36% decrease in length of hospital stay (14 vs. 22 days, p < 0.001), compared with late TOD. In BS, no associations between TOD and outcomes were found. When combining IEP and BS, early TOD was associated with a 6% decrease in overall mortality (10% vs. 16%, OR 2.1, 95% CI 1.1–3.9), a 19% decrease in re-interventions (26% vs. 45%, OR 1.9, 95% CI 1.1–3.2) and a 35% decrease in mean length of hospital stay (16 vs. 22 days, p = 0.001), compared with late TOD. Conclusions This individual patient data meta-analysis confirms the general opinion that an early (≤ 24 h) compared to a late diagnosis (> 24 h) in benign esophageal perforations, particularly in IEP, is associated with improved clinical outcome.publishedVersio

Measurement of the photon polarization in Λb→Λγ\Lambda_b \to \Lambda \gamma decays

The photon polarization in $b \to s \gamma$ transitions is measured for the first time in radiative b-baryon decays exploiting the unique spin structure of $\Lambda_b \to \Lambda \gamma$ decays. A data sample corresponding to an integrated luminosity of $6\;fb^{-1}$ collected by the LHCb experiment in $pp$ collisions at a center-of-mass energy of $13\;TeV$ is used. The photon polarization is measured to be $\alpha_{\gamma}= 0.82^{\,+\,0.17\,+\,0.04}_{\,-\,0.26\,-\,0.13}$, where the first uncertainty is statistical and the second systematic. This result is in agreement with the Standard Model prediction and previous measurements in b-meson decays. Charge-parity breaking effects are studied for the first time in this observable and found to be consistent with $CP$ symmetry.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2021-030.html (LHCb public pages