Homotopy Method for the Large, Sparse, Real Nonsymmetric Eigenvalue Problem

A homotopy method to compute the eigenpairs, i.e., the eigenvectors and eigenvalues, of a given real matrix A1 is presented. From the eigenpairs of some real matrix A0, the eigenpairs of A(t) ≡ (1 − t)A0 + tA1 are followed at successive "times" from t = 0 to t = 1 using continuation. At t = 1, the eigenpairs of the desired matrix A1 are found. The following phenomena are present when following the eigenpairs of a general nonsymmetric matrix: • bifurcation, • ill conditioning due to nonorthogonal eigenvectors, • jumping of eigenpaths. These can present considerable computational difficulties. Since each eigenpair can be followed independently, this algorithm is ideal for concurrent computers. The homotopy method has the potential to compete with other algorithms for computing a few eigenvalues of large, sparse matrices. It may be a useful tool for determining the stability of a solution of a PDE. Some numerical results will be presented

Autonomous resource-aware scheduling of large-scale media workflows

The media processing and distribution industry generally requires considerable resources to be able to execute the various tasks and workflows that constitute their business processes. The latter processes are often tied to critical constraints such as strict deadlines. A key issue herein is how to efficiently use the available computational, storage and network resources to be able to cope with the high work load. Optimizing resource usage is not only vital to scalability, but also to the level of QoS (e.g. responsiveness or prioritization) that can be provided. We designed an autonomous platform for scheduling and workflow-to-resource assignment, taking into account the different requirements and constraints. This paper presents the workflow scheduling algorithms, which consider the state and characteristics of the resources (computational, network and storage). The performance of these algorithms is presented in detail in the context of a European media processing and distribution use-case

Morphological Properties of PPNs: Mid-IR and HST Imaging Surveys

We will review our mid-infrared and HST imaging surveys of the circumstellar dust shells of proto-planetary nebulae. While optical imaging indirectly probes the dust distribution via dust-scattered starlight, mid-IR imaging directly maps the distribution of warm dust grains. Both imaging surveys revealed preferencially axisymmetric nature of PPN dust shells, suggesting that axisymmetry in planetary nebulae sets in by the end of the asymptotic giant branch phase, most likely by axisymmetric superwind mass loss. Moreover, both surveys yielded two morphological classes which have one-to-one correspondence between the two surveys, indicating that the optical depth of circumstellar dust shells plays an equally important role as the inclination angle in determining the morphology of the PPN shells.Comment: 6 pages + 8 figures, to appear in the proceedings of the conference, "Post-AGB Objects (proto-planetary nebulae) as a Phase of Stellar Evolution", Torun, Poland, July 5-7, 2000, eds. R. Szczerba, R. Tylenda, and S.K. Gorny. Figures have been degraded to minimize the total file siz

The Radon Monitoring System in Daya Bay Reactor Neutrino Experiment

We developed a highly sensitive, reliable and portable automatic system (H$^{3}$) to monitor the radon concentration of the underground experimental halls of the Daya Bay Reactor Neutrino Experiment. H$^{3}$ is able to measure radon concentration with a statistical error less than 10\% in a 1-hour measurement of dehumidified air (R.H. 5\% at 25$^{\circ}$C) with radon concentration as low as 50 Bq/m$^{3}$. This is achieved by using a large radon progeny collection chamber, semiconductor $\alpha$-particle detector with high energy resolution, improved electronics and software. The integrated radon monitoring system is highly customizable to operate in different run modes at scheduled times and can be controlled remotely to sample radon in ambient air or in water from the water pools where the antineutrino detectors are being housed. The radon monitoring system has been running in the three experimental halls of the Daya Bay Reactor Neutrino Experiment since November 2013

Early real-time estimation of the basic reproduction number of emerging or reemerging infectious diseases in a community with heterogeneous contact pattern: Using data from Hong Kong 2009 H1N1 Pandemic Influenza as an illustrative example

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Thermal Comfort in a Naturally Ventilated and Air Conditioned Urban Arcade

Thermal comfort research in office buildings has led to developments in new thermal comfort standards. Yet a review of thermal comfort research reveals a lack of information on human response to conditions in transitional spaces: courts, atria, and arcades; spaces influenced by the outdoors, but bounded by a building or conditioned space. This study focuses on one type of transitional space, the urban arcade. Adapting methods from past field research of indoor thermal comfort, we collected data using two techniques: survey questionnaires and physical measurement. Subjects walked through two arcades and completed a thermal comfort survey. To quantify the thermal conditions of the arcade, we designed a measurement cart, containing equipment and sensors that took measurements of the physical environment as subjects completed surveys. The arcades of Cleveland, Ohio served as a case study in which 25 occupants completed questionnaires in two arcades, one naturally ventilated, the other air-conditioned. In general, the thermal environmental conditions of the arcades met the specifications of current thermal comfort standards. A wide range of votes and large deviation between votes characterized thermal sensation voting of occupants

Class II ADP-ribosylation factors are required for efficient secretion of Dengue viruses

This article is available open access through the publisher’s website.Identification and characterization of virus-host interactions are very important steps toward a better understanding of the molecular mechanisms responsible for disease progression and pathogenesis. To date, very few cellular factors involved in the life cycle of flaviviruses, which are important human pathogens, have been described. In this study, we demonstrate a crucial role for class II Arf proteins (Arf4 and Arf5) in the dengue flavivirus life cycle. We show that simultaneous depletion of Arf4 and Arf5 blocks recombinant subviral particle secretion for all four dengue serotypes. Immunostaining analysis suggests that class II Arf proteins are required at an early pre-Golgi step for dengue virus secretion. Using a horseradish peroxidase protein fused to a signal peptide, we show that class II Arfs act specifically on dengue virus secretion without altering the secretion of proteins through the constitutive secretory pathway. Co-immunoprecipitation data demonstrate that the dengue prM glycoprotein interacts with class II Arf proteins but not through its C-terminal VXPX motif. Finally, experiments performed with replication-competent dengue and yellow fever viruses demonstrate that the depletion of class II Arfs inhibits virus secretion, thus confirming their implication in the virus life cycle, although data obtained with West Nile virus pointed out the differences in virus-host interactions among flaviviruses. Our findings shed new light on a molecular mechanism used by dengue viruses during the late stages of the life cycle and demonstrate a novel function for class II Arf proteins.Research Fund for Control of Infectious Diseases of Hong Kong and BNP Paribas Corporate and Investment Banking