Peranan Pembayangan pada Courtyard terhadap Pengendalian Suhu Permukaan (Studi Kasus Gedung Widya Puraya Universitas Diponegoro Semarang)

Courtyard merupakan komponen bangunan sejak lampau yang memiliki fungsi sebagai elemen estetika di dalam bangunan juga berperan dalam usaha menciptakan sistem pengkondisian udara dan pencahayaan alami. Sebagai bukaan tentunya penetrasi radiasi matahari langsung ke dalam bangunan tidak dapat di hindari akan tetapi dengan bentuk struktur yang khas dari courtyard ditambah dengan ketersediaan elemen vegetasi akan membentuk bidang-bidang bayangan. Tulisan ini bertujuan untuk memberikan pemaparan hasil penelitian mengenai sejauh mana peranan pembayangan pada courtyard dalam mereduksi peningkatan suhu permukaan akibat dari penetrasi radiasi matahari. Metode yang digunakan pada penilitan ini adalah analisis secara kualitatif terhadap data kuantitatif hasil observasi dan pengukuran langsung terhadap obyek studi.  Dari hasil analisis dapat diketahui bahwa variasi bidang pembayangan dan durasi pembayangan pada area courtyard gedung Widya Puraya Universitas Diponego dapat mengendalikan peningkatan suhu permukaan yang dipengaruhi oleh durasi puncak peningkatan suhu permukaan.   Kata Kunci : Pembayangan, Courtyard, Suhu Permukaa

Relaxation and Guided Imagery Significantly Reduces Androgen Levels and Distress in Polycystic Ovary Syndrome: Pilot Study

AIM: Women with polycystic ovary syndrome (PCOS) often have elevated levels of the androgen testosterone, and are at increased risk of anxiety and depression. This study aimed to use psychological relaxation with guided imagery to decrease androgen levels and improve mood in PCOS. METHODS: Repeated-measures. Thirteen women with PCOS underwent six weekly treatment sessions, and a follow-up session, of calming breathing, muscle relaxation, and guided imagery. The main outcome measures were mood and quality of life (QoL) – assessed using validated questionnaires – and hormones, which were assayed in serum using tandem mass spectrometry. RESULTS: There was a small but statistically significant reduction in DHEAS from before to after Week 1 (p <.044) and from before to after Week 6 (p <.001). From before to after Week 6 there were also small but statistically significant reductions in androstenedione (p <.010) and cortisol (p <.003). From Week 1 to Week 6 there was a significant reduction in anxiety (p <.037). There was a significant improvement in depression from Week 1 to Week 6 (p <.034) and from Week 1 to follow-up (p <.011). There were no significant changes in free or total testosterone, nor in QoL. CONCLUSIONS: This is the first study to use a relaxation programme to reduce adrenal androgens in PCOS

Why, or Why Not, Be an Originalist?

On November 15, 2019, the Federalist Society hosted the second showcase panel of the 2019 National Lawyers Convention at the Mayflower Hotel in Washington, DC. The topic of the panel was “Why, or Why Not, Be an Originalist?” There are a variety of arguments for following originalism today, such as justifications rooted in language, positivism, sovereignty, and consequences. This panel would look at many normative positions for and against originalism

Crocodiles and grey nomads: a deadly combination?

Increasing numbers of retirees seek individual, extended, unstructured activities in remote, non-commercial locations. Travel is predominantly by self-drive 4WD vehicle towing a caravan/campervan. These ‘grey nomads’ often prefer remote bush camping sites/caravan parks to commercial resorts. The tropics – a popular destination – are inhabited by Australia’s only large semi-terrestrial carnivore, the estuarine crocodile Crocodylus porosus. Conservation programmes of recent decades have resulted in a substantial increase in numbers. With naive grey nomads increasingly encroaching on crocodile territory, attacks are expected to increase. Review of conservation programmes to incorporate awareness education targeting grey nomads is therefore required

The Effect of Thawing Protocols on Follicle Conservation in Human Ovarian Tissue Cryopreservation

BACKGROUND: Ovarian tissue cryopreservation has the potential to improve fertility preservation for a growing number of patients undergoing sterilising therapy, particularly where oocyte or embryo cryopreservation is not suitable. However, its success is limited by significant follicular apoptosis upon thawing, and there is wide variation in thawing protocols used with little evidence of efficacy. OBJECTIVE: To determine the best warming rates to maintain tissue viability. MATERIALS AND METHODS: Ovarian tissue biopsies from 11 patients were taken with informed consent and divided into four pieces, which were allocated to either fresh assessment or to one of several freeze-thaw protocols. Cryopreservation was undertaken using a Stirling cycle cryo-cooler and cryopreserved samples were exposed to different warming protocols. Tissue conservation was then assessed using a marker, neutral red, to identify viable follicles. RESULTS: The results showed greatest follicle conservation rates in fresh samples, followed by those thawed using a rapid thawing protocol (Protocol 1). Tissue thawed using an ultra fast protocol (Protocol 2) and slow warming (Protocol 3) resulted in greater follicle loss. CONCLUSION: These preliminary results indicate thawing conditions significantly affect follicle conservation in cryopreserved human ovarian tissue

Where are the Pots and Pans? Collective Responses in Ireland to Neoliberalization in a Time of Crisis: Learning from Latin America

Since 2008, Ireland has experienced a profound multi-faceted crisis, stemming from the collapse of the financial and property sectors. Despite enduring six years of neoliberal austerity measures in response to this situation, popular protest has been muted. Using Silva's [(2009) Challenging Neoliberalism in Latin America (Cambridge and New York: Cambridge University Press)] framework of analysis of popular responses in Latin America to that region's debt crisis of the 1980s and 1990s, this article seeks to investigate why this has been the case. We assess how the crisis is being framed among popular and civil society groups, and whether increased associational and collective power is developing. In doing so, we look at processes of intra-group cooperation, cross-group cooperation and framing and brokerage mechanisms. We then ask, where such processes exist, if they can lead to a comprehensive challenge to the neoliberal policies currently being implemented, as happened in much of Latin America. We conclude that the crisis has not yet reached sufficient depth or longevity to foster a more robust popular response, but propose that analysis of similar processes in Latin America can help us understand better why this is the case, not just in Ireland, but in other countries of Europe experiencing similar situations

A comparative framework: how broadly applicable is a 'rigorous' critical junctures framework?

The paper tests Hogan and Doyle's (2007, 2008) framework for examining critical junctures. This framework sought to incorporate the concept of ideational change in understanding critical junctures. Until its development, frameworks utilized in identifying critical junctures were subjective, seeking only to identify crisis, and subsequent policy changes, arguing that one invariably led to the other, as both occurred around the same time. Hogan and Doyle (2007, 2008) hypothesized ideational change as an intermediating variable in their framework, determining if, and when, a crisis leads to radical policy change. Here we test this framework on cases similar to, but different from, those employed in developing the exemplar. This will enable us determine whether the framework's relegation of ideational change to a condition of crisis holds, or, if ideational change has more importance than is ascribed to it by this framework. This will also enable us determined if the framework itself is robust, and fit for the purposes it was designed to perform — identifying the nature of policy change

A multi-dating approach to age-modelling long continental records: The 135 ka El Cañizar de Villarquemado sequence (NE Spain)

We present the multidisciplinary dating approach - including radiocarbon, Uranium/Thorium series (U/Th), paleomagnetism, single-grain Optical Stimulated Luminescence (OSL), Infrared Stimulated Luminescence (IRSL) and tephrochronology - used for the development of an age model for the Cañizar de Villarquemado sequence (VIL) for the last ca. 135 ka. We describe the protocols used for each technique and discuss the positive and negative results, as well as their implications for interpreting the VIL sequence and for dating similar terrestrial records. In spite of the negative results of some techniques, particularly due to the absence of adequate sample material or inaccurate analytical precision, the multi-technique strategy employed here is essential to maximize the chances of obtaining robust age models in terrestrial sequences. The final Bayesian age model for VIL sequence includes 16 AMS 14C ages, 9 OSL ages and 5 previously published IRSL ages, and the accuracy and resolution of the model are improved by incorporating information related to changes in accumulation rate, as revealed by detailed sedimentological analyses. The main paleohydrological and vegetation changes in the sequence are coherent with global Marine Isotope Stage (MIS) 6 to 1 transitions since the penultimate Termination, although some regional idiosyncrasies are evident, such as higher moisture variability than expected, an abrupt inception of the last glacial cycle and a resilient response of vegetation in Mediterranean continental Iberia in both Terminations

RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord

ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons. No meaningful therapies exist to slow ALS progression, and molecular insights into pathogenesis and progression are sorely needed. In that context, we used high-depth, next generation RNA sequencing (RNAseq, Illumina) to define gene network abnormalities in RNA samples depleted of rRNA and isolated from cervical spinal cord sections of 7 ALS and 8 CTL samples. We aligned \u3e50 million 2X150 bp paired-end sequences/sample to the hg19 human genome and applied three different algorithms (Cuffdiff2, DEseq2, EdgeR) for identification of differentially expressed genes (DEG’s). Ingenuity Pathways Analysis (IPA) and Weighted Gene Co-expression Network Analysis (WGCNA) identified inflammatory processes as significantly elevated in our ALS samples, with tumor necrosis factor (TNF) found to be a major pathway regulator (IPA) and TNFα-induced protein 2 (TNFAIP2) as a major network “hub” gene (WGCNA). Using the oPOSSUM algorithm, we analyzed transcription factors (TF) controlling expression of the nine DEG/hub genes in the ALS samples and identified TF’s involved in inflammation (NFkB, REL, NFkB1) and macrophage function (NR1H2::RXRA heterodimer). Transient expression in human iPSC-derived motor neurons of TNFAIP2 (also a DEG identified by all three algorithms) reduced cell viability and induced caspase 3/7 activation. Using high-density RNAseq, multiple algorithms for DEG identification, and an unsupervised gene co-expression network approach, we identified significant elevation of inflammatory processes in ALS spinal cord with TNF as a major regulatory molecule. Overexpression of the DEG TNFAIP2 in human motor neurons, the population most vulnerable to die in ALS, increased cell death and caspase 3/7 activation. We propose that therapies targeted to reduce inflammatory TNFα signaling may be helpful in ALS patients