A Tale of Two Theories: Quantum Griffiths Effects in Metallic Systems

We show that two apparently contradictory theories on the existence of Griffiths-McCoy singularities in magnetic metallic systems [1,2] are in fact mathematically equivalent. We discuss the generic phase diagram of the problem and show that there is a non-universal crossover temperature range T* < T < W where power law behavior (Griffiths-McCoy behavior) is expect. For T<T* power law behavior ceases to exist due to the destruction of quantum effects generated by the dissipation in the metallic environment. We show that T* is an analogue of the Kondo temperature and is controlled by non-universal couplings.Comment: 4 pages, 2 figure

Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function

BACKGROUND: Endoglin/CD105 is an auxiliary receptor for transforming growth factor-β with established roles in vascular remodelling. It has recently been shown that heterozygous endoglin deficiency in mice decreases insulin secretion in an animal model of obesity, highlighting a potential role for endoglin in the regulation of islet function. We have previously identified two different populations of endoglin expressing cells in human and mouse islets which are: (i) endothelial cells (ECs) and (ii) islet mesenchymal stromal cells. The contribution of islet EC endoglin expression to islet development and sensitivity to VEGF is unknown and is the focus of this study. RESULTS: In vitro culture of mouse islets with VEGF164 for 48 h increased endoglin mRNA levels above untreated controls but VEGF did not modulate VEGFR2, CD31 or CD34 mRNA expression or islet viability. Removal of EC-endoglin expression in vivo reduced islet EC area but had no apparent effect on islet size or architecture. CONCLUSION: EC-specific endoglin expression in islets is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size

Discovery of a very X-ray luminous galaxy cluster at z=0.89 in the WARPS survey

We report the discovery of the galaxy cluster ClJ1226.9+3332 in the Wide Angle ROSAT Pointed Survey (WARPS). At z=0.888 and L_X=1.1e45 erg/s (0.5-2.0 keV, h_0=0.5) ClJ1226.9+3332 is the most distant X-ray luminous cluster currently known. The mere existence of this system represents a huge problem for Omega_0=1 world models. At the modest (off-axis) resolution of the ROSAT PSPC observation in which the system was detected, ClJ1226.9+3332 appears relaxed; an off-axis HRI observation confirms this impression and rules out significant contamination from point sources. However, in moderately deep optical images (R and I band) the cluster exhibits signs of substructure in its apparent galaxy distribution. A first crude estimate of the velocity dispersion of the cluster galaxies based on six redshifts yields a high value of 1650 km/s, indicative of a very massive cluster and/or the presence of substructure along the line of sight. While a more accurate assessment of the dynamical state of this system requires much better data at both optical and X-ray wavelengths, the high mass of the cluster has already been unambiguously confirmed by a very strong detection of the Sunyaev-Zel'dovich effect in its direction (Joy et al. 2001). Using ClJ1226.9+3332 and ClJ0152.7-1357 (z=0.835), the second-most distant X-ray luminous cluster currently known and also a WARPS discovery, we obtain a first estimate of the cluster X-ray luminosity function at 0.8<z<1.4 and L_X>5e44 erg/s. Using the best currently available data, we find the comoving space density of very distant, massive clusters to be in excellent agreement with the value measured locally (z<0.3), and conclude that negative evolution is not required at these luminosities out to z~1. (truncated)Comment: accepted for publication in ApJ Letters, 6 pages, 2 figures, uses emulateapj.st

Flux networks in metabolic graphs

A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved metabolite property such as molecular weight. A similar flux network can be constructed by combining the primal and dual solutions to the linear programming problem that typically arises in constraint-based modelling. Such constructions may help with the visualisation of flux distributions in complex metabolic networks. The analysis also explains the strong correlation observed between metabolite shadow prices (the dual linear programming variables) and conserved metabolite properties. The methods were applied to recent metabolic models for Escherichia coli, Saccharomyces cerevisiae, and Methanosarcina barkeri. Detailed results are reported for E. coli; similar results were found for the other organisms.Comment: 9 pages, 4 figures, RevTeX 4.0, supplementary data available (excel

The WARPS survey - IV: The X-ray luminosity-temperature relation of high redshift galaxy clusters

We present a measurement of the cluster X-ray luminosity-temperature relation out to high redshift (z~0.8). Combined ROSAT PSPC spectra of 91 galaxy clusters detected in the Wide Angle ROSAT Pointed Survey (WARPS) are simultaneously fit in redshift and luminosity bins. The resulting temperature and luminosity measurements of these bins, which occupy a region of the high redshift L-T relation not previously sampled, are compared to existing measurements at low redshift in order to constrain the evolution of the L-T relation. We find a best fit to low redshift (z1 keV, to be L proportional to T^(3.15\pm0.06). Our data are consistent with no evolution in the normalisation of the L-T relation up to z~0.8. Combining our results with ASCA measurements taken from the literature, we find eta=0.19\pm0.38 (for Omega_0=1, with 1 sigma errors) where L_Bol is proportional to (1 + z)^eta T^3.15, or eta=0.60\pm0.38 for Omega_0=0.3. This lack of evolution is considered in terms of the entropy-driven evolution of clusters. Further implications for cosmological constraints are also discussed.Comment: 11 pages, 7 figures, accepted for publication in MNRA