Nucleon electromagnetic form factors in two-flavour QCD

We present results for the nucleon electromagnetic form factors, including the momentum transfer dependence and derived quantities (charge radii and magnetic moment). The analysis is performed using O(a) improved Wilson fermions in Nf=2 QCD measured on the CLS ensembles. Particular focus is placed on a systematic evaluation of the influence of excited states in three-point correlation functions, which lead to a biased evaluation, if not accounted for correctly. We argue that the use of summed operator insertions and fit ans\"atze including excited states allow us to suppress and control this effect. We employ a novel method to perform joint chiral and continuum extrapolations, by fitting the form factors directly to the expressions of covariant baryonic chiral effective field theory. The final results for the charge radii and magnetic moment from our lattice calculations include, for the first time, a full error budget. We find that our estimates are compatible with experimental results within their overall uncertainties.Comment: 22 pages, 10 figures, citations modifie

Nucleon axial form factors from two-flavour Lattice QCD

We present preliminary results on the axial form factor $G_A(Q^2)$ and the induced pseudoscalar form factor $G_P(Q^2)$ of the nucleon. A systematic analysis of the excited-state contributions to form factors is performed on the CLS ensemble `N6' with $m_\pi = 340 \ \text{MeV}$ and lattice spacing $a \sim 0.05 \ \text{fm}$. The relevant three-point functions were computed with source-sink separations ranging from $t_s \sim 0.6 \ \text{fm}$ to $t_s \sim \ 1.4 \ \text{fm}$. We observe that the form factors suffer from non-trivial excited-state contributions at the source-sink separations available to us. It is noted that naive plateau fits underestimate the excited-state contributions and that the method of summed operator insertions correctly accounts for these effects.Comment: 7 pages, 12 figures; talk presented at Lattice 2014 -- 32nd International Symposium on Lattice Field Theory, 23-28 June, 2014, Columbia University New York, N

Universality of the rho-meson coupling in effective field theory

It is shown that both the universal coupling of the rho-meson and the Kawarabayashi-Suzuki-Riadzuddin-Fayyazuddin expression for the magnitude of its coupling constant follow from the requirement that chiral perturbation theory of pions, nucleons, and rho-mesons is a consistent effective field theory. The prerequisite of the derivation is that all ultraviolet divergences can be absorbed in the redefinition of fields and the available parameters of the most general effective Lagrangian.Comment: 4 pages, 2 figures, REVTeX 4, accepted for publication in PR

Chiral effective field theories of the strong interactions

Effective field theories of the strong interactions based on the approximate chiral symmetry of QCD provide a model-independent approach to low-energy hadron physics. We give a brief introduction to mesonic and baryonic chiral perturbation theory and discuss a number of applications. We also consider the effective field theory including vector and axial-vector mesons.Comment: 22 pages, 9 figures, proceedings of "Many-Body Structure of Strongly Interacting Systems", Mainz, Germany, Feb. 23-25 201

Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects

We have investigated the expression of cell surface markers and leucocyte cell adhesion molecules by immunohistochemistry in bronchial biopsies from 10 mild atopic asthmatics and 8 normal, nonatopic subjects. Significantly increased numbers of eosinophils (p<0.01) were evident in the bronchial submucosa of asthmatic subjects. In epithelium there were more CD44+ (p<0.02) and lymphocyte function-associated antigen-1 (LFA-1)+ (p<0.06) leucocytes in asthmatics than in normal subjects. Bronchial epithelial cells stained positively with anti-CD44 monoclonal antibodies (moAb) in both groups; however, when the staining was expressed as percentage of the total basement membrane, a considerable and highly significant increase was observed in the asthmatics (median 80 vs 22%, p=0.003). Few leucocytes were positive for very late activation antigen (VLA)-1, VLA-2 and VLA-4. The moAb for VLA-6 stained the basement membrane of the bronchial epithelium; while intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were constitutively expressed in endothelium. A positive correlation was found between LFA-1+ cells and activated eosinophils (EG2+) in the submucosa (p<0.005; r(s)=0.80). We conclude that even in mild asthma there is evidence of increased expression of cell surface ligands, and suggest that adhesive mechanisms play a role both in cell recruitment and disease activity.peer-reviewe

Finite volume corrections to the electromagnetic current of the nucleon

We compute corrections to both the isovector anomalous magnetic moment and the isovector electromagnetic current of the nucleon to $O(p^3)$ in the framework of covariant two-flavor Baryon Chiral Perturbation Theory. We then apply these corrections to lattice data for the anomalous magnetic moment from the LHPC, RBC & UKQCD and QCDSF collaborations

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED

RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies and epithelial brushings of 107 moderate-to-severe asthmatics were annotated by gene-set variation analysis (GSVA) using 42 gene-signatures relevant to asthma, inflammation and immune function. Topological data analysis (TDA) of clinical and histological data was used to derive clusters and the nearest shrunken centroid algorithm used for signature refinement. RESULTS: 9 GSVA signatures expressed in bronchial biopsies and airway epithelial brushings distinguished two distinct asthma subtypes associated with high expression of T-helper type 2 (Th-2) cytokines and lack of corticosteroid response (Group 1 and Group 3). Group 1 had the highest submucosal eosinophils, high exhaled nitric oxide (FeNO) levels, exacerbation rates and oral corticosteroid (OCS) use whilst Group 3 patients showed the highest levels of sputum eosinophils and had a high BMI. In contrast, Group 2 and Group 4 patients had an 86% and 64% probability of having non-eosinophilic inflammation. Using machine-learning tools, we describe an inference scheme using the currently-available inflammatory biomarkers sputum eosinophilia and exhaled nitric oxide levels along with OCS use that could predict the subtypes of gene expression within bronchial biopsies and epithelial cells with good sensitivity and specificity. CONCLUSION: This analysis demonstrates the usefulness of a transcriptomic-driven approach to phenotyping that segments patients who may benefit the most from specific agents that target Th2-mediated inflammation and/or corticosteroid insensitivity

Electromagnetic superconductivity of vacuum induced by strong magnetic field

The quantum vacuum may become an electromagnetic superconductor in the presence of a strong external magnetic field of the order of 10^{16} Tesla. The magnetic field of the required strength (and even stronger) is expected to be generated for a short time in ultraperipheral collisions of heavy ions at the Large Hadron Collider. The superconducting properties of the new phase appear as a result of a magnetic-field-assisted condensation of quark-antiquark pairs with quantum numbers of electrically charged rho mesons. We discuss similarities and differences between the suggested superconducting state of the quantum vacuum, a conventional superconductivity and the Schwinger pair creation. We argue qualitatively and quantitatively why the superconducting state should be a natural ground state of the vacuum at the sufficiently strong magnetic field. We demonstrate the existence of the superconducting phase using both the Nambu-Jona-Lasinio model and an effective bosonic model based on the vector meson dominance (the rho-meson electrodynamics). We discuss various properties of the new phase such as absence of the Meissner effect, anisotropy of superconductivity, spatial inhomogeneity of ground state, emergence of a neutral superfluid component in the ground state and presence of new topological vortices in the quark-antiquark condensates.Comment: 37 pages, 14 figures, to appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Ye