Experiences of Autism Diagnosis: Parental Experiences and Interpretations of the Process of Having a Child Diagnosed with Autism

The experience of having a child diagnosed with ASD is known to be challenging for parents, and research on this has been increasing over the past decade. This study provides a thematic analysis of the lived experience of having a child diagnosed with ASD, based on interviews with seven parents (aged 35 to 52 years) of six children (aged 7 to 13) who had received a diagnosis of ASD within five years of starting primary school. Parents described the experience of having a child diagnosed with ASD as raising questions and issues in four interconnected areas of concern: “seeing the child”, “navigating the professional system”, “accommodating the needs of the child in balance with the needs of the whole family” and “helping the child find a way of being in the world”. For parents, receiving a diagnosis of ASD involved a challenge of “meaning” – a challenge of integrating the information about their child provided in the diagnosis with their sense of who their child is. Parents were particularly appreciative of professionals who assisted them with this task and who showed an appreciation of the unique qualities of their children. The experiences of these parents have implications for how professionals might communicate with parents and families, as well as how they can provide clear and definite information, address some core practical concerns of parents and families and at all times show an appreciation of the child

Some Reflections on Developments in German Employee Codetermination Since 1976

The latest German law on the codetermination of Supervisory Boards came into effect in July 1976. In one sense it was a major advance in the development of codetermination which some argue began 128 years previously when in 1848 the Constitutional National Assembly first established factory committees with certain rights of worker participation. It was also a compromise result of intensive political discussion and activity particularly in the period after Willy Brandt declared in 1973 that codetermination would be one of the 'main tasks' of his government. Germany industry has had a two-tier Board system since the 1880s. Under the provisions of the 1976 Act companies with more than 2,000 employees (481 enterprises in 1980) must have a Supervisory Board ('Aufsichtsrat') with equal representation for labour and capital, and an Executive Board ('Vorstard'). Under previous legislation (1952, 1972) the labour representation on the Supervisory Boards of joint stock companies (AG) had been limited to one third. The duties of the Supervisory Board include the appointment of the members of the Executive Board, one of whom must be a Labour Director (' Arbeitsdirektor')

Personalize News Recommendation System by Using Stack Auto Encoder

The popularity of Internet and mobile Internet, people are facing serious information overloading problems now a days. Recommendation engine is very useful to help people to reach the Internet news they want through the network. Recommender Systems have become the vital role in recent years and are utilized widely in various areas of social importance. In day to day life, users will not be able to read news every day due to heavy schedule. So to increase General knowledge of users we propose online recommendation systems which recommend news. In existing system i.e. news delivery portals deliver popular news on home page of the portal but user’s data according recommendation is not implemented yet. To overcome existing system problems we propose new recommendation system which automatically finds the news based on user’s profiles. Using the stack auto encoder algorithm

Some Reflections on Developments in German Employee Codetermination Since 1976

The latest German law on the codetermination of Supervisory Boards came into effect in July 1976. In one sense it was a major advance in the development of codetermination which some argue began 128 years previously when in 1848 the Constitutional National Assembly first established factory committees with certain rights of worker participation. It was also a compromise result of intensive political discussion and activity particularly in the period after Willy Brandt declared in 1973 that codetermination would be one of the 'main tasks' of his government. Germany industry has had a two-tier Board system since the 1880s. Under the provisions of the 1976 Act companies with more than 2,000 employees (481 enterprises in 1980) must have a Supervisory Board ('Aufsichtsrat') with equal representation for labour and capital, and an Executive Board ('Vorstard'). Under previous legislation (1952, 1972) the labour representation on the Supervisory Boards of joint stock companies (AG) had been limited to one third. The duties of the Supervisory Board include the appointment of the members of the Executive Board, one of whom must be a Labour Director (' Arbeitsdirektor')

Reviews

Review of Worker Control and Influence: A Review of the Bullock Report, The Report of the Commission of Inquiry into the Heavy Engineering Industry, Wage Payment System

Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity

Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast cancer. c-Src activity in ‘pure' ductal carcinoma in situ (DCIS) was measured to assess whether this predicts recurrence and/or correlates with HER2 expression and other clinical parameters. Activated c-Src levels were evaluated in DCIS biopsies from 129 women, with median follow-up at 60 months. High levels of activated c-Src correlated with HER2 positivity, high tumour grade, comedo necrosis and elevated epithelial proliferation. In univariate analysis, high activated c-Src level associated with lower recurrence-free survival at 5 years (P=0.011). Thus, high c-Src activity may identify a subset of DCIS with high risk of recurrence or progression to invasive cancer where therapeutics targeting c-Src may benefit this patient subset

How liquid biopsies can change clinical practice in oncology

Abstract Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a variety of clinical applications. ctDNA is being used to genotype solid cancers non-invasively, to track tumor dynamics and to detect the emergence of drug resistance. In a few settings, liquid biopsies have already entered clinical practice. For example, ctDNA is used to guide treatment in a subset of lung cancers. In this review, we discuss how recent improvements in the sensitivity and accuracy of ctDNA analyses have led to unprecedented advances in this research field. We further consider what is required for the routine deployment of liquid biopsies in the clinical diagnostic space. We pinpoint technical hurdles that liquid biopsies have yet to overcome, including preanalytical and analytical challenges. We foresee how liquid biopsies will transform clinical practice: by complementing (or replacing) imaging to monitor treatment response and by detecting minimal residual disease after surgery with curative intent

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes.2. Syntheses and biological activities of 1,4-dialkyl-,1,4-dibenzyl and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1' H-imidazol-2'yl)piperazines and isosteric analogues of imidazoline

International audienc