An Ultraluminous Supersoft X-ray Source in M81: An Intermediate-Mass Black Hole?

Ultraluminous supersoft X-ray sources (ULSSS) exhibit supersoft spectra with blackbody temperatures of 50-100 eV and bolometric luminosities above $10^{39}$ erg s$^{-1}$, and are possibly intermediate mass black holes (IMBHs) of $\ge10^3 M_\odot$ or massive white dwarfs that are progenitors of type Ia supernovae. In this letter we report our optical studies of such a source in M81, M81-ULS1, with HST archive observations. M81-ULS1 is identified with a point-like object, the spectral energy distribution of which reveals a blue component in addition to the companion of an AGB star. The blue component is consistent with the power-law as expected from the geometrically-thin accretion disk around an IMBH accretor, but inconsistent with the power-law as expected from the X-ray irradiated flared accretion disk around a white dwarf accretor. This result is strong evidence that M81-ULS1 is an IMBH instead of a white dwarf.Comment: 12 pages, 1 table, 3 figure

Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates.

Feature selection has been extensively studied in the context of goal-directed behavior, where it is heavily driven by top-down factors. A more primitive version of this function is the detection of bottom-up changes in stimulus features in the environment. Indeed, the nervous system is tuned to detect fast-rising, intense stimuli that are likely to reflect threats, such as nociceptive somatosensory stimuli. These stimuli elicit large brain potentials maximal at the scalp vertex. When elicited by nociceptive laser stimuli, these responses are labeled laser-evoked potentials (LEPs). Although it has been shown that changes in stimulus modality and increases in stimulus intensity evoke large LEPs, it has yet to be determined whether stimulus displacements affect the amplitude of the main LEP waves (N1, N2, and P2). Here, in three experiments, we identified a set of rules that the human nervous system obeys to identify changes in the spatial location of a nociceptive stimulus. We showed that the N2 wave is sensitive to: (1) large displacements between consecutive stimuli in egocentric, but not somatotopic coordinates; and (2) displacements that entail a behaviorally relevant change in the stimulus location. These findings indicate that nociceptive-evoked vertex potentials are sensitive to behaviorally relevant changes in the location of a nociceptive stimulus with respect to the body, and that the hand is a particularly behaviorally important site

The Discovery of an X-ray/UV Stellar Flare from the Late-K/Early-M Dwarf LMC 335

We report the discovery of an X-ray/UV stellar flare from the source LMC 335, captured by XMM-Newton in the field of the Large Magellanic Cloud. The flare event was recorded continuously in X-ray for its first 10 hours from the precursor to the late decay phases. The observed fluxes increased by more than two orders of magnitude at its peak in X-ray and at least one in the UV as compared to quiescence. The peak 0.1-7.0 keV X-ray flux is derived from the two-temperature APEC model to be ~(8.4 +/- 0.6) x 10^-12 erg cm-2 s-1. Combining astrometric information from multiple X-ray observations in the quiescent and flare states, we identify the NIR counterpart of LMC 335 as the 2MASS source J05414534-6921512. The NIR color relations and spectroscopic parallax characterize the source as a Galactic K7-M4 dwarf at a foreground distance of (100 - 264) pc, implying a total energy output of the entire event of ~(0.4 - 2.9) x 10^35 erg. This report comprises detailed analyses of this late-K / early-M dwarf flare event that has the longest time coverage yet reported in the literature. The flare decay can be modeled with two exponential components with timescales of ~28 min and ~4 hours, with a single component decay firmly ruled out. The X-ray spectra during flare can be described by two components, a dominant high temperature component of ~40-60MK and a low temperature component of ~10MK, with a flare loop length of about 1.1-1.3 stellar radius.Comment: 35 pages, 6 figures, 5 tables, accepted for publication in Ap

Influence of Storage Media on Color Stability of Different Resin Composites as Determined by \u394E and \u394E00

Objective: To evaluate the color stability of 3 different resin composites when exposed to storage in water, air or artificial saliva. Materials and Methods: Initial color of 81 specimens was assessed by a calibrated reflectance spectrophotometer over a black as well as a white background. Specifically, 9 disc shaped specimens made out of 3 resin composite materials were kept in distilled water, air and artificial saliva (Glandosane) at 37\ub0C. After a storage period of 4 weeks, spectrophotometric measurements were repeated and the color changes calculated by means of \u394E and \u394E00. Results: When analysed over a white background, median \u394E values varied from 0.6 (Filtek Supreme Dentin/water) to 7.1 (Filtek Supreme Enamel/Glandosane). When analysed over a black background median \u394E values varied from 0.4 (Filtek Supreme Dentin/water) to 5.0 (Filtek Supreme Enamel/Glandosane). When analysed over a white background, median \u394E00 values varied from 0.4 (Filtek Supreme Dentin/water) to 4.6 (Filtek Supreme Enamel/Glandosane). When analysed over a black background median \u394E00 values varied from 0.4 (Filtek Supreme Dentin/water) to 4.6 (Filtek Supreme Enamel/Glandosane). Statistical analysis performed by means of ANOVA and Fisher\u2019s LSD post hoc tests showed differences between groups. The correlation between \u394E and \u394E00 was 99.09% and 99.65% over black and white background, respectively. Conclusion: Within the limits of the present study, storage media significantly influenced color stability of resin composites

Bacterial–viral load and the immune response in stable and exacerbated COPD: Significance and therapeutic prospects

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and an abnormal inflammatory response of the lung. Bacteria and viruses are a major cause of COPD exacerbations and may contribute to COPD progression by perpetuating the inflammatory response in the airways. Bacterial variety diminishes with increasing COPD severity. Respiratory viruses can colonize the lower respiratory tract in stable COPD, altering the respiratory microbiome and facilitating secondary bacterial infections. In this review, we present the most updated information about the role of bacteria and viruses in stable and exacerbated COPD. In our opinion, to optimize therapeutic strategies, the dynamic events involving bacterial–viral infections and related immune response in COPD phenotypes need to be better clarified. Our paper would address these points that we consider of great importance for the clinical management of COPD

Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome

The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS).Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 healthy women (controls) matched for age and body mass index were studied. A complete hormonal assay was performed in each subject. Serum insulin and glucose levels were measured at baseline and after the oral glucose tolerance test. Plasma endothelin-1 levels and serum lipid profile were also assessed. The endothelial function was studied by flow-mediated dilation on the brachial artery, and arterial structure was evaluated by intima-media thickness measurement using Doppler ultrasound of both common carotid arteries.A significant (P < 0.05) difference in flow-mediated dilation (14.3 +/- 1.9% vs. 18.1 +/- 2.0% for PCOS patients and controls, respectively) and in intima-media thickness (0.53 +/- 0.09 mm vs. 0.39 +/- 0.08 mm for PCOS patients and controls, respectively) was found between PCOS and control subjects. Serum endothelin-1 levels were also significantly (P < 0.05) higher in PCOS patients compared with controls (1.1 +/- 0.4 pmol/liter vs. 0.5 +/- 0.2 pmol/liter for PCOS patients and controls, respectively).In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function

Emergence of entanglement from a noisy environment: The case of polaritons

We show theoretically that polariton pairs with a high degree of polarization entanglement can be produced through parametric scattering. We demonstrate that it can emerge in coincidence experiments, even at low excitation densities where the dynamics is dominated by incoherent photoluminesce. Our analysis is based on a microscopic quantum statistical approach that treats coherent and incoherent processes on an equal footing, thus allowing for a quantitative assessment of the amount of entanglement under realistic experimental conditions. This result puts forward the robustness of pair correlations in solid-state devices, even when noise dominates one-body correlations.Comment: revised version. new figure

Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates.

Feature selection has been extensively studied in the context of goal-directed behavior, where it is heavily driven by top-down factors. A more primitive version of this function is the detection of bottom-up changes in stimulus features in the environment. Indeed, the nervous system is tuned to detect fast-rising, intense stimuli that are likely to reflect threats, such as nociceptive somatosensory stimuli. These stimuli elicit large brain potentials maximal at the scalp vertex. When elicited by nociceptive laser stimuli, these responses are labeled laser-evoked potentials (LEPs). Although it has been shown that changes in stimulus modality and increases in stimulus intensity evoke large LEPs, it has yet to be determined whether stimulus displacements affect the amplitude of the main LEP waves (N1, N2, and P2). Here, in three experiments, we identified a set of rules that the human nervous system obeys to identify changes in the spatial location of a nociceptive stimulus. We showed that the N2 wave is sensitive to: (1) large displacements between consecutive stimuli in egocentric, but not somatotopic coordinates; and (2) displacements that entail a behaviorally relevant change in the stimulus location. These findings indicate that nociceptive-evoked vertex potentials are sensitive to behaviorally relevant changes in the location of a nociceptive stimulus with respect to the body, and that the hand is a particularly behaviorally important site