Intestinal absorption of glucose and insulin response in the pig: effect of supplementation with a low vs high viscosity seaweed fibre

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Bacterial status is a key-factor controlling expression of the mitochondrial HMG-CoA synthase gene in the rat intestinal mucosa

International audienc

Effect of algal fibre supplementation (Eucheuma cottonii) on intestinal absorption of glucose and insulin response in the pig

International audienc

Cerebral folate deficiency: Analytical tests and differential diagnosis

Cerebral folate deficiency is typically defined as a deficiency of the major folate species 5-methyltetrahydrofolate in the cerebrospinal fluid (CSF) in the presence of normal peripheral total folate levels. However, it should be noted that cerebral folate deficiency is also often used to describe conditions where CSF 5-MTHF is low, in the presence of low or undefined peripheral folate levels. Known defects of folate transport are deficiency of the proton coupled folate transporter, associated with systemic as well as cerebral folate deficiency, and deficiency of the folate receptor alpha, leading to an isolated cerebral folate deficiency associated with intractable seizures, developmental delay and/or regression, progressive ataxia and choreoathetoid movement disorders. Inborn errors of folate metabolism include deficiencies of the enzymes methylenetetrahydrofolate reductase, dihydrofolate reductase and 5,10-methenyltetrahydrofolate synthetase. Cerebral folate deficiency is potentially a treatable condition and so prompt recognition of these inborn errors and initiation of appropriate therapy is of paramount importance. Secondary cerebral folate deficiency may be observed in other inherited metabolic diseases, including disorders of the mitochondrial oxidative phosphorylation system, serine deficiency, and pyridoxine dependent epilepsy. Other secondary causes of cerebral folate deficiency include the effects of drugs, immune response activation, toxic insults and oxidative stress. This review describes the absorption, transport and metabolism of folate within the body; analytical methods to measure folate species in blood, plasma and CSF; inherited and acquired causes of cerebral folate deficiency; and possible treatment options in those patients found to have cerebral folate deficiency. This article is protected by copyright. All rights reserved

Effect of algal fibre supplementation (Eucheuma cottonii) on intestinal absorption of glucose and insulin response in the pig

International audienc

Neonatal pig enterocytes develop the capacity to oxidize long chain fatty acids

International audienc

Butyrate and glutamine metabolism in colonocytes: role of the intestinal microflora

International audienc