Venous leg symptoms in patients with migraine: a potential clue on the pathophysiology of migraine (Vein-Migraine study)

European-Society-of-Cardiology (ESC) Congress / Session on New Insights into Cardiology -- AUG 27-30, 2021 -- ELECTR NETWORK[Abstract Not Available]European Soc Cardio

Venous leg symptoms in migraineurs: a potential clue on the pathophysiology of migraine

BACKGROUND: Migraine is a neurovascular disorder which cerebral venous congestion might have role in pathogenesis. The objective was to assess the association between venous disease and migraine by using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) questionnaire in migraineurs and non-migraineurs. METHODS: The study was designed as a non-randomized, prospective cohort study and consisted of patients diagnosed with migraine and age-, sex- matched healthy subjects without migraine. All participants were examined for the presence of chronic venous disease (CVD). VEINES-Sym questionnaire was applied to assess venous symptoms. The Migraine Disability Assessment (MIDAS) questionnaire was used to assess the severity of disease in migraineurs. RESULTS: Participants were classified into two groups as migraine-positive group (N.=130) and migraine-negative group (N.=130). Migraine patients and control group were comparable in terms of clinical status and demographic parameters. Total VEINES-Sym score was lower in patients with migraine compared to control group (34.4 +/- 8.7, 37.6 +/- 8.12, P=0.003, respectively). Additionally, there was a significant negative correlation between VEINES-Sym score and total MIDAS disability score (r=-0.33, P<0.001) and MIDAS severity levels (little or no, mild, moderate, severe) (r=-0.266, P=0.003) of the migraineurs. Logistic regression analysis revealed that VEINES-Sym score is an independent and statistically significant associate of migraine (OR=0.95, 95% CI:0.92-0.98, P=0.001). CONCLUSIONS: We have documented an independent association between migraine and VEINES-Sym score indicating possible pathophysiological link between migraine and CVD. Further studies are warranted to figure out the pathophysiological associations between migraine and venous vascular pathology and peripheral varicose vein

Infectious agents, protein electrophoresis and immunoglobulin levels in patients with coronary artery ectasia

European-Society-of-Cardiology (ESC) Congress / Session on New Insights into Cardiology -- AUG 27-30, 2021 -- ELECTR NETWORK[Abstract Not Available]European Soc Cardio

Venous leg symptoms in patients with migraine: a potential clue on the pathophysiology of migraine (Vein-Migraine study)

Abstract Background Chronic venous disorders (CVD) that conventionally refers to disease of lower and upper extremity venous system encompass a large spectrum of abnormalities in the venous system. Recently, various venous disorders such as hemorrhoids, varicocele and lower extremity varicose veins have been gathered under the term of dilating venous disease (DVeD). So, vascular wall pathology itself has been supposed to be the underlying mechanism of DVeD in different vascular systems. Migraine is a neurovascular disorder which cerebral venous congestion might have role in pathogenesis. Both vascular and neurogenic theories have been postulated for the pathophysiology of migraine. We hypothesized that pathophysiology of migraine might related with DVeD due to vascular theory. Purpose The objective was to assess the association between venous disease and migraine by using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) questionnaire in migraineurs and non-migraineurs. Methods The study was designed as a non-randomized, prospective cohort study and consisted of patients diagnosed with migraine. The control group included age- and sex-matched healthy subjects. All participants were examined for the presence of CVD. Presence of lower extremity venous system disease and subsequent classification has been assessed and categorized according to clinical component of clinical, etiological, anatomical and pathological (CEAP) classification. VEINES-Sym questionnaire was applied to assess venous symptoms. The Migraine Disability Assessment (MIDAS) questionnaire was used to assess the severity of disease in migraineurs. Results Participants were classified into two groups as migraine (+) group (n=130) and migraine (−) group (n=130) (Figure 1). Migraine patients and control group were comparable in terms of clinical status and demographic parameters. The mean score of night cramps, burnings, itching, tingling and throbbing were found to be lower in migraineurs than those of non-migraineurs. In addition, the presence of venous symptoms, aching legs, night cramps, heat/burning sensation, throbbing and tingling were found to be significantly higher in patients with migraine compared with those without migraine (Figure 2). Also, total VEINES-Sym score was lower in patients with migraine compared to control group (34.4±8.7, 37.6±8.12, p=0.003, respectively). Additionally, there was a significant negative correlation between VEINES-Sym score and total MIDAS disability score (r=−0.33, p&amp;lt;0.001) and MIDAS severity levels (r=−0.266, p=0.003) of the migraineurs. Logistic regression analysis revealed that VEINES-Sym score is an independent and statistically significant associate of migraine (OR: 0.95, 95% CI: 0.92–0.98, p=0.001). Conclusions We have documented an independent association between migraine and VEINES-Sym score indicating possible pathophysiological link between migraine and CVD. Funding Acknowledgement Type of funding sources: None. </jats:sec

Infectious agents, protein electrophoresis and immunoglobulin levels in patients with coronary artery ectasia

Abstract Background Even the mechanism of coronary artery ectasia (CAE) shares the common pathophysiologic steps and risk factors with atherosclerosis which led to assume that CAE is a variant of atherosclerosis, there are certain discrepancies or aspects incompatible of atherosclerosis. Purpose We hypothesized that pathophysiology of CAE might differ from that of atherosclerosis in terms of inflammatory parameters, infectious agents. Therefore, we assessed and compared the levels of IgG antibody against Chlamydia pneumonia, and Helicobacter Pylori, components of serum protein electrophoresis and plasma levels of total Ig G and Ig E. Materials and methods Seventy patients with coronary artery disease (CAD) and 30 patients with CAD coexisted with CAE comprised the study populations. Blood samples were allowed to clot at room temperature then centrifuged at 1500 rpm for 5 minutes then serum kept at deep freeze (−20°C) to be used for the measurement of IgG antibodies against C. pneumoniae and H. Pylori, total IgE, IgG levels and protein electrophoresis. Results There were not statistically significant differences between patients with and without CAE regarding the clinical and laboratory parameters except hemoglobin levels (Figure I). IgE, Alpha 2 macroglobulin, Beta-1 globulin levels were found to be higher in patients with CAE+CAD than those of CAD alone (Figure IIa). There was no statistically significant correlation between the Gensini score, and IgG antibody against H. Pylori (r=0.048, p=0.66) and C. Pneumoniae (r=−0.12, p=0.27) regarding the whole study population. Additionally, logistic regression analysis by including variables IgE, hemoglobin, Alpha 2 macroglobulin, beta-1 globulin, and gender, revealed that Ig E and alpha 2 macroglobulin were independently and positively associated with the presence of CAE (Figure IIb). Conclusion Independent association of serum IgE levels and alpha2 globulins with the presence of CAE underlines the divergent features of pathophysiology of CAE compared with atherosclerosis or CAD alone. Funding Acknowledgement Type of funding sources: None. Figure IFigure II </jats:sec