A Collaborative Approach To 21st Century Business Technology Education

This paper reports on the University of Wyoming’s Master of Science in e.Business degree Program and experience from the first two years of its operation. The Program was initiated in response to the chronic shortage of graduates with skills in both business and technology. The program is a rare cooperative effort between the College of Business and the Department of Computer Science in the College of Engineering. We discuss the basic structure of the Program in terms of its interdisciplinary nature, accelerated delivery, educational objectives, team-oriented approach, classroom environment, involvement of business community, and skill sets emphasized. The primary tracks of study and courses within each track are explained. Demographic data on admitted and enrolled students is also presented. Challenges and plans for the future of the Program are also discussed

Response modes and coordination in a traffic context, an experimental comparison of Chinese and German participants

This paper reports results of laboratory experiments about traffic behavior of participants with different cultural backgrounds. We conducted the minority game as an elementary traffic scenario in which human participants of a German and Chinese subject pool had to choose over 100 periods between a road A and a road B. In each period, the road which was chosen by the minority of players won, these participants got a payoff. The payoff in the majority group was 0. An important observation is that the number of road changes of a participant is negatively correlated with her cumulative payoff. The Chinese participants reacted differently to the payoffs of preceding periods than the German participants

The mechanisms of phenology: the patterns and processes of phenological shifts

Species across a wide range of taxa and habitats are shifting phenological events in response to climate change. While advances are common, shifts vary in magnitude and direction within and among species, and the basis for this variation is relatively unknown. We examine previously suggested patterns of variation in phenological shifts in order to understand the cue-response mechanisms that underlie phenological change. Here, we review what is known about the mechanistic basis for nine factors proposed to predict phenological change (latitude, elevation, habitat type, trophic level, migratory strategy, ecological specialization, species\u27 seasonality, thermoregulatory mode, and generation time). We find that many studies either do not identify a specific underlying mechanism or do not evaluate alternative mechanistic hypotheses, limiting the ability of scientists to predict future responses to global change with accuracy. We present a conceptual framework that emphasizes a critical distinction between environmental (cue-driven) and organismal (response-driven) mechanisms causing variation in phenological shifts and discuss how this distinction can reduce confusion in the field and improve predictions of future phenological change

A simple stochastic cellular automaton for synchronized traffic flow

We present a very simple stochastic traffic cellular automaton (CA) model to reproduce synchronized traffic. This model aims to be nearly as simple as the well-known Nagel–Schreckenberg model, but to overcome to shortcomings of the latter: The Nagel–Schreckenberg model (NaSch) and its variants achieve collision-free driving by explicitly allowing for unlimited braking capabilities. However, it is rather natural to view the collision-free traffic flow as a consequence of moderate driving instead of infinite braking capabilities. Therefore, our new CA model limits the vehicles’ acceleration and deceleration rates to realistic values. Moreover, our model is able to reproduce several important features of synchronized traffic flow. Earlier models achieve identical goals only by using relatively complicated rules of motion. Our model, however, introduces slight modifications of the easily comprehensible NaSch. These modifications lead to very stable states where all vehicles tend to synchronize their speed. Even though, or perhaps precisely because, the states of synchronized flow are stable in our model, it allows to study several features of this traffic phase in great detail

A Geochemical Record of Late- Holocene Hurricane Events From the Florida Everglades

A 5.25- m sediment core SRM- 1 and 45 surface samples from mangrove forests at the Shark River Estuary in the Everglades National Park, Florida, were examined by using X- ray fluorescence and carbon isotopic analyses to study the history of intense hurricane landfall during the Late- Holocene. Significance testing of the surface samples in relation to storm deposits from Hurricane Wilma suggests that elemental concentration of Sr and Cl and the ratio of Cl/Br are the most sensitive indicators for major hurricane events in our study area. The geochemical data sets of core SRM- 1 identified five active periods of intense hurricane activities during the last 3,500 years at ~3,400- 3,000, ~2,200- 1,500, ~1,000- 800, ~600- 300, and ~150 calibrated years before present to present. This is the longest paleohurricane record to date from South Florida. Our results are consistent with the view that intense hurricane activities in South Florida were modulated by Intertropical Convergence Zone (ITCZ) movements, El Niño/Southern Oscillation (ENSO) activities, and North Atlantic Oscillation (NAO) strength. This study contributes to the methodological advancement in paleotempestological studies by demonstrating that geochemical signals, particularly signals of saltwater intrusions, can be preserved in the sediment profiles on millennial time- scale and measured by X- ray fluorescence techniques, thereby enabling more storm records to be produced from otherwise suboptimal sand- limited coastal systems such as the Florida Everglades. More work needs to be done to explore the use of geochemical and stable isotopic analyses in detecting storm signals from sand- limited coastal environments.Plain Language SummaryThis study uses geochemical analyses to detect intense hurricanes that made landfall near the southwest coast of the Florida Everglades from sediment profiles. The geochemical data sets identified five active periods of intense hurricane activities during the last 3,500 years at ~3,400- 3,000, ~2,200- 1,500, ~1,000- 800, ~600- 300, and ~150 years ago. Results from this study agree with previous studies that intense hurricane activities in the western Atlantic Basin were controlled by the position of ITCZ, ENSO activities, and NAO strength.Key PointsThis study demonstrates the use of XRF analysis in detecting major hurricane events in sand- limited coastal systemsFive active hurricane periods were identified at ~3,400- 3,000, ~2,200- 1,500, ~1,000- 800, ~600- 300, and ~150 cal yr BP to presentThis study suggests that intense hurricane activities in the western Atlantic Basin were modulated by ITCZ, ENSO, and NAO activitiesPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156482/2/wrcr24787_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156482/1/wrcr24787.pd

Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space

Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202

Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space

Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202

Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs

Rationale: Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy.Methods: We analyzed microRNA expression patterns from lung metastasis samples of patients with ≤5 initial metastases resected with curative intent.Results: Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset.Conclusion: Oligo- and poly- metastasis are distinct entities at the clinical and molecular level.</p

Moderators, Mediators, and Other Predictors of Risperidone Response in Children with Autistic Disorder and Irritability

Objective/Background: The National Institute of Mental Health (NIMH) Research Units on Pediatric Psychopharmacology (RUPP) Autism Network found an effect size of d = 1.2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritabilityin autistic disorder. This paper explores moderators and mediators of this effect. Method: Intention-to-treat (ITT) analyses were conducted with suspected moderators and mediators entered into the regression equations. MacArthur Foundation Network subgroup guidelines were followed in the evaluation of the results. Results: Only baseline severity moderated treatment response: Higher severity showed greater improvement for risperidone but not for placebo. Weight gain mediated treatment response negatively: Those who gained more weight improved less with risperidone and more with placebo. Compliance correlated with outcome for risperidone but not placebo. Higher dose correlated with worse outcome for placebo, but not risperidone. Of nonspecific predictors, parent education, family income, and low baseline prolactin positively predicted outcome; anxiety, bipolar symptoms, oppositional-defiant symptoms, stereotypy, and hyperactivity negatively predicted outcome. Risperidone moderated the effect of change in 5'-nucleotidase, a marker of zinc status, for which decrease was associated with improvement only with risperidone, not with placebo. Conclusion: The benefit–risk ratio of risperidone is better with greater symptom severity. Risperidone can be individually titrated to optimal dosage for excellent response in the majority of children. Weight gain is not necessary for risperidone benefit and may even detract from it. Socioeconomic advantage, low prolactin, and absence of co-morbid problems non-specifically predict better outcome. Mineral interactions with risperidone deserve further study

Mycobacterium abscessus Glycopeptidolipid Prevents Respiratory Epithelial TLR2 Signaling as Measured by HβD2 Gene Expression and IL-8 Release

Mycobacterium abscessus has emerged as an important cause of lung infection, particularly in patients with bronchiectasis. Innate immune responses must be highly effective at preventing infection with M. abscessus because it is a ubiquitous environmental saprophyte and normal hosts are not commonly infected. M. abscessus exists as either a glycopeptidolipid (GPL) expressing variant (smooth phenotype) in which GPL masks underlying bioactive cell wall lipids, or as a variant lacking GPL which is immunostimulatory and invasive in macrophage infection models. Respiratory epithelium has been increasingly recognized as playing an important role in the innate immune response to pulmonary pathogens. Respiratory epithelial cells express toll-like receptors (TLRs) which mediate the innate immune response to pulmonary pathogens. Both interleukin-8 (IL-8) and human β-defensin 2 (HβD2) are expressed by respiratory epithelial cells in response to toll-like receptor 2 (TLR2) receptor stimulation. In this study, we demonstrate that respiratory epithelial cells respond to M. abscessus variants lacking GPL with expression of IL-8 and HβD2. Furthermore, we demonstrate that this interaction is mediated through TLR2. Conversely, M. abscessus expressing GPL does not stimulate expression of IL-8 or HβD2 by respiratory epithelial cells which is consistent with “masking” of underlying bioactive cell wall lipids by GPL. Because GPL-expressing smooth variants are the predominant phenotype existing in the environment, this provides an explanation whereby initial M. abscessus colonization of abnormal lung airways escapes detection by the innate immune system