Ultra-rapid and relative humidity independent drying of nanochannels

We observed that water-filled nanochannels dried up to 1000 times faster than predicted by vapor diffusional drying. Here we show that this ultra-rapid water transport is caused by very sharp channel corners siphoning (wicking) the water to the channel exit before it evaporates. Evidence is also provided that these sharp corners make the drying process independent of the relative humidity (RH) of the environment up to an RH of more than 0.9. To our knowledge this is the first time that nanochannel drying has been observed, and both the acceleration of drying and the independence of RH are highly surprising

Perancangan Model Integrasi Manajemen Kebijakan Outsourcing Dalam Perspektif Hubungan Industrial

. This research objective is to design an outsourcing policy management integration model in industrial relation perspective in order to harmonize social, cultural, economic and legal aspects. The model is expected to improve welfare for workers, profit for industrial development, and provide benefit for the government.This research was initiated by field observation to analyze empirical condition on current outsourcing practices from the view of industries, government, and the workforce themselves along with their labor union. The result of problem identification was then analyzed to obtain outsourcing policy management integration model in order to build harmonious industrial relation. The method used was Soft System Methodology (SSM). Data were collected through FGD, IDI, and expert survey. Technique analysis was conducted through analysis CATWOE (Customer, Actor, Transformation, World-view, Owner, Environment constraint ), Analytical Network Process (ANP), Strategic Assumption Surfacing and Testing (SAST), through SSM Learning Models aiming to design Purposeful Activity Models (PAM). The Integration Management of Outsourcing Policy Model to perfom comprehensive management outsourcing system involving stakeholders in planning, supervision, guidance and enforcement to minimize conflict. The implication of modeling result is strong industrial relation trilogy; namely welfare for workers, security and sustainability for companies, conducive climate and benefits for the government

Pengaruh Aspek Pengelolaan Sumber Daya Manusia Terhadap Peningkatan Kinerja Organisasi Di Industri Otomotif Di Indonesia

Di Indonesia industri otomotif merupakan salah satu industri yang menyumbangkan pajak terbesar bagi pemerintah Indonesia. Saat ini industri otomotif Indonesia berkembang sangat cepat dan signifikan, dan dalam beberapa tahun ke depan diprediksikan akan menjadi yang terbesar di Asia Tenggara, menggeser posisi Thailand yang selama ini menjadi pemimpin pasar. Meskipun industri otomotif ini demikian pesat perkembangannya dan banyak menarik investor asing, sayangnya belum banyak penelitian yang mengkaji faktor-faktor apa saja yang menjadi kunci sukses industri ini di Indonesia. Mengingat bahwa industri ini merupakan industri yang bersifat technology-driven, dengan sistem produksi yang telah berkelas dunia dan infrastuktur manajemen lainnya yang saling mendukung, perlu dikaji selain faktor sistem produksi, faktor apa lagi yang dapat mempengaruhi kinerja organisasi pada industri ini. Dengan mempertimbangkan bahwa kehebatan suatu sistem produksi tidak dapat dilepaskan dari sumber daya manusia yang menciptakan, mengatur, menjalankan dan mengontrol sistem tersebut, maka tujuan utama dari penelitian ini adalah untuk mengkaji pengaruh aspek pengelolaan sumber daya manusia terhadap peningkatan kinerja organisasi di industri otomotif di Indonesia. Penelitian dilakukan pada dua Perusahaan otomotif milik Jepang di Indonesia, dan hasil penelitian menunjukkan bahwa aspek pengelolaan sumber daya manusia terbukti berpengaruh positif secara langsung dan signifikan terhadap kinerja organisasi di industri otomotif di Indonesia

Large scale patterning of hydrogel microarrays using capillary pinning

Capillary barriers provide a simple and elegant means for autonomous fluid-flow control in microfluidic systems. In this work, we report on the fabrication of periodic hydrogel microarrays in closed microfluidic systems using non-fluorescent capillary barriers. This design strategy enables the fabrication of picoliter-volume patterns of photopolymerized and thermo-gelling hydrogels without any defects and distortions

PHARAO Laser Source Flight Model: Design and Performances

In this paper, we describe the design and the main performances of the PHARAO laser source flight model. PHARAO is a laser cooled cesium clock specially designed for operation in space and the laser source is one of the main sub-systems. The flight model presented in this work is the first remote-controlled laser system designed for spaceborne cold atom manipulation. The main challenges arise from mechanical compatibility with space constraints, which impose a high level of compactness, a low electric power consumption, a wide range of operating temperature and a vacuum environment. We describe the main functions of the laser source and give an overview of the main technologies developed for this instrument. We present some results of the qualification process. The characteristics of the laser source flight model, and their impact on the clock performances, have been verified in operational conditions.Comment: Accepted for publication in Review of Scientific Instrument

Proton acceleration by irradiation of isolated spheres with an intense laser pulse

We report on experiments irradiating isolated plastic spheres with a peak laser intensity of 2-3 x 10(20) W cm(-2). With a laser focal spot size of 10 mu m full width half maximum (FWHM) the sphere diameter was varied between 520 nm and 19.3 mu m. Maximum proton energies of similar to 25 MeV are achieved for targets matching the focal spot size of 10 mu m in diameter or being slightly smaller. For smaller spheres the kinetic energy distributions of protons become nonmonotonic, indicating a change in the accelerating mechanism from ambipolar expansion towards a regime dominated by effects caused by Coulomb repulsion of ions. The energy conversion efficiency from laser energy to proton kinetic energy is optimized when the target diameter matches the laser focal spot size with efficiencies reaching the percent level. The change of proton acceleration efficiency with target size can be attributed to the reduced cross-sectional overlap of subfocus targets with the laser. Reported experimental observations are in line with 3D3V particle in cell simulations. They make use of well-defined targets and point out pathways for future applications and experiments.DFG via the Cluster of Excellence Munich-Centre for Advanced Photonics (MAP) Transregio SFB TR18NNSA DE-NA0002008Super-MUC pr48meIvo CermakCGC Instruments in design and realization of the Paul trap systemIMPRS-APSLMUexcellent Junior Research FundDAAD|ToIFEEuropean Union's Horizon research and innovation programme 633053Physic

Selenoprotein dio2 is a regulator of mitochondrial function, morphology and uprmt in human cardiomyocytes

Members of the fetal-gene-program may act as regulatory components to impede deleterious events occurring with cardiac remodeling, and constitute potential novel therapeutic heart failure (HF) targets. Mitochondrial energy derangements occur both during early fetal development and in patients with HF. Here we aim to elucidate the role of DIO2, a member of the fetal-gene-program, in pluripotent stem cell (PSC)-derived human cardiomyocytes and on mitochondrial dynamics and energetics, specifically. RNA sequencing and pathway enrichment analysis was performed on mouse cardiac tissue at different time points during development, adult age, and ischemia-induced HF. To determine the function of DIO2 in cardiomyocytes, a stable human hPSC-line with a DIO2 knockdown was made using a short harpin sequence. Firstly, we showed the selenoprotein, type II deiodinase (DIO2): the enzyme responsible for the tissue-specific conversion of inactive (T4) into active thyroid hormone (T3), to be a member of the fetal-gene-program. Secondly, silencing DIO2 resulted in an increased reactive oxygen species, impaired activation of the mitochondrial unfolded protein response, severely impaired mitochondrial respiration and reduced cellular viability. Microscopical 3D reconstruction of the mitochondrial network displayed substantial mitochondrial fragmentation. Summarizing, we identified DIO2 to be a member of the fetal-gene-program and as a key regulator of mitochondrial performance in human cardiomyocytes. Our results suggest a key position of human DIO2 as a regulator of mitochondrial function in human cardiomyocytes

ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

ATPase inhibitory factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial dysfunction and pathological cardiomyocyte hypertrophy in the context of heart failure (HF). Methods and results: Cardiac expression of IF1 was increased in mice and in humans with HF, downstream of neurohumoral signaling pathways and in patterns that resembled the fetal-like gene program. Adenoviral expression of wild-type IF1 in primary cardiomyocytes resulted in pathological hypertrophy and metabolic remodeling as evidenced by enhanced mitochondrial oxidative stress, reduced mitochondrial respiratory capacity, and the augmentation of extramitochondrial glycolysis. Similar perturbations were observed with an IF1 mutant incapable of binding to ATP synthase (E55A mutation), an indication that these effects occurred independent of binding to ATP synthase. Instead, IF1 promoted mitochondrial fragmentation and compromised mitochondrial Ca2+ handling, which resulted in sarcoplasmic reticulum Ca2+ overloading. The effects of IF1 on Ca2+ handling were associated with the cytosolic activation of calcium-calmodulin kinase II (CaMKII) and inhibition of CaMKII or co-expression of catalytically dead CaMKIIδC was sufficient to prevent IF1 induced pathological hypertrophy. Conclusions: IF1 represents a novel member of the fetal-like gene program that contributes to mitochondrial dysfunction and pathological cardiac remodeling in HF. Furthermore, we present evidence for a novel, ATP-synthase-independent, role for IF1 in mitochondrial Ca2+ handling and mitochondrial-to-nuclear crosstalk involving CaMKII