Symbolic Fractions Elicit an Analog Magnitude Representation in School-age Children

A fundamental question about fractions is whether they are grounded in an abstract non-symbolic magnitude code, similar to those postulated for whole numbers. Mounting evidence suggests that symbolic fractions could be grounded in mechanisms for perceiving non-symbolic ratio magnitudes. However, systematic examination of such mechanisms in children has been lacking. We asked second and fifth grade children (prior to and after formal instructions with fractions, respectively) to compare pairs of symbolic fractions, non-symbolic ratios and mixed symbolic/non-symbolic pairs. This paradigm allowed us to test three key questions: 1) whether children show an analog magnitude code for rational numbers, 2) whether that code is compatible with mental representations of symbolic fractions, and 3) how formal education with fractions affects the symbolic-non-symbolic relation. We examined distance effects as a marker of analog ratio magnitude processing and notation effects as a marker of converting across numerical codes. Second and fifth grade children’s response times and error rates showed classic distance and notation effects. Non-symbolic ratios were processed most efficiently, with mixed and symbolic notations being relatively slower. Children with more formal instruction in symbolic fractions had a significant advantage in comparing symbolic fractions, but a smaller advantage for non-symbolic ratio stimuli. Supplemental analyses showed that second graders relied on numerator distance more than holistic distance, and fifth graders relied on holistic fraction magnitude distance more than numerator distance. These results suggest that children have a non-symbolic ratio magnitude code, and that symbolic fractions can be translated into that magnitude code.</p

Flavoprotein oxidases:classification and applications

<p>This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically interesting enzymes. Applications range from their use as biocatalysts for the synthesis of pharmaceutical compounds to the integration in biosensors. Through the recent developments in genome sequencing, the number of newly discovered oxidases is steadily growing. Recent progress in the field of flavoprotein oxidase discovery and the obtained biochemical knowledge on these enzymes are reviewed. Except for a structure-based classification of known flavoprotein oxidases, also their potential in recent biotechnological applications is discussed.</p>