ANÁLISIS FLORÍSTICO DE LA REGENERACIÓN NATURAL DEL BOSQUE SEMIDECIDUO MESÓFILO DE LA ESTACIÓN EXPERIMENTAL AGROFORESTAL DE GUISA (Original)

The work was carried out in the Forest of the Agro-forestry Experimental Station Guisa to analyze the floristic structure plots of 100 m2 and 4 m2 nested were randomly established, the normal diameter and height of the trees were taken, as well as the height of the plants smaller than 4 meters in height and ≤ 5 cm in diameter. Species were identified; the biological spectrum was made to assess floristic diversity, and the presence histogram to observe the heterogeneity of the species. The families Sapindaceae, Rubiaceae and Fabaceae were the most rich in species. The most constants and better distributed species under the forest roof were Eugenia buxifolia, Nectandra coriacea and Sideroxylon salicifolium, forming a BDP which allowed to the species respond to the stress of the place in an efficient way and for this they establish the physiognomy of the regenerant stratus.El trabajo se realizó en el Bosque de la Estación Experimental Agroforestal Guisa para analizar la estructura florística. Se establecieron aleatoriamente parcelas de 100 m2 y de 4 m2 anidadas, se tomó el diámetro normal y altura de los árboles, así como la altura de las plantas menores de 4 m de altura y ≤ 5 cm de diámetro. Se identificaron las especies, se confeccionó el espectro biológico para valorar la diversidad florística, y el histograma de presencia para observar la heterogeneidad de la misma. Las familias Sapindaceae, Rubiaceae y Fabaceae resultaron las de mayor riqueza de especies. Las especies más abundantes, constantes y mejor distribuidas bajo el dosel del bosque fueron Eugenia buxifolia, Nectandra coriacea y Sideroxylon salicifolium, formando banco de plántulas que les permite responder adaptativamente al estrés del sitio de forma eficiente y por tanto establecen la fisionomía del estrato regenerante

Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study

Background: Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods: This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results: A total of 711 patients [67% male, median age (range) 67 (20-89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P =. 001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P =. 693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P =. 001), lower time from booster (P =. 043) and past breakthrough SARS-CoV-2 infection (P <. 001). Conclusions: In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infectionThe present project has been supported by Fresenius Medical Care, Diaverum, Vifor Pharma, Vircell, Fundación Renal Iñigo Álvarez de Toledo and ISCIII FEDER funds RICORS2040 (RD21/0005

Valoración clínica y angiográfica de la reestenosis del stent coronario convencional

Introduction: Ischemic heart disease is the leading cause of death in Cuba. Coronary angioplasty with stenting is an excellent treatment option, but restenosis overshadows its prognosis and is more common with the use of bare metal stents.Objective: To characterize restenosis after coronary bare-metal stent from the clinical and angiographic points of view.Method: A descriptive cross-sectional study was conducted in 59 patients with a diagnosis of restenosis after coronary bare-metal stent confirmed by angiography in the Interventional Cardiology Unit of Cardiocentro Ernesto Che Guevara of Villa Clara, Cuba, from February 2010 to April 2012. The variables analyzed were age, sex, coronary risk factors, previous history of angina or heart attack, vessel involved, type of restenosis and treated lesion, vessel diameter and lesion length.Results: Predominance of male patients (76.27 %), aged 60-69 years (40.66 %). The most common risk factors were hypertension (76.27 %), smoking (37.28 %) and type II diabetes mellitus (33.89 %). The most affected vessel was the left anterior descending (28.81 %), arterial diameters were predominantly ≤ 2.5 mm (54.2%) and lesion length > 20 mm (65, 97). Type B injuries (52.5) and focal restenosis (57.62 %) were more frequent.Conclusions: Patients with restenosis were predominantly male, between 60-69 years old, with a history of hypertension, smoking and diabetes mellitus type II. Left anterior descending disease, diameter ≤ 2.5 mm, lesion length > 20 mm, type B coronary lesion and focal restenosis were more frequent.Introducción: La cardiopatía isquémica es la principal causa de muerte en Cuba. La angioplastia coronaria con stent es una excelente opción terapéutica, pero la reestenosis ensombrece su pronóstico y es mucho más frecuente con el uso de stents convencionales.Objetivo: Caracterizar clínica y angiográficamente la reestenosis del stent coronario convencional.Método: Se realizó un estudio descriptivo y transversal en los 59 pacientes con diagnóstico de reestenosis del stent coronario convencional confirmado por angiografía en la Unidad de Cardiología Intervencionista del Cardiocentro “Ernesto Che Guevara” de Villa Clara, Cuba, durante el período febrero 2010 – abril 2012. Las variables analizadas fueron edad, sexo, factores de riesgo coronario, historia previa de angina o infarto, vaso afectado, tipo de reestenosis y de lesión tratada, diámetro del vaso y longitud de la lesión.Resultados: Predominaron los pacientes del sexo masculino (76,3 %), con edades comprendidas entre 60-69 años (40,7 %). Los factores de riesgo más frecuentes fueron la hipertensión arterial (76,3 %), el hábito de fumar (37,3 %) y la diabetes mellitus tipo II (33,9 %). El vaso más afectado fue la descendente anterior (59,3 %), los diámetros arteriales eran predominantemente ≤ 2,5 mm (54,2 %) y la longitud de las lesiones > 20 mm (66,1 %). Las lesiones tipo B (52,5 %) y la reestenosis focal (57,6 %) fueron más frecuentes.Conclusiones: Los pacientes con reestenosis eran predominantemente hombres, entre 60-69 años de edad, con antecedentes de hipertensión arterial, tabaquismo y diabetes mellitus tipo II. La enfermedad de la descendente anterior, el diámetro del vaso ≤ 2,5 mm, la longitud de las lesiones > 20 mm, la lesión coronaria tipo B y la reestenosis focal fueron más frecuentes

COVAD survey 2 long-term outcomes: unmet need and protocol

Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups

COVAD survey 2 long-term outcomes: unmet need and protocol

Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups

Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study

Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb-June 2022. We collected data on demographics, comorbidities, IIM/SAID details, COVID-19 history, and vaccination details. Delayed-onset (> 7 day) AEs were analyzed using regression models. A total of 15165 respondents undertook the survey, of whom 8759 responses from vaccinated individuals [median age 46 (35-58) years, 74.4% females, 45.4% Caucasians] were analyzed. Of these, 1390 (15.9%) had IIMs, 50.6% other SAIDs, and 33.5% HCs. Among IIMs, 16.3% and 10.2% patients reported minor and major AEs, respectively, and 0.72% (n = 10) required hospitalization. Notably patients with IIMs experienced fewer minor AEs than other SAIDs, though rashes were expectedly more than HCs [OR 4.0; 95% CI 2.2-7.0, p < 0.001]. IIM patients with active disease, overlap myositis, autoimmune comorbidities, and ChadOx1 nCOV-19 (Oxford/AstraZeneca) recipients reported AEs more often, while those with inclusion body myositis, and BNT162b2 (Pfizer) recipients reported fewer AEs. Vaccination is reassuringly safe in individuals with IIMs, with AEs, hospitalizations comparable to SAIDs, and largely limited to those with autoimmune multimorbidity and active disease. These observations may inform guidelines to identify high-risk patients warranting close monitoring in the post-vaccination period