Evaluation of Clinical Efficacy of Biodegradable Chip Containing Salvadora persica Extract in Chitosan Base as an Adjunct to Scaling and Root Planning in the Management of Periodontitis

Objective: The objectives of this study were to develop two biodegradable periodontal chips containing Salvadora persica or Benzyl isothiocyanate (BITC) extract and evaluate its clinical effectiveness in managing periodontitis. Methods: Chips were formulated from Salvadora persica, Benzyl isothiocyanate (BITC) and chitosan; twelve patients with periodontal pockets measuring ≥5 mm participated in this study. Overall, 240 periodontal pockets were evaluated. All patients were treated with full mouth scaling and root planning (SRP) at baseline. Periodontal pockets were divided into four groups. One of which is the control group, while group two received plain chitosan chip. Group three received chips containing Salvadora persica extract, and group four received chips containing BITC. Plaque index (PI), bleeding on probing (BOP), periodontal probing pocket (PPD) depth, and clinical attachment levels (CAL) using acrylic stents were recorded at days 0 and 60 only. Results: Data were statistically analysed; Chi-square t-test and an ANOVA were used. Results showed significant improvement in plaque index, bleeding on probing, and reduction in periodontal pocket depth in all four groups (p<0.05). The gain in clinical attachment level was significantly higher (p<0.005) among the group receiving Salvadora persica chips compared to the control and other chip-treated groups. Conclusion: Periodontal chips containing S. persica can be used as adjuncts to treat patients with periodontitis. Keywords: Chitosan; Periodontal chip; Miswak extract; Benzyl isothiocyanate; Periodontitis

Formulation and Evaluation of a New Biodegradable Periodontal Chip Containing Thymoquinone in a Chitosan Base for the Management of Chronic Periodontitis

Objective. This study was performed to develop a biodegradable periodontal chip containing thymoquinone and to evaluate its effectiveness for managing chronic periodontitis. Methods. Chips were formulated from thymoquinone and chitosan. Twelve patients with periodontal pockets measuring ≥5 mm participated in this study. Overall, 180 periodontal pockets were evaluated. At day zero, all patients were treated with full-mouth scaling and root planning. Periodontal pockets were divided into three groups. Group one served as the control group, while group two received plain chitosan chips. Group three received chips containing thymoquinone. Plaque index, bleeding upon probing, periodontal probing pocket depths, and clinical attachment levels were recorded at days 0 and 60. Results. The statistical significance of differences was tested with a paired sample t-test, a Chi-squared test, and a one-way ANOVA. The results indicated significant improvement in plaque index and bleeding upon probing and a reduction in periodontal pockets from baseline in all four groups ( < 0.05). Gains in clinical attachment levels were significantly higher ( < 0.005) in the group receiving thymoquinone chips compared to other groups. Conclusion. Periodontal chips containing thymoquinone can be used as adjuncts for the treatment of patients with chronic periodontitis

Formulation and Evaluation of a New Biodegradable Periodontal Chip Containing Thymoquinone in a Chitosan Base for the Management of Chronic Periodontitis

Objective. This study was performed to develop a biodegradable periodontal chip containing thymoquinone and to evaluate its effectiveness for managing chronic periodontitis. Methods. Chips were formulated from thymoquinone and chitosan. Twelve patients with periodontal pockets measuring ≥5 mm participated in this study. Overall, 180 periodontal pockets were evaluated. At day zero, all patients were treated with full-mouth scaling and root planning. Periodontal pockets were divided into three groups. Group one served as the control group, while group two received plain chitosan chips. Group three received chips containing thymoquinone. Plaque index, bleeding upon probing, periodontal probing pocket depths, and clinical attachment levels were recorded at days 0 and 60. Results. The statistical significance of differences was tested with a paired sample t-test, a Chi-squared test, and a one-way ANOVA. The results indicated significant improvement in plaque index and bleeding upon probing and a reduction in periodontal pockets from baseline in all four groups (P<0.05). Gains in clinical attachment levels were significantly higher (P<0.005) in the group receiving thymoquinone chips compared to other groups. Conclusion. Periodontal chips containing thymoquinone can be used as adjuncts for the treatment of patients with chronic periodontitis