Quantum repeaters and computation by a single module

We present a protocol of remote nondestructive parity measurement (RNPM) on a pair of quantum memories. The protocol works as a single module for key operations such as entanglement generation, Bell measurement, parity check measurement, and an elementary gate for extending one-dimensional cluster states. The RNPM protocol is achieved by a simple combination of devices such as lasers, optical fibers, beam splitters, and photon detectors. Despite its simplicity, a quantum repeater composed of RNPM protocols is shown to have a communication time that scales sub-exponentially with the channel length, and it can be further equipped with entanglement distillation. With a reduction in the internal losses, the RNPM protocol can also be used for generating cluster states toward measurement-based quantum communication.Comment: 7 pages, 4 figure

Socio-environmental factors associated with diabetes mellitus among patients hospitalized with schizophrenia in Japan

Sado, J., Kitamura, T., Noma, N. et al. Socio-environmental factors associated with diabetes mellitus among patients hospitalized with schizophrenia in Japan. Environ Health Prev Med 21, 460–469 (2016). https://doi.org/10.1007/s12199-016-0550-

Effective Stress Analysis by Shear Strain Controllable Model and its Application to Centrifuge Shaking Model Test

Effective stress FEM which is able to control the growth of shear strains is proposed. Its validity is firstly confirmed through the simulation of undrained cyclic torsional shear tests. Then, it is applied to simulation of centrifuge shaking model tests; the experimental model consists of a caisson type quay wall and reclamation laid on the sand layer. Development of shear strain is shown to be controlled arbitrary keeping the excess porewater pressure generation unchanged through the simulation of undrained cyclic torsional shear test, which indicates that proposed model can be applicable to variety of soils with different density and fines contents. Displacement is shown to be controlled keeping excess porewater pressure generation constant in the centrifugal model, too, and good agreement is obtained between test and analysis by controlling the parameter for shear strain development

Drug-drug interactions

Several drugs are using to obtain a desired therapeutic objective or to treat coexisting diseases. The choice of drugs should be dependent on pharmacological characteristics. Interactions may be either pharmacokinetic or pharmacodynamic. In pharmacokinetic interaction, drugs may interact at any point during their absorption, distribution, metabolism, or excretion; the result may be an increase or decrease in the concentration of drug at the site of action. Metabolic enzyme, cytochrome P450, which metabolites any drugs is important in pharmacokinetic interaction. As characteristics change in their rates of disposition of using drug, the magnitude of an interaction that changes pharmacokinetic parameter is not always predictable but can be very significant. In pharmacodynamic interaction, drugs may interact at common receptor site or have additive or inhibitory effects due to actions at different sites in an organ. A drug interaction should be suspected danger when unexpected effects are observed. Careful drug histories are important, because patients may take over-the-counter drugs, may take drugs prescribed by another physician, or may take drugs prescribed for another patient. Care should be exercised when major changes are made in a drug regimen. Then, drugs that are not necessary should be discontinued. The major work of the medical staff of a hospital is to determine if an interaction has occurred and the magnitude of its effect. The interacting drugs should be used effectively with adjustment of dosage or other therapeutic modifications when an interaction is observed

Estimation of annual layer thickness from stratigraphical analysis of Dome Fuji deep ice core

Dating of ice cores is of important but is difficult for an ice core where there is low snow accumulation, and also for the deep part because seasonal chemical and isotopic signals are not easily preserved due to vapor migration after snow deposition and molecular diffusion in the deep part of ice sheet. In this paper, an attempt to reveal annual layer thickness is conducted on the basis of precise number density measurement of air bubbles and air hydrates. The annual layer thickness from air bubbles and hydrates agrees well with a calculated value within 10-15% at all depths of the 2500 m deep core. The obtained thickness in the interglacial period according to Eemian period in the Greenland ice core was half of the calculated value

Possible role of bradykinin on stimulus-secretion coupling in adrenal chromaffin cells

Nonapeptide bradykinin is known to be a central nervous system neurotrans-mitter and to play a role in regulation of neuronal function. However, few details are known of the function of its peptide on stimulus-secretion coupling in neuronal cells. In this article, the role of bradykinin on catecholamine biosynthesis, secretion and Ca2+movement in adrenal chromaffin cells as a model for catecholamine-containing neurons are examined. Bradykinin receptors are classified as B1 and B2 receptor subtypes. These receptors are present on the adrenal chromaffin cell membrane. Bradykinin increases the influx of Ca2+ and the turnover of phosphoinositide through the stimulation of bradykinin B2 receptor. The secretion of catecholamine from the cells is initiated by the raise of [Ca2+]i. An increase in [Ca2+]i and production of diacylglycerol stimulate the activation of calcium-dependent protein kinases. These kinases stimulate the activation of tyrosine hydroxylase, a rate-limiting enzyme in the biosynthesis of catecholamine. Otherwise, bradykinin increases Ca2+ efflux from the cells through the stimulation of the bradykinin-B2 receptor. This action may be explained by an extracellular Na+-dependent mechanism, probably through acceleration of Na+/Ca2+ exchange. It is interesting that bradykinin, which stimulates the biosynthesis and secretion of catecholamine in adrenal chromaffin cells, plays a role in the termination of calcium-signal transduction through the stimu-lation of Ca2+ efflux from the cells

Perception of leaning backward while standing and patellar movement

金沢大学医薬保健研究域保健学系[Purpose] The purpose of this study was to investigate the relationship between the patellar movement and the standing backward leaning perceptibility. [Subjects and Methods] Fourteen volunteers who were confirmed presence of upward patellar movement during backward leaning from the quiet standing posture participated in this study. The quiet standing position, the standing backward leaning position at patellar movement onset and standing position perceptibility were measured. The position of the center of pressure in the anteroposterior direction in standing is represented as the percentage distance from the hindmost point of the heel in relation to the foot length (%FL). [Results] The mean value of the center of pressure on anteroposterior direction positions in quiet standing was 43.2%FL. The patellar movement onset position was 35.1%FL. The individual mean value of standard deviations for the onset position was 2.5%FL. The absolute error at the onset position is specifically and significantly small. [Conclusion] For the subjects whose patellas move during backward leaning in this study, the standing position near the onset position was perceived accurately, probably by the substantial change in sensory information associated with the onset of patellar movement while backward leaning.出版社照会後に全文公

Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients

(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer

monosodium glutamate increases T1R3 expression

We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3 (T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed 10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance