3,710 research outputs found
Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the growing incidence of fibrotic diseases and extensive research efforts, there remains a lack of effective therapies that improve survival. The application of omics technologies has revolutionized our approach to identifying previously unknown therapeutic targets and potential disease biomarkers. The application of metabolomics, in particular, has improved our understanding of disease pathomechanisms and garnered a wave of scientific interest in the role of metabolism in the biology of myofibroblasts, the key effector cells of the fibrogenic response. Emerging evidence suggests that alterations in metabolism not only are a feature of but also may play an influential role in the pathogenesis of fibrosis, most notably in idiopathic pulmonary fibrosis (IPF), the most rapidly progressive and fatal of all fibrotic conditions. This review will detail the role of key metabolic pathways, their alterations in myofibroblasts, and the potential this new knowledge offers for the development of antifibrotic therapeutic strategies
Fourth Generation Pseudoscalar Quarkonium Production and Observability at Hadron Colliders
The pseudoscalar quarkonium state, eta_4 1^S_0, formed by the Standard Model
(SM) fourth generation quarks, is the best candidate among the fourth
generation quarkonia to be produced at the LHC and VLHC. The production of this
J^{PC} = 0^{-+} resonance is discussed and the background processes are studied
to obtain the integrated luminosity limits for the discovery, depending on its
mass.Comment: 13 pages, 4 figures, 5 table
Prospects for the Search for a Standard Model Higgs Boson in ATLAS using Vector Boson Fusion
The potential for the discovery of a Standard Model Higgs boson in the mass
range m_H < 2 m_Z in the vector boson fusion mode has been studied for the
ATLAS experiment at the LHC. The characteristic signatures of additional jets
in the forward regions of the detector and of low jet activity in the central
region allow for an efficient background rejection. Analyses for the H -> WW
and H -> tau tau decay modes have been performed using a realistic simulation
of the expected detector performance. The results obtained demonstrate the
large discovery potential in the H -> WW decay channel and the sensitivity to
Higgs boson decays into tau-pairs in the low-mass region around 120 GeV.Comment: 20 pages, 13 ps figures, uses EPJ style fil
Dimensionless Coupling of Bulk Scalars at the LHC
We identify the lowest-dimension interaction which is possible between
Standard Model brane fields and bulk scalars in 6 dimensions. The
lowest-dimension interaction is unique and involves a trilinear coupling
between the Standard Model Higgs and the bulk scalar. Because this interaction
has a dimensionless coupling, it depends only logarithmically on ultraviolet
mass scales and heavy physics need not decouple from it. We compute its
influence on Higgs physics at ATLAS and identify how large a coupling can be
detected at the LHC. Besides providing a potentially interesting signal in
Higgs searches, such couplings provide a major observational constraint on 6D
large-extra-dimensional models with scalars in the bulk.Comment: 20 page
Casimir Energies for 6D Supergravities Compactified on T_2/Z_N with Wilson Lines
We compute (as functions of the shape and Wilson-line moduli) the one-loop
Casimir energy induced by higher-dimensional supergravities compactified from
6D to 4D on 2-tori, and on some of their Z_N orbifolds. Detailed calculations
are given for a 6D scalar field having an arbitrary 6D mass m, and we show how
to extend these results to higher-spin fields for supersymmetric 6D theories.
Particular attention is paid to regularization issues and to the identification
of the divergences of the potential, as well as the dependence of the result on
m, including limits for which m^2 A> 1 where A is the volume of
the internal 2 dimensions. Our calculation extends those in the literature to
very general boundary conditions for fields about the various cycles of these
geometries. The results have potential applications towards Supersymmetric
Large Extra Dimensions (SLED) as a theory of the Dark Energy. First, they
provide an explicit calculation within which to follow the dependence of the
result on the mass of the bulk states which travel within the loop, and for
heavy masses these results bear out the more general analysis of the
UV-sensitivity obtained using heat-kernel methods. Second, because the
potentials we find describe the dynamics of the classical flat directions of
these compactifications, within SLED they would describe the present-day
dynamics of the Dark Energy.Comment: 40 pages, 7 figure
A search for heavy Kaluza-Klein electroweak gauge bosons at the LHC
The feasibility for the observation of a certain leptonic Kaluza-Klein (KK)
hard process in {\em pp} interactions at the LHC is presented. Within the
TeV extra dimensional theoretical framework with the focus on
the KK excitations of the Standard Model and gauge bosons, the
hard-process, , has
been used where is the initial state parton, the final state lepton and
is the KK excitation of the
boson. For this study the analytic form for the hard process cross
section has been independently calculated by the authors and has been
implemented using the {\sc Moses} framework. The Moses framework itself, that
has been written by the authors, was used as an external process within the
{\sc Pythia} Monte Carlo generator which provides the phase space generation
for the final state leptons and partons from the initial state hadrons, and the
simulation of initial and final state radiation and hadronization. A brief
discussion of the possibility for observing and identifying the unique
signature of the KK signal given the current LHC program is also presented.Comment: 16 pages 10 figures, MCnet number: MCnet/10/06, Accepted by JHE
Models of Little Higgs and Electroweak Precision Tests
The little Higgs idea is an alternative to supersymmetry as a solution to the
gauge hierarchy problem. In this note, I review various little Higgs models and
their phenomenology with emphases on the precision electroweak constraints in
these models.Comment: 16 pages; 4 figures; review submitted to Modern Physics Letter
MSLED, Neutrino Oscillations and the Cosmological Constant
We explore the implications for neutrino masses and mixings within the
minimal version of the supersymmetric large-extra-dimensions scenario (MSLED).
This model was proposed in {\tt hep-ph/0404135} to extract the phenomenological
implications of the promising recent attempt (in {\tt hep-th/0304256}) to
address the cosmological constant problem. Remarkably, we find that the
simplest couplings between brane and bulk fermions within this approach can
lead to a phenomenologically-viable pattern of neutrino masses and mixings that
is also consistent with the supernova bounds which are usually the bane of
extra-dimensional neutrino models. Under certain circumstances the MSLED
scenario can lead to a lepton mixing (PMNS) matrix close to the so-called
bi-maximal or the tri-bimaximal forms (which are known to provide a good
description of the neutrino oscillation data). We discuss the implications of
MSLED models for neutrino phenomenology.Comment: 38 pages, 1 figure; Reposted with a few additional reference
Little Hierarchy, Little Higgses, and a Little Symmetry
Little Higgs theories are an attempt to address the little hierarchy problem,
i.e., the tension between the naturalness of the electroweak scale and the
precision measurements showing no evidence for new physics up to 5-10 TeV. In
little Higgs theories, the Higgs mass-squareds are protected to the one-loop
order from the quadratic divergence. This allows the cutoff to be raised up to
\~10 TeV, beyond the scales probed by the precision data. However, strong
constraints can still arise from the contributions of the new TeV scale
particles and hence re-introduces the fine-tuning problem. In this paper we
show that a new symmetry, denoted as T-parity, under which all heavy gauge
bosons and scalar triplets are odd, can remove all the tree-level contributions
to the electroweak observables and therefore makes the little Higgs theories
completely natural. The T-parity can be manifestly implemented in a majority of
little Higgs models by following the most general construction of the low
energy effective theory a la Callan, Coleman, Wess and Zumino. In particular,
we discuss in detail how to implement the T-parity in the littlest Higgs model
based on SU(5)/SO(5). The symmetry breaking scale f can be even lower than 500
GeV if the contributions from the unknown UV physics at the cutoff are somewhat
small. The existence of -parity has drastic impacts on the phenomenology of
the little Higgs theories. The T-odd particles need to be pair-produced and
will cascade down to the lightest T-odd particle (LTP) which is stable. A
neutral LTP gives rise to missing energy signals at the colliders which can
mimic supersymmetry. It can also serve as a good dark matter candidate.Comment: 20 pages, 2 figures, RevTeX; v2: Yukawa sector in the SU(5)/SO(5)
model slightly modified. Also added comments on the Dirac mass term for the
fermionic doublet partner; v3: clarifying comments on the modified Yukawa
sector. version to appear on JHE
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