59 research outputs found

    Insights into Temporal Evolution of Induced Earthquakes in the Southern Delaware Basin Using Calibrated Relocations from the TXAR Catalog (2009-2016)

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    The Texas Seismological Network (TexNet) has enabled real-time monitoring of induced earthquakes since 2017. Before 2017, location uncertainties and temporal gaps in seismic data obscure correlations across Texas between seismicity and saltwater disposal or hydraulic fracturing. Depth biases also complicate linking anthropogenic stress changes to faults. We relocate 73 M 1.5+ earthquakes from the TXAR catalog (2009-2016) relative to the centroid of a calibrated core cluster consisting of 116 earthquakes from the TexNet catalog post-2020, in the southern Delaware basin south of the Grisham fault zone. Hypocentroidal decomposition relocation reduces spatial uncertainties of the TXAR events to <5 km and provides updated depths. The core cluster has uncertainties less than <300 m and depth constrained from near-source stations and S-P differential times. The majority of relocated TXAR events indicate the triggering of northwest-trending faults at a mean depth of 1 km below sea level, suggesting a causal connection with shallow saltwater disposal and consistency with post-2017 seismicity. Spatiotemporal patterns of pre-2017 seismicity and saltwater disposal highlight initial triggering via pore-pressure stress perturbations from nearby low-volume injections and later from southeastward pressure diffusion along permeable anisotropic conduits and fracture zones. The comparison between pre- and post-2017 seismicity indicates shallow fault reactivation through similar triggering mechanisms since 2009

    Seismicity in the western coast of the South Caspian Basin and the Talesh Mountains

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    We have studied the seismicity of the western margin of the South Caspian Basin (SCB) and the neighbouring Talesh fold and thrust belt. We have used the hypocentroidal decomposition multiple-event location technique to obtain accurate location of events recorded during 2 yr of observation. Data from a temporary seismic network in northwest Iran and other national and regional networks were combined to make an accurate assessment of seismicity in the region. Significant offshore seismicity is observed in a 50-km wide margin of the SCB. East of the Talesh Fault along the Caspian coastline, the depth of seismicity varies from 20 to 47 km. This pattern extends inland about 20–25 km west of the North Talesh Fault. This pattern of seismicity indicates that the basement slab of the South Caspian is undergoing intense seismic deformation as it is underthrusting beneath the northern Talesh, whereas the sedimentary cover deforms aseismically. The seismicity, depths, and previous focal mechanisms of the larger offshore events are consistent with low-angle underthrusting of the South Caspian floor. Within the Talesh, seismicity is mostly concentrated in the northern and southern structural arcs of the range, where deformation is more intense and complicated. Shallow crustal seismicity in the eastern flank of the Talesh is much less intense than in the western flank, where it signifies the deformation of the upper continental crust. One major observation is the lack of any significant N–S alignment of shallow epicentres inside the central Talesh to match the observed right-lateral shear deformation there. This suggests that shear deformation inside the Talesh may have a distributed nature, rather than being concentrated on a single thorough-going fault zone, as the Talesh moves northward relative to the South Caspian. We have determined a new moment tensor solution in the southwestern Talesh, with a dominant N–S trending right-lateral motion, the only solution so far confirming along-strike shear deformation in the Talesh

    Oxaliplatin disrupts nucleolar function through biophysical disintegration

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    Platinum (Pt) compounds such as oxaliplatin are among the most commonly prescribed anti-cancer drugs. Despite their considerable clinical impact, the molecular basis of platinum cytotoxicity and cancer specificity remain unclear. Here we show that oxaliplatin, a backbone for the treatment of colorectal cancer, causes liquid-liquid demixing of nucleoli at clinically relevant concentrations. Our data suggest that this biophysical defect leads to cell-cycle arrest, shutdown of Pol I-mediated transcription, and ultimately cell death. We propose that instead of targeting a single molecule, oxaliplatin preferentially partitions into nucleoli, where it modifies nucleolar RNA and proteins. This mechanism provides a general approach for drugging the increasing number of cellular processes linked to biomolecular condensates
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