Synthetic, Spectroscopic And Antibacterial Studies Of Fe(II),Co(II),Ni(II),Cu(II),and Zn(II)Mixed Ligand Complexes Of Nicotinamide And Cephalexin antibiotics

Mixed  ligand complexes of bivalent metal  ions, viz; M= Co(II), Ni(II), Cu(II) and Zn(II) of  the composition [M(Ceph)(NA)3]Cl  in 1:1:3  molar  ratio,  (where  Ceph = Cephalexin  and NA = Nicotinamide have  been  synthesized and  characterized  by  repeated  melting  point  determination, Solubility, Molar conductivity, determination  the percentage of  the metal  in  the  complexes  by  flame(AAS),  FT-IR, magnetic  susceptibility  measurements  and  electronic  spectral  data.  The   ligands and  their metal complexes were  screened  for  their antimicrobial activity against  six bacteria(gram +ve) and (gram -ve). Key words:(Cephalexin antibiotics,Nicotinamide ,mixed ligand) Complexes,Antibacterial activities, and spectral studie

Preparation , Characterization and Antimicrobial activities of {Fe(II),Co(II),Ni(II),Cu(II),and Zn(II)}Mixed Ligand Complexes Schiff base derived from Cephalexin drug and 4(dimethylamino)benzaldehyde with Nicotinamide

New Schiff base ligand (Z)-7-(2-(4-(dimethylamino)benzylideneamino)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid = (HL)was prepared via condensation of Cephalexin and 4(dimethylamino)benzaldehyde in methanol . Polydentate  mixed ligand  complexes were obtained from 1:1:2  molar ratio reactions with metal ions and HL, 2NA  on reaction with MCl2 .nH2O salt yields complexes corresponding to the formulas [M(L)(NA)2Cl] ,where M = Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and   NA=nicotinamide . The 1H-NMR, FT-IR, UV-Vis and elemental analysis were   used for the characterization of the ligand. The complexes were structurally studied through AAS, FT-IR, UV-Vis, chloride contents, conductance, and magnetic susceptibility measurements. All complexes are non-electrolytes in DMSO solution. Octahedral geometries have been suggested for each of the complexes. the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect ofthe bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff base has been screened against bacterial species., Staphylococcus aureus,Escherichia coil and the results are reported. Key words:(Cephalexin drug, Nicotinamide ,mixed ligand) Complexes, Antibacterial activities, and spectral studie

Preparation , Characterization and Antimicrobial activities of {Fe(II),Co(II),Ni(II),Cu(II),and Zn(II)}Mixed Ligand Complexes Schiff base derived from Cephalexin drug and 4(dimethylamino)benzaldehyde with Nicotinamide

Abstract New Schiff base ligand (Z)-7-(2-(4-(dimethylamino)benzylideneamino)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid = (HL)was prepared via condensation of Cephalexin and 4(dimethylamino)benzaldehyde in methanol . Polydentate mixed ligand complexes were obtained from 1:1:2 molar ratio reactions with metal ions and HL, 2NA on reaction with MCl 2 .nH 2 O salt yields complexes corresponding to the formulas [M(L)(NA) 2 Cl] ,where M = Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA=nicotinamide . The 1H-NMR, FT-IR, UV-Vis and elemental analysis were used for the characterization of the ligand. The complexes were structurally studied through AAS, FT-IR, UV-Vis, chloride contents, conductance, and magnetic susceptibility measurements. All complexes are non-electrolytes in DMSO solution. Octahedral geometries have been suggested for each of the complexes. the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect ofthe bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff base has been screened against bacterial species., Staphylococcus aureus,Escherichia coil and the results are reported