Numerical solution of a problem on bending oscillation of a rod

In article considered the problem of curved rod fluctuation with Jungs module. Shown the civility of the problem formulation. For solution used integro - interpolation method. Constructed implicit differential scheme, which realized by five - point sweep method. Conducted numerical calculations showed coincidence of theoretical calculation values of solution. Calculations conducted on the system of computer algebra Wolfram Mathematica. Results of calculations are given for two cases of fixing ends of the rod: both ends are fixed and one end is fixed other is free

DETERMINATION OF THE OPTIMAL DOSE AND EXPOSURE TIME FOR ENZYMATIC EXTRACTION OF PECTIN FROM MELONS

This article discusses the allocation of pectin from melons. In the study of technological modes (hydromodule, temperature) to obtain pectin-containing extract from melon pomace varieties «Torpedo», before the implementation of the enzyme preparation is carried out preliminary swelling of raw materials in water at a temperature of 48-500C for 12-15 hours. To work out the technological modes of obtaining pectin-containing extract from melon pomace varieties «Torpedo» by enzyme method, in the beginning worked out the optimal parameters: temperature and hydromodium to obtain pectin-containing extract

The order of morpheme acquisition in uzbek language (examples of chinese students who learning Uzbek as a second language)

The process of acquiring morphemes is one of the most interesting issues in psycholinguistics. Language acquisition is related to the first language and explains a certain order of acquisition of sounds, words, grammatical signs, sentence structure. This procedure serves as a basis for learning the language as a foreign language. The article shows how the hypothesis of natural order works in the Uzbek language, that is, an experiment was conducted on the acquisition of a certain morpheme earlier than other morphemes in the systematic acquisition of grammatical forms in the Uzbek language. It shows that an experiment was conducted with 14 Chinese language learners studying Uzbek as a foreign language. Experiments were conducted in China, in an environment where Uzbek is not the native language, and the results were generalized. The participants of the experiment were asked to put the necessary morpheme in the blank spaces and to translate the given sentences from Chinese to Uzbek, and to evaluate the experiment carried out by them. From the obtained result, the order of accuracy level of grammatical additions in Uzbek was determined and compared with the order of morphemes obtained in the acquisition of Uzbek as a first language

О НОВОЙ ТЕХНОЛОГИИ ПОДГОТОВКИ ГОРЯЧЕЙ ПИТЬЕВОЙ ВОДЫ

The present article contains information concerning the new Cl-anionization technology in the preparation of hot drinking water. In contrast with water softening, that replaces all the hardness salts by sodium cations in the cation exchanger, this new technology makes it possible to replace incrustating HCO3̄ and SO42--anions in a strong-base anion exchanger by Cl⁻-ions. As a result, the incrustation on the surfaces of heating hot water heaters is prevented. Thus, cations of hardness that are valuable for the human body remain in the water, the quality of the latter conforming to drinking water quality. Considering the important role of calcium and magnesium in the human body, in Germany and Turkey the minimum value of hardness cations in drinking water is limited to 2.85 and 7.50 mg-Eqv/l, respectively. According to the World Health Organization, in the composition of drinking water, the concentration of cations of magnesium and calcium is recommended, respectively, within 10–(20–30), and 20–50 mg/l; the minimum value of total hardness is 2–4 mg-Eqv/l. According to the developed technology drinking water is passed consistently in the downward direction through the mechanical and chlorineanionite exchanger filters. In the latter, the main part of HCO3̄ and SO42--water ions are exchanged for Cl-anions of anionite. Then the water is collected in the tank, from where it is pumped to the hot water heater through the ultraviolet disinfection unit. After the depletion of the anionite by HCO3̄ and SO42--anions, it is regenerated by a solution of 8–12 % NaCl. The results of research by the anion exchangers Purolite A200EMBCl and AB-17-8 are plotted. It is noted that when the specific consumption of salt for regeneration is of about 45–55 kg/m³, working exchange capacity of the A200EMBCl occurs to be in the range 300–370 g-Eqv/m³. For anionization of water, the residual concentration of HCO3̄-ions are changed from 0.5 to 3.2 mg-Eqv/l. The average concentration of these anions occurs to be between 1.8 and 2.2 mg-Eqv/l, when their initial value is 4.4 mg-Eqv/l.В статье приводятся сведения о новой технологии Cl-анионирования при подготовке горячей питьевой воды. Указанная технология в отличие от умягчения воды, где все соли жесткости замещаются в катионите катионами натрия, позволяет заменить накипеобразующие HCO-/3- и SO(2-)/4 -анионы в сильноосновном анионите Cl⁻-ионами. В результате предотвращается образование накипи на поверхностях нагрева подогревателей горячего водоснабжения. Таким образом, ценные для человеческого организма катионы жесткости остаются в составе воды, и ее качество удовлетворяет качеству питьевой воды. Учитывая важную роль кальция и магния для человеческого организма, в Германии и Турции ограничивается минимальное значение катионов жесткости в питьевой воде соответственно до 2,85 и 7,50 мг-экв/л. По данным Всемирной организации здравоохранения, в составе питьевой воды концентрация катионов магния и кальция рекомендуется соответственно в пределах 10–(20–30) и 20–50 мг/л; минимальное значение общей жесткости 2–4 мг-экв/л. Согласно разработанной технологии питьевая вода последовательно в направлении сверху вниз пропускается через механический и хлор-анионитный фильтры. В последнем основная часть HCO-/3- и SO(2-)/4-ионов воды обменивается на Cl-анионы анионита. Далее вода собирается в бак, откуда насосом через аппарат ультрафиолетовой дезинфекции подается в подогреватель горячего водоснабжения. После истощения анионита SO(2-)/4- и HCO-/3-анионами осуществляется его регенерация раствором (8–12)%-й NaCl. Излагаются результаты исследований анионитами Purolite A200EMBCl и АВ-17-8. Отмечается, что при удельном расходе соли на регенерацию около 45–55 кг/м³ рабочая обменная емкость A200EMBCl получается в пределах 300–370 г-экв/м³. При анионировании воды остаточная концентрация HCO-/3-ионов изменялась в пределах от 0,5 до 3,2 мг-экв/л. Средняя концентрация этих анионов при исходном их значении, равном 4,4 мг-экв/л, получилась в пределах от 1,8 до 2,2 мг-экв/л

Six-month therapy of CGRP monoclonal antibodies in real-world clinical practice: an interim analysis of efficacy and safety data

Introduction. Migraine is one of the most common disabling neurological disorders. Recently developed monoclonal antibodies to calcitonin gene-related peptide (CGRP) or its receptor are the first targeted medication for preventive therapy of both episodic and chronic migraine. They have been thoroughly investigated in clinical trials; however, there is little data from real-world clinical practice available to date. The aim of this study is to assess the efficacy and safety of 6 months of treatment with erenumab in real-world clinical practice and investigate the effect of the drug on the patients’ sensitivity to medicines for migraine headaches relief and patient satisfaction after treatment.Materials and methods. Our observational cohort prospective study included patients in our Headache Clinic prescribed monoclonal antibodies blocking the  CGRP-receptor  – erenumab. During the  investigation, we evaluated the  previous preventive therapy and its efficacy, the number of days with migraine per month, adverse events occurring during the erenumab treatment, depression and anxiety (HADS), migraine disability (MIDAS), the presence of allodynia (ACS-12) and improved response to acute therapy after treatment. A total of 42 patients participated in the study: 6 men, 36 women, the average age was 43.9 ± 12.2. Of them, 38 patients (90%) had chronic migraine. Thirty-two patients (76%) had previously been prescribed preventive therapy, which proved ineffective, and 10 patients (24%) had not once received any type of migraine prevention.Results. Among our patients, we identified 11 patients with resistant migraine and one patient with refractory migraine. During the study, two patients dropped out due to adverse events (constipation). Thirty patients continued the administration of erenumab 70 mg for at least six months. The average number of migraine days per month before treatment was 22.8, and after six months of treatment, it dropped to 7.3. Twenty-nine patients (72.5%) also noted that the response to acute headache treatment improved after the therapy.Conclusion. The results of our study are consistent with the international experience of using erenumab and confirm its effectiveness for migraine preventive therapy, including difficult-to-treat migraine cases. However, further studies with more participants and evaluation of predictors of successful monoclonal antibody therapy are still needed