Performance Evaluation of a Developed Maize Sheller

Assessing the performance characteristics of the developed maize shelling machine is the focus of this paper. Maize shelling machine was fabricated based on engineering design approach with the aid of software (CAD) and values, and was later fabricated at Afe Babalola University Ado Ekiti Central Workshop using suitable materials after considering the factors such as Hardness, ease of machining, tensile strength, availability, durability and the cost. The machine is electrically operated by an electric motor with power rating of 2.235 kW, speed of 1430 rpm and torque of 14.92 Nm. Kernel losses and damages were found to be very negligible. It shells 60 times as fast as hand shelling. The design presented in this paper is aided with computer software (Autodesk Inventor) to give the accurate and precise results. Maize shelling machine was developed to shell maize and separate the cob from the grains with appropriate engineering design factors. The efficiency of the machine is a benchmarked against the commercially available maize shelling machines. It has an average shelling capacity of 55 kg/hr, its shelling efficiency is 91.29 % and breakage is very insignificant, as well as losses. The machine can help to substantially reduce the human labor and stress involved in shelling maize and also reducing the time used for shelling operation on farms. There is no doubt that the machine will ease the long term problem of maize shelling especially for the rural farmers

Comprehensive characterization of the Published Kinase Inhibitor Set

Despite the success of protein kinase inhibitors as approved therapeutics, drug discovery has focused on a small subset of kinase targets. Here we provide a thorough characterization of the Published Kinase Inhibitor Set (PKIS), a set of 367 small-molecule ATP-competitive kinase inhibitors that was recently made freely available with the aim of expanding research in this field and as an experiment in open-source target validation. We screen the set in activity assays with 224 recombinant kinases and 24 G protein-coupled receptors and in cellular assays of cancer cell proliferation and angiogenesis. We identify chemical starting points for designing new chemical probes of orphan kinases and illustrate the utility of these leads by developing a selective inhibitor for the previously untargeted kinases LOK and SLK. Our cellular screens reveal compounds that modulate cancer cell growth and angiogenesis in vitro. These reagents and associated data illustrate an efficient way forward to increasing understanding of the historically untargeted kinome

Performance Evaluation of a Developed Maize Sheller

Assessing the performance characteristics of the developed maize shelling machine is the focus of this paper. Maize shelling machine was fabricated based on engineering design approach with the aid of software (CAD) and values, and was later fabricated at Afe Babalola University Ado Ekiti Central Workshop using suitable materials after considering the factors such as Hardness, ease of machining, tensile strength, availability, durability and the cost. The machine is electrically operated by an electric motor with power rating of 2.235 kW, speed of 1430 rpm and torque of 14.92 Nm. Kernel losses and damages were found to be very negligible. It shells 60 times as fast as hand shelling. The design presented in this paper is aided with computer software (Autodesk Inventor) to give the accurate and precise results. Maize shelling machine was developed to shell maize and separate the cob from the grains with appropriate engineering design factors. The efficiency of the machine is a benchmarked against the commercially available maize shelling machines. It has an average shelling capacity of 55 kg/hr, its shelling efficiency is 91.29 % and breakage is very insignificant, as well as losses. The machine can help to substantially reduce the human labor and stress involved in shelling maize and also reducing the time used for shelling operation on farms. There is no doubt that the machine will ease the long term problem of maize shelling especially for the rural farmers