Bayesian optimisation of hexagonal honeycomb metamaterial

Periodic mechanical metamaterials, such as hexagonal honeycombs, have traditionally been designed with uniform cell walls to simplify manufacturing and modelling. However, recent research has suggested that varying strut thickness within the lattice could improve its mechanical properties. To fully explore this design space, we developed a computational framework that leverages Bayesian optimisation to identify configurations with increased uniaxial effective elastic stiffness and plastic or buckling strength. The best topologies found, representative of relative densities with distinct failure modes, were additively manufactured and tested, resulting in a 54% increase in stiffness without compromising the buckling strength for slender architectures, and a 63% increase in elastic modulus and a 88% increase in plastic strength for higher volume fractions. Our results demonstrate the potential of Bayesian optimisation and solid material redistribution to enhance the performance of mechanical metamaterials

Nicotine Alters Limbic Function in Adolescent Rat by a 5-HT1A Receptor Mechanism

Epidemiological studies have shown that adolescent smoking is associated with health risk behaviors, including high-risk sexual activity and illicit drug use. Using rat as an animal model, we evaluated the behavioral and biochemical effects of a 4-day, low-dose nicotine pretreatment (60 μg/kg; intravenous) during adolescence and adulthood. Nicotine pretreatment significantly increased initial acquisition of cocaine self-administration, quinpirole-induced locomotor activity, and penile erection in adolescent rats, aged postnatal day (P)32. These effects were long lasting, remaining evident 10 days after the last nicotine treatment, and were observed when nicotine pretreatment was administered during early adolescence (P28–31), but not late adolescence (P38–41) or adulthood (P86–89). Neurochemical analyses of c-fos mRNA expression, and of monoamine transmitter and transporter levels, showed that forebrain limbic systems are continuing to develop during early adolescence, and that this maturation is critically altered by brief nicotine exposure. Nicotine selectively increased c-fos mRNA expression in the nucleus accumbens shell and basolateral amygdala in adolescent, but not adult animals, and altered serotonin markers in these regions as well as the prefrontal cortex. Nicotine enhancement of cocaine self-administration and quinpirole-induced locomotor activity was blocked by co-administration of WAY 100 635 (N-{2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide), a selective serotonin 1A (5-HT1A) receptor antagonist. Early adolescent pretreatment with the mixed autoreceptor/heteroceptor 5-HT1A receptor agonist, 8-OH-DPAT, but not the autoreceptor-selective agonist, S-15535, also enhanced quinpirole-induced locomotor activation. Nicotine enhancement of quinpirole-induced penile erection was not blocked by WAY 100 635 nor mimicked by 8-OH-DPAT. These findings indicate that early adolescent nicotine exposure uniquely alters limbic function by both 5-HT1A and non-5-HT1A receptor mechanisms