The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy

Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional vascularization and acquisition of epithelial-to-mesenchymal transition phenotype resulting in cell mobility and metastasis. Hypoxia alters cancer cell metabolism and contributes to therapy resistance by inducing cell quiescence. Hypoxia stimulates a complex cell signaling network in cancer cells, including the HIF, PI3K, MAPK, and NFĸB pathways, which interact with each other causing positive and negative feedback loops and enhancing or diminishing hypoxic effects. This review provides background knowledge on the role of tumor hypoxia and the role of the HIF cell signaling involved in tumor blood vessel formation, metastasis, and development of the resistance to therapy. Better understanding of the role of hypoxia in cancer progression will open new windows for the discovery of new therapeutics targeting hypoxic tumor cells and hypoxic microenvironment

Water management and reuse opportunities in a thermal power plant in Jordan

The Rehab power plant located in the Northern part of Jordan is presented as a case study of industrial water management. This power plant consumes boiler feed water in the amount of 200 m3/d of the freshground water available from nearby wells and it produces 193 m3/d of wastewater. Fifty seven water samples were taken from the different water treatment unit's effluents to evaluate the efficiency of these treatment units. Also, sixteen samples from the generated waste streams were taken and analyzed to characterize the wastewater of the different streams. It was found that the water treatment system provided water of much higher quality than needed for the boiler feed. The practice at the power plantwas to dispose of the generated wastewater into an evaporation pond that caused non compliance with environmental regulations and discarding of significant water reuse opportunities. It was found that 131 m3/d of the wastewater were of high quality and could be recycled inside the power plant after treatment by the existing water treatment system. Other reuse options were discussed and recommendations were provided for better operation of the water treatment systems and for reuse of the industrial water. The given scenarios will result in monetary savings and in aesthetical benefits

A robust uniform B-spline collocation method for solving the generalized PHI-four equation

In this paper, we develop a numerical solution based on cubic B-spline collocation method. By applying Von-Neumann stability analysis, the proposed technique is shown to be unconditionally stable. The accuracy of the presented method is demonstrated by a test problem. The numerical results are found to be in good agreement with the exact solution

Spotlight on ixazomib: Potential in the treatment of multiple myeloma

Despite the significant therapeutic advances achieved with proteasome inhibitors (PIs) such as bortezomib and carfilzomib in prolonging the survival of patients with multiple myeloma, the development of drug resistance, peripheral neuropathy, and pharmacokinetic limitations continue to pose major challenges when using these compounds. Ixazomib is a second-generation PI with improved activity over other PIs. Unlike bortezomib and carfilzomib, which are administered by injection, ixazomib is the first oral PI approved by US Food and Drug Administration. This review discusses the biochemical properties, mechanisms of action, preclinical efficacy, and clinical trial results leading to the US Food and Drug Administration approval of ixazomib

Integration v. Polarization Amongst Social Media Users: Perspectives through Social Capital Theory

There has been a growing debate about the extent to which social media has influenced the Arab World’s recent revolutions described as the “Arab Spring”. Despite difference in views concerning this issue, the role that social media played in enacting socio-political change is undeniable, a matter which attracted the interest of academia. Here, the power of social media in widening and strengthening relationships renovated and reinforced the concept of “social capital”, which could lead to integration or acculturation amongst affected societies. Underpinned by a social capital theory and the acculturation process, this commentary article adopts a critical approach and draws on historical events from the 2011 Egyptian revolution and beyond. We claim that, social media lead to social capital creation and integration when some fundamental associated factors exist namely: the bonding, bridging and linking factors. Social media adoption lead to political integration when these factors existed during the Egyptian revolution and lead to polarisation when there was no contextual triggering factor before the revolution and no access to resources after the revolution. We provide some insightful perspectives on the role of social media in social-political change

Optimizing the Flexural Behavior of Bamboo Reinforced Concrete Beams Containing Cassava Peel Ash using Response Surface Methodology

The growing concern to reduce global warming has necessitated the use of more eco-friendly materials in construction. The study is focused on the utilization of cassava peel ash as supplementary cementitious material and bamboo as reinforcement in concrete beams. The response surface methodology approach was explored to determine the effect of simultaneously varying the cassava peel ash content, bamboo size, beam length, and beam depth on the flexural strength and strain of beams. An analysis of variance was carried out on experimentally obtained results to determine the accuracy of the obtained models and the contributions made by the linear interaction and quadratic terms on flexural strength and flexural strain. The coefficient of determination obtained for RSM models showed a good correlation between all predicted and experimentally obtained results. The optimum conditions obtained for bamboo-reinforced concrete containing cassava peel ash were 3% cassava peel ash, 16 mm bamboo diameter, 500 mm beam length, and 150 mm beam depth. The predicted flexural strengths were 11.85, 14.34, and 14.95 N/mm2 and flexural strains of 0.64, 0.67, and 0.91 for 28 days, 56 days, and 90 days, respectively. To validate the model prediction, a laboratory experiment was conducted using the optimum mix design proportion. From the results obtained, it was observed that the experimental results were close to those predicted by the models. These models can be efficiently used for simulating the flexural behavior of bamboo-reinforced concrete beams. Doi: 10.28991/CEJ-2023-09-08-011 Full Text: PD

Liposomal phytohemagglutinin: In vivo T-cell activator as a novel pan-cancer immunotherapy

Immunotherapy is an attractive approach for treating cancer. T-cell engagers (TCEs) are a type of immunotherapy that are highly efficacious; however, they are challenged by weak T-cell activation and short persistence. Therefore, alternative solutions to induce greater activation and persistence of T cells during TCE immunotherapy is needed. Methods to activate T cells include the use of lectins, such as phytohemagglutinin (PHA). PHA has not been used to activate T cells in vivo, for immunotherapy, due to its biological instability and toxicity. An approach to overcome the limitations of PHA while also preserving its function is needed. In this study, we report a liposomal PHA which increased PHA stability, reduced toxicity and performed as an immunotherapeutic that is able to activate T cells for the use in future cancer immunotherapies to circumvent current obstacles in immunosuppression and T-cell exhaustion