2 research outputs found
ABNORMALNI TEST OPTEREĆENJA GLUKOZOM I BLAGI GESTACIJSKI DIJABETES
Get PDFObjective. The status of carbohydrate metabolism of pregnant women with positive glucose challenge test (GCT), but normal oral glucose tolerance test (OGTT) and their neonates are not defined clearly. Study Design. Pregnant women with normal GCT (n: 120), with abnormal glucose challenge test (AGCT) but normal OGTT (n: 67) and with gestational diabetes (GDM, n: 67) were included into the study. Insulin sensitivity was evaluated by fasting insulin level, homeostasis model assessment of insulin resistance index (HOMA-IR); quantitative insulin check index (QUICKI) and ISOGTT. Serum insulin and glucose values during OGTT were documented. Perinatal outcome and delivery modalities were compared. Results. Both GDM (31.6±5.9 yrs) and AGCT groups (29.0±4.0 yrs) were older than controls (28.1±4.9 yrs). Body mass index (BMI) was the predominant factor affecting both AGCT and GDM groups (OR: 3.78 and 5.97 respectively). Despite there was no significance between insulin indices; serum glucose and insulin values were similarly different; macrosomic infant and caesarean section rates were higher than controls in both GDM and AGCT groups in favor of gestational diabetics (6.6% vs. 18.9%; p=0.0001 and 20% vs. 27.7% p=0.0001 respectively). Conclusion. Pregnant woman with abnormal glucose challenge test have impaired carbohydrate metabolism as in gestational diabetics with a lesser severe degree.Cilj istraživanja. Stanje metabolizma ugljikohidrata u trudnica s pozitivnim testom probira (glucose challenge test – GCT), a normalnim testom opterećenja glukozom (OGTT) te njihove novorođenčadi, nije jasno definirano. Način istraživanja. U studiju su uključene trudnice s normalnim GCT-om (n: 120), s abnormalnim GCT-om ali normalnim OGTT-om (n:67 te trudnice s gestacijskim dijabetesom (n: 67). Insulinska osjetljivost je vrednovana jutarnjiom vrijednošću insulina, modelom prosudbe homeostaze indeksom rezistencije na inzulin (HOMA-IR), kvantitativnim indeksom provjere insulina (QUICKI) i ISOGTT-om. Vrijednosti serumske glukoze i inzulina su analizirane. Uspoređen je perinatalni ishod i način poroda. Rezultati. Trudnice s GDM (31,6±5,9 godina) i one s AGCT (29,0±4,0 godina) su bile starije dobi od kontrolnih trudnica (28,1±4,9 godina). Indeks tjelesne težine (BMI) je bio presudni čimbenik u skupini s AGCT i GDM (OR: 3,78 odnosno 5,97). Unatoč tome nije bilo značajnosti među inzuilinskim indeksima; serumske vrijednosti glukoze i inzulina su bile slično različite; makrosomna djeca i stopa carskih rezova su u trudnica s AGCT i OGTT bile češće, posebice u trudnica s GDM (6,6% prama 18,9%, p = 0,0001; 20% prama 27,7%, p = 0,0001). Zaključak. Trudnice s abnormalnim testom probira na glukozu (AGCT) imaju poremećaj metabolizma ugljikohidrata kao i trudnice s gestacijskim dijabetesom (GDM), ali u nešto manjoj mjeri
ABNORMALNI TEST OPTEREĆENJA GLUKOZOM I BLAGI GESTACIJSKI DIJABETES
Get PDFObjective. The status of carbohydrate metabolism of pregnant women with positive glucose challenge test (GCT), but normal oral glucose tolerance test (OGTT) and their neonates are not defined clearly. Study Design. Pregnant women with normal GCT (n: 120), with abnormal glucose challenge test (AGCT) but normal OGTT (n: 67) and with gestational diabetes (GDM, n: 67) were included into the study. Insulin sensitivity was evaluated by fasting insulin level, homeostasis model assessment of insulin resistance index (HOMA-IR); quantitative insulin check index (QUICKI) and ISOGTT. Serum insulin and glucose values during OGTT were documented. Perinatal outcome and delivery modalities were compared. Results. Both GDM (31.6±5.9 yrs) and AGCT groups (29.0±4.0 yrs) were older than controls (28.1±4.9 yrs). Body mass index (BMI) was the predominant factor affecting both AGCT and GDM groups (OR: 3.78 and 5.97 respectively). Despite there was no significance between insulin indices; serum glucose and insulin values were similarly different; macrosomic infant and caesarean section rates were higher than controls in both GDM and AGCT groups in favor of gestational diabetics (6.6% vs. 18.9%; p=0.0001 and 20% vs. 27.7% p=0.0001 respectively). Conclusion. Pregnant woman with abnormal glucose challenge test have impaired carbohydrate metabolism as in gestational diabetics with a lesser severe degree.Cilj istraživanja. Stanje metabolizma ugljikohidrata u trudnica s pozitivnim testom probira (glucose challenge test – GCT), a normalnim testom opterećenja glukozom (OGTT) te njihove novorođenčadi, nije jasno definirano. Način istraživanja. U studiju su uključene trudnice s normalnim GCT-om (n: 120), s abnormalnim GCT-om ali normalnim OGTT-om (n:67 te trudnice s gestacijskim dijabetesom (n: 67). Insulinska osjetljivost je vrednovana jutarnjiom vrijednošću insulina, modelom prosudbe homeostaze indeksom rezistencije na inzulin (HOMA-IR), kvantitativnim indeksom provjere insulina (QUICKI) i ISOGTT-om. Vrijednosti serumske glukoze i inzulina su analizirane. Uspoređen je perinatalni ishod i način poroda. Rezultati. Trudnice s GDM (31,6±5,9 godina) i one s AGCT (29,0±4,0 godina) su bile starije dobi od kontrolnih trudnica (28,1±4,9 godina). Indeks tjelesne težine (BMI) je bio presudni čimbenik u skupini s AGCT i GDM (OR: 3,78 odnosno 5,97). Unatoč tome nije bilo značajnosti među inzuilinskim indeksima; serumske vrijednosti glukoze i inzulina su bile slično različite; makrosomna djeca i stopa carskih rezova su u trudnica s AGCT i OGTT bile češće, posebice u trudnica s GDM (6,6% prama 18,9%, p = 0,0001; 20% prama 27,7%, p = 0,0001). Zaključak. Trudnice s abnormalnim testom probira na glukozu (AGCT) imaju poremećaj metabolizma ugljikohidrata kao i trudnice s gestacijskim dijabetesom (GDM), ali u nešto manjoj mjeri
