Öğretmen Etkileşim Ölçeği (Öeö) ve Çocuk-Öğretmen Etkileşim Ölçeği (Çöeö) Geçerlik ve Güvenirlik Çalışmaları

DergiPark: 754702tredOkul öncesi eğitimin niteliği tüm dünyada yaygın olarak 1970’lerden beri araştırılmaktadır. Okul öncesi eğitiminin kalitesinin artırılmasında şüphesiz ki öğretmen en etkili unsurlardan biridir. Öğretmenin okul öncesi dönem çocuğuyla aralarındaki etkileşim çocuğun yaşamında hayati öneme sahiptir. Nitelikli bir okul öncesi eğitiminde çocukların öğretmen ile etkileşimleri onların zihinsel kapasitelerini artırmakta, sosyal becerilerinin gelişimini desteklemekte ve toplumdaki ahlak kurallarına uygun davranışlar göstermelerini sağlamaktadır. Bunun yanında kaliteli öğrenci-öğretmen etkileşimi çocuğun akademik yaşantısına katkı sağlarken bir yandan da çocuğun daha katılımcı, girişken ve uyumlu olmasına ve akademik gelişimini tamamlamasına katkıda bulunmaktadır. Öğretmen-öğrenci etkileşiminin, çocuğun gelişimi üzerinde önemli etkiye sahip olması, öğretmen-çocuk arasındaki etkileşimin niteliğinin ölçülmesi için geçerli ve güvenilir bir ölçme aracı ihtiyacını doğurmaktadır. Bu çalışmanın amacı “Öğretmen Etkileşim Ölçeği- ÖEÖ” (Caregiver Interaction Scale-CIS; Arnett, 1989) ve “Çocuk Öğretmen Etkileşim Ölçeği- ÇÖEÖ” (Child Caregiver Interaction Scale-CCIS; Carl, 2010) ölçme araçlarının geçerlik ve güvenirlik çalışmalarını ve Türkçe adaptasyonlarını yapmaktır. Çalışmaya Edirne’de okulöncesi eğitim kurumlarındaki çalışma grubu olarak 41 öğretmen ve 147 çocuk dâhil edilmiştir. İlişkisel tarama modeli olarak tasarlanmış olan bu çalışmada çalışma grubunu oluşturan öğretmenler ve çocuklar arasındaki ilişkiler araştırmacılar tarafından gözlenmiştir. Çalışmada ulaşılan verilerin analizi doğrulayıcı faktör analizi ile test edilmiştir. Ölçeklerin geçerli ve güvenilir olduğuna yönelik sonuçlar, çalışmanın bulgular ve sonuç kısmında açıklanmıştır

An assessment of nasal and orbital parameters in human fetuses

Background: Nasal bone aplasia and hypoplasia have been reported on fetuses with aneuploidy. Trisomy 21 is one of the most common chromosomal abnormality detected in new-borns. The purpose of our study is to obtain data of some face parameters in Turkish fetal population and to contribute creation of reference ranges that may be used for prenatal diagnosis.Methods: This study was performed in 66 spontaneously aborted fetuses (47 second trimester and 19 third trimester) (28 male and 38 female) with no detectable external pathology or anomalies. Measurements were designed as nasal bone length (NBL), nose length (NL), nose width (NW), nostril width (NsW),                intraocular distance (IOD), innercanthal distance (ICD), outercanthal distance (OCD), orbital diameter (OD), biparietal diameter (BPD).Results: In comparison between genders, ICD and BPD averages were found significantly higher in male fetuses than female fetuses (P<0.05). There was not any statistically significant difference between averages of the values on the right and left. The difference between second and the third trimester was significant in terms of all parameters (P<0.05). A strong correlation was detected between gestational age and our parameters.Conclusions: Present study has contributed to create reference ranges of Turkish community. When importance of early diagnosis is considered, we believe that this data will be useful for clinicians

Diagnosis of comorbid migraine without aura in patients with idiopathic/genetic epilepsy based on the gray zone approach to the International Classification of Headache Disorders 3 criteria

BackgroundMigraine without aura (MwoA) is a very frequent and remarkable comorbidity in patients with idiopathic/genetic epilepsy (I/GE). Frequently in clinical practice, diagnosis of MwoA may be challenging despite the guidance of current diagnostic criteria of the International Classification of Headache Disorders 3 (ICHD-3). In this study, we aimed to disclose the diagnostic gaps in the diagnosis of comorbid MwoA, using a zone concept, in patients with I/GEs with headaches who were diagnosed by an experienced headache expert.MethodsIn this multicenter study including 809 consecutive patients with a diagnosis of I/GE with or without headache, 163 patients who were diagnosed by an experienced headache expert as having a comorbid MwoA were reevaluated. Eligible patients were divided into three subgroups, namely, full diagnosis, zone I, and zone II according to their status of fulfilling the ICHD-3 criteria. A Classification and Regression Tree (CART) analysis was performed to bring out the meaningful predictors when evaluating patients with I/GEs for MwoA comorbidity, using the variables that were significant in the univariate analysis.ResultsLonger headache duration (&lt;4 h) followed by throbbing pain, higher visual analog scale (VAS) scores, increase of pain by physical activity, nausea/vomiting, and photophobia and/or phonophobia are the main distinguishing clinical characteristics of comorbid MwoA in patients with I/GE, for being classified in the full diagnosis group. Despite being not a part of the main ICHD-3 criteria, the presence of associated symptoms mainly osmophobia and also vertigo/dizziness had the distinguishing capability of being classified into zone subgroups. The most common epilepsy syndromes fulfilling full diagnosis criteria (n = 62) in the CART analysis were 48.39% Juvenile myoclonic epilepsy followed by 25.81% epilepsy with generalized tonic-clonic seizures alone.ConclusionLonger headache duration, throbbing pain, increase of pain by physical activity, photophobia and/or phonophobia, presence of vertigo/dizziness, osmophobia, and higher VAS scores are the main supportive associated factors when applying the ICHD-3 criteria for the comorbid MwoA diagnosis in patients with I/GEs. Evaluating these characteristics could be helpful to close the diagnostic gaps in everyday clinical practice and fasten the diagnostic process of comorbid MwoA in patients with I/GEs

The Known Genetic Defects in Common Variable İmmunodeficiency

Yaygın değişken immünyetmezlik (YDİY), immünyetmezlik hastalıklarının nispeten sık görülen bir şekli olup, immünglobulin üretiminde eksiklik ve primer antikor yetmezliği ile giden heterojen bir hastalık grubudur. Son yıllarda, tanımlanan çeşitli monogenik defektlerin YDİY'in klinik ve laboratuvar bulgularındaki değişkenliği belirlediği ve immünopatogenezinde rol oynadığı anlaşılmıştır. Bu derlemede, YDİY ile ilişkili olan ICOS (inducible co-stimulator), TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor), CD19, MSH5 (MutS Homologue 5 Mutations), BAFF-R (B cell activating factor receptor), CD20, CD81, CD21, LRBA (lipopolysaccharide-responsive beige-like anchor) molekül defektleri ve bunların genetik temellerinin gözden geçirilmesi amaçlanmıştır.Common variable immunodeficiency (CVID) is a relatively common form of immunodeficiency disorders which constitutes a mixed group of heterogeneous conditions linked by lack of immune globulin production and primary antibody failure. Recently, it is understood that various monogenic defects determine the variability in phenotype and have roles in the immunopathogenesis of CVID. In this review, the molecular defects related to CVID which are ICOS (inducible co-stimulator), TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor), CD19, MSH5 (MutS Homologue 5 Mutations), BAFF-R (B cell activating factor receptor), CD20, CD81, CD21, LRBA (lipopolysaccharide-responsive beige-like anchor), and their genetic basis were aimed to be reviewed

Translocation t(12;22)(p13;q11) in a patient with AML M1

WOS: 000411861000170

Translocation t(6;9)(p22;q34) in a patient with acute myeloblastic leukemia

WOS: 000411861000169

Management of Amniocentesis in High Risk Pregnancies and The Evaluation of the Results

OBJECTIVE: To evaluate amniocentesis results applied to high risk pregnancies in our clinic. STUDY DESIGN: In this study, we have perf ormed amniocentesis in 16th-24th weeks of 447 pregnancies who had previous history of chromosomally abnormal fetus, high risk in triple test screening, in which abnomal fetus was seen in ultrasonography, high maternal anxiety, and maternal age 35 years old and above. Cytogenetic analyses were applied to all specimens. RESULTS: Appropriate amount of amniotic fluid was obtained by 98.65%, the successful culture rate was 97.31%, cardocentesis was applied to only one case of 12 cases in which no prolif eration was detected in culture The cordocentesis result was 47XX+18. According to cytogenetic evaluation results, chromosomal abnormality was detected in 29 cases (6.65%). In 7 patients Trisomy 21, in 3 cases Trisomy 18, in one case Trisomy 13, in 3 cases triploidy (69,XXX), in one case mosaicism (46XY/47XYY), in 5 cases translocation, in 9 cases inversion type chromosomal abnormality was detected. After 447 amniocentesis, 5 (1.11%) fetal losses developed. In 2 cases the leakage of amniotic fluid, in one case premature rupture of membranes, in one case cramps and vaginal bleeding and in only one case spontaneous abortus was detected. When the maternal educational level of the cases were evaluated, it was f ound that about one half of the cases had high level education. CONCLUSIONS: If amniocentesis is carried out by highly skilled physicians and if optimal culture conditions are available, amniocentesis is avaluable invasive prenatal diagnosis method with high accuracy and safety, with minimal complications

Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells

coskun, zeynep mine/0000-0003-4791-6537WOS: 000513379500001PubMed: 32061154Propolis is a natural resinous substance obtained from beehives, and emerging evidence supports that it has antitumor, antiinflammatory, antioxidant, and antimicrobial activities. the aim of the study is to examine the cytotoxic, antioxidant, and apoptotic features of ethanolic propolis extract (PE) on C6 glioma cells. the cells were treated with ethanolic PE at various concentrations for 24 hours, after which the total antioxidant status (TAS) and total oxidant status; malondialdehyde, protein carbonyl, 8-hydroxy-2 '-deoxyguanosine, and glutathione (GSH) levels; Cu/Zn-superoxide dismutase (Cu/Zn-SOD) activity; and apoptotic markers were measured. Ethanolic PE at 100, 250, and 500 mu g/mL concentrations showed optimal activity on C6 glioma cells. TAS and GSH levels were significantly increased in C6 glioma cells treated with 100 and 500 mu g/mL PE compared to control cells (P < .05). Similarly, the activity of Cu/Zn-SOD was higher in C6 glioma cells treated with 250 or 500 mu g/mL ethanolic PE compared to control cells (P < .05), as was the caspase-3 mRNA expression level. the highest levels of caspase-8 and -9 expression were in C6 glioma cells treated with 500 mu g/mL PE. Collectively, our results indicate that ethanolic PE has cytotoxic and apoptotic effects on C6 glioma cells. Furthermore, it may provide a protective role in the antioxidant defense system. PE shows potential for development as a natural antioxidant and apoptotic agent for the treatment of brain tumors