Is There Any Correlation Between De Ritis Ratio and Prostate Cancer in Males Who Underwent Transrectal Prostate Biopsy?

Objective:This study aims to evaluate the diagnostic value of the De Ritis ratio (DRR) in predicting prostate cancer (PCa) and clinically significant prostate cancer (csPCa) in biopsy-naive patients with suspected PCa.Method:We retrospectively reviewed medical records of 282 male patients who underwent transrectal ultrasound-guided prostate needle biopsy (PNB) between January 2015 and July 2019. Demographic and clinical characteristics of the patients including digital rectal examination findings, preoperative prostate-specific antigene (PSA), aspartate aminotransferase levels, alanine aminotransferase levels, prostate volume, comorbidities and pathological findings of the PNB specimens were noted in detail for each patient. The study cohort was divided into two groups according to the histopathological results of PNB specimens (group 1: patients with benign histopathology, group 2: patients with PCa). The receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic performance of PSA, PSA density and DRR in predicting PCa.Results:The median age of the participants was 64 (59-69) years. While 71.6% (n=202) of the participants were in group 1, 28.4% (n=80) of them were in group 2. The median DRR value of group 1 was 1.08 (range: 0.89-1.32), and the median DRR value of group 2 was determined as 1.19 (range: 0.95-1.56), and the median DRR value of group 2 was found to be statistically significantly higher than that of group 1 (p=0.013). Statistically significant but a weak positive correlation was observed between PCa in PNB specimens and DRR (r=0.149, p=0.012), while there was no statistically significant correlation between csPCa in PNB specimens and DRR (r=0.002, p=0.983). The ROC curve analysis showed that the cut-off value of DRR for the presence of PCa in PNB specimens was 1.125 and the area under curve was 0.595 (95% confidence interval=0.518-0.672, p=0.013) for the presence of PCa in PNB specimens.Conclusion:This study suggests that DRR had restricted diagnostic importance in predicting PCa in biopsy-naive patients who underwent transrectal PNB

Citation Analysis of the Articles Published in the Bagcilar Medical Bulletin Between December 2016 and June 2020

Objective:To describe publication characteristic and citation analysis of Bagcilar Medical Bulletin (BMB) since its first publication time to January 2020 using bibliometric methods.Method:Researched articles published in the BMB between December 2016 and June 2020 have been analyzed. The journal database was evaluated according to study type (original research, review, case report, letter to the editor), related scientific subspecialty and the geographical origin. We also calculated the rates of citation by dividing the total number of citations received by all papers by the total number of papers.Results:A total of 88 articles were included in the study. The articles about neurosurgery, anesthesia and pediatrics were in the top three (27.27%, 13.63% and 11.36%, respectively). Citation rates of the original article, case report and review were 15.7%, 10.3% and 0%, respectively. Most of the articles (81.81%) were published from Marmara Region in Turkey. Of the articles, 4 (4.5%) were international papers submitted from 2 different countries. All international papers were preclinical subspecialties like pharmacology, microbiology and physiology.Conclusion:Our study provides an opportunity to compare the citation numbers and characteristics before and after indexing of the journal in TUBITAK/ULAKBIM, in near future

The anxiolytic effects of testosterone may be modulated by central nervous system androgen receptor activity in gonadectomized male mice

WOS: 000424033100273

Effect of Ge layer thickness on the formation of Mn5Ge3 thin film on Ge/Si (1 1 1)

The effect of Ge buffer layer thickness on the formation of epitaxial Mn5Ge3films and their magnetic properties has been investigated. Epitaxial ferromagneticMn5Ge3thin films were deposited on Ge/Si (1 1 1) substrates using solid phase epitaxy. The crystalline quality, chemical composition and magnetic properties of thefilms were investigated by x-ray diffraction, transmission electron microscopy, x-ray photoelectron spectroscopy, electron spin resonance. Increasing the thickness ofthe Ge layer significantly enhanced the crystallinity and magnetic homogeneity of Mn5Ge3films. Both structural and magnetic investigations show substantialdiffusion of Mn atoms through Ge buffer layer which results in the formation of Mn5Si3and a delay in Mn5Ge3formation until the thickness of the Ge layer reaches to70 nm. The observed magnetic behavior for the films grown on different Ge thicknesses is interpreted in terms of changes in the magnetic phases and surfaceproperties. These results show that Mn5Ge3can be epitaxially grown on Si substrate with Ge buffer layer thicknesses of above 140 nm, despite ∼ 8% lattice mismatchbetween Mn5Ge3and Si (1 1 1