Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resource-limited setting of southwest ethiopia

<p>Abstract</p> <p>Background</p> <p>Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower the risk that drug resistance will develop, and reduce morbidity and mortality. Little is known about the rate and predictors of adherence in Ethiopia. Therefore this study determines the magnitude and predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in Southwest Ethiopia.</p> <p>Methods</p> <p>A cross sectional study was carried out from January 1, 2009 to March 3, 2009 among 319 adult PLWHA (≥ 18 years) attending ART clinic at Jimma university Specialized Hospital (JUSH). Multiple Logistic regression models were constructed with adherence and independent variables to identify the predictors.</p> <p>Results</p> <p>About 303(95%) of the study subjects were adherent based on self report of missed doses (dose adherence) in a one-week recall before the actual interview. The rate of self reported adherence in the study based on the combined indicator of the dose, time and food adherence measurement was 72.4%. Patients who got family support were 2 times [2.12(1.25-3.59)] more likely to adhere than those who didn't get family support as an independent predictor of overall adherence (dose, time and food). The reasons given for missing drugs were 9(27.3%) running out of medication/drug, 7(21.2%) being away from home and 7(21.2%) being busy with other things.</p> <p>Conclusion</p> <p>The adherence rate found in this study is similar to other resource limited setting and higher than the developed country. This study highlights emphasis should be given for income generating activities and social supports that helps to remember the patients for medication taking and management of opportunistic infections during the course of treatment.</p

Knowledge and attitudes of caregivers of HIV-infected children toward antiretroviral treatment in Ethiopia.

OBJECTIVE: To determine the knowledge and attitude of caregivers of HIV-infected children taking antiretroviral therapy (ART) in Ethiopia. METHODS: A total of 390 caregivers of HIV infected children were surveyed in selected ART units in Addis Ababa. Data was collected using a pretested and structured questionnaire. RESULTS: Seventy two (18.5%) of the caregivers believed that HIV can be cured by taking antiretroviral (ARV) medications. Three hundred and nineteen (81.8%) participants reported that taking ARVs incorrectly would bring about resistance to the drug. Three hundred and eighty (97.4%) caregivers had favorable attitude toward administration of ARV medication to children. Almost all of the caregivers (379, 97.2%) reported to have had enough privacy in their consultation with the doctor or nurse. Having enough privacy during consultation (OR 7.18; 95% CI 1.24-41.6) and knowledge that HIV cannot be cured by ART (OR 3.89; 95% CI 1.05-14.4) were associated with favorable attitude toward ART administration. CONCLUSION: The majority of the caregivers had good knowledge and favorable attitude toward administration of ARV medication to children. However some misconceptions such as beliefs that ART cures HIV/AIDS exist. PRACTICAL IMPLICATIONS: Health education efforts should continue focusing on the objective of ART treatment and toward dispelling the prevailing misconceptions

Food insecurity and associated factors among HIV-infected individuals receiving highly active antiretroviral therapy in Jimma zone Southwest Ethiopia

Abstract Background In resource limited settings, many People Living with HIV/AIDS (PLWHA) lack access to sufficient quantities of nutritious foods, which poses additional challenges to the success of antiretroviral therapy (ART). Maintaining adequate food consumption and nutrient intake levels and meeting the special nutritional needs to cope up with the disease and the ART are critical for PLWHA to achieve the full benefit of such a treatment. Objective To determine the prevalence and correlates of food insecurity among HIV-infected individuals receiving highly active antiretroviral therapy in resource-limited settings. Methods A cross sectional study was carried out from January 1, 2009 to March 3, 2009 at ART clinic at Jimma University specialized hospital (JUSH) in Ethiopia. We used multivariable logistic regression model to compare independent risk factors by food insecurity status among 319 adult PLWHA (≥18 years) attending ART Clinic. Results A total of 319 adult PLWHA participated in the study giving a response rate of 100%. Out of 319 PLWHA the largest numbers of participants, 46.4% were in the age group of 25-34 years. The overall 201(63.0%) PLWHA were food insecure. Educational status of elementary or lower [OR = 3.10 (95%CI; (1.68-5.71)], average family monthly income Conclusion Food insecurity is a significant problem among PLWHA on HAART. Lower educational status and low family income were the predictors of food insecurity. Food security interventions should be an integral component of HIV/AIDS care and support programs. Special attention need to be given to patients who have lower educational status and are members of households with low income.</p